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Dexamethasone impairs hypoxia-inducible factor-1 function
Biochemical and Biophysical Research Communications, 2008Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription-factor composed of alpha- and beta-subunits. HIF-1 is not only necessary for the cellular adaptation to hypoxia, but it is also involved in inflammatory processes and wound healing. Glucocorticoids (GC) are therapeutically used to suppress inflammatory responses.
A E, Wagner +4 more
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Hypoxia-Inducible Factor 1 in Lower Limb Ischemia
Vascular, 2006In the Western world, peripheral vascular disease (PVD) has a high prevalence and is associated with high morbidity and mortality. More patients are presenting with critical limb ischemia (CLI), the end stage of PVD, because of an increased life expectancy owing to improved medical care. In a large percentage of these patients, lower limb amputation is
Teik K, Ho +3 more
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Hypoxia-inducible-factor-1 in trauma and critical care
Journal of Critical Care, 2017HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery.
Bogdanovski, Dorian A. +8 more
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Hypoxia-inducible factor 1 (HIF-1) in cancer
European Journal of Surgical Oncology (EJSO), 2004Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component in changing the transcriptional response of tumours under hypoxia.
M, Quintero, N, Mackenzie, P A, Brennan
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Oxygen(es) and the hypoxia-inducible factor-1.
Biological chemistry, 1997The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) heterodimeric transcription factor activated by reductions in oxygen concentration (hypoxia). Activated HIF-1 upregulates expression of genes involved in the adaptation of higher organisms to hypoxic conditions, caused by e.g.
Wenger, R H, Gassmann, M
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Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Science's STKE, 2007Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan organisms and is composed of HIF-1α and HIF-1β subunits. Under hypoxic conditions, HIF-1 regulates the transcription of hundreds of genes in a cell type–specific manner. The HIF-1α subunit is regulated by O
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Involvement of Hypoxia-Inducible Factor 1 in Pulmonary Pathophysiology
Chest, 2005Hypoxia-inducible factor (HIF)-1 is a transcription factor that is activated in response to hypoxia and growth factor/cytokine signaling via regulation of the HIF-1alpha subunit. HIF-1 has been implicated in the pathogenesis of pulmonary hypertension based on both experimental and clinical data.
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