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Hypoxia-Inducible Factor-1 (HIF-1)
Molecular Pharmacology, 2006Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. The primary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive transcriptional ...
Qingdong, Ke, Max, Costa
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Regulation of angiogenesis by hypoxia-inducible factor 1
Critical Reviews in Oncology/Hematology, 2006Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression.
Kiichi, Hirota, Gregg L, Semenza
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Hypoxia-inducible factor 1 in autoimmune diseases
Cellular Immunology, 2016Autoimmune disorders are a complicated and varied group of diseases arising from inappropriate immune responses. Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which ...
Wei, Deng +4 more
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Hypoxia‐inducible factor‐1 and oncogenic signalling
BioEssays, 2004AbstractAn understanding of underlying mechanisms involved in the activation of HIF‐1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human cancer. Changes in microenvironmental stimuli such as hypoxia and growth factors in combination with genetic lesions, such as ...
Bardos, JI, Athcroft, M
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Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective
Current Hypertension Reports, 2022Preeclampsia (PE) is a serious and distinct type of pregnancy-induced hypertension, with an incidence of 2-8% worldwide. PE is defined as pregnancy-related hypertension with proteinuria and peripheral edema after 20 weeks of gestation. Hypoxic placenta triggers the release of inflammatory and humoral substances into maternal circulation, leading to ...
Albogami, Sarah +10 more
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Hypoxia‐Inducible Factor 1 Inhibitors
2007The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
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Signal transduction to hypoxia-inducible factor 1
Biochemical Pharmacology, 2002Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. HIF-1 activity is regulated by the cellular O2 concentration and by the major growth factor-stimulated signal ...
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Cancer Therapy By Targeting Hypoxia-Inducible Factor-1
Current Cancer Drug Targets, 2010Tumors are invariably less well-oxygenated than the normal tissues from which they arose. Hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator, plays a central role in the adaptation of tumor cells to hypoxia by activating the transcription of genes, which regulate several biological processes including angiogenesis, cell proliferation ...
Y, Li, D, Ye
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Honokiol inhibits hypoxia-inducible factor-1 pathway
International Journal of Radiation Biology, 2011Hypoxia-inducible factor-1α (HIF-1α) plays a pivotal role in the reaction of a tumour to hypoxia. In this study, we examined the inhibitory effect of a natural compound, honokiol, on HIF-1α activity and tumour growth in combination with radiation.The inhibitory effect of honokiol on hypoxia-responsive element (HRE) controlled luciferase activity and ...
Keng-Li, Lan +8 more
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Regulation of Vascularization by Hypoxia‐Inducible Factor 1
Annals of the New York Academy of Sciences, 2009Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia that are mediated by hypoxia‐inducible factor 1 (HIF‐1). In patients with peripheral arterial disease, these responses are impaired by aging and diabetes, leading to critical limb ischemia and amputation.
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