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Hypoxia-Inducible Factor-1 Alpha in the Heart
Cardiology in Review, 2012Hypoxia-inducible factor (HIF) is a set of transcription factors that regulate the cellular response to hypoxia. There is a great body of evidence supporting the protective role of HIF-1α in cardiovascular pathophysiology, however, newer studies are hinting at a maladaptive and deleterious role of this transcription factor that merits further ...
Satwat, Hashmi, Suhail, Al-Salam
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Cancer Therapy By Targeting Hypoxia-Inducible Factor-1
Current Cancer Drug Targets, 2010Tumors are invariably less well-oxygenated than the normal tissues from which they arose. Hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator, plays a central role in the adaptation of tumor cells to hypoxia by activating the transcription of genes, which regulate several biological processes including angiogenesis, cell proliferation ...
Y, Li, D, Ye
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Honokiol inhibits hypoxia-inducible factor-1 pathway
International Journal of Radiation Biology, 2011Hypoxia-inducible factor-1α (HIF-1α) plays a pivotal role in the reaction of a tumour to hypoxia. In this study, we examined the inhibitory effect of a natural compound, honokiol, on HIF-1α activity and tumour growth in combination with radiation.The inhibitory effect of honokiol on hypoxia-responsive element (HRE) controlled luciferase activity and ...
Keng-Li, Lan +8 more
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Oxygen(es) and the hypoxia-inducible factor-1.
Biological chemistry, 1997The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) heterodimeric transcription factor activated by reductions in oxygen concentration (hypoxia). Activated HIF-1 upregulates expression of genes involved in the adaptation of higher organisms to hypoxic conditions, caused by e.g.
Wenger, R H, Gassmann, M
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Involvement of Hypoxia-Inducible Factor 1 in Pulmonary Pathophysiology
Chest, 2005Hypoxia-inducible factor (HIF)-1 is a transcription factor that is activated in response to hypoxia and growth factor/cytokine signaling via regulation of the HIF-1alpha subunit. HIF-1 has been implicated in the pathogenesis of pulmonary hypertension based on both experimental and clinical data.
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Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Science's STKE, 2007Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan organisms and is composed of HIF-1α and HIF-1β subunits. Under hypoxic conditions, HIF-1 regulates the transcription of hundreds of genes in a cell type–specific manner. The HIF-1α subunit is regulated by O
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Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia
Endocrine Reviews, 2023Rodrigo A Toledo +2 more
exaly
Hypoxia and hypoxia-inducible factors in diabetes and its complications
Diabetologia, 2021Sergiu-Bogdan Catrina +2 more
exaly