Results 111 to 120 of about 4,538,639 (248)

Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells

, 2014
International audienceGlioblastoma multiforme (GBM) is the deadliest form of primary brain cancer. Several reports have indicated aberrant levels of βIII-tubulin (βIII-t) in human GBM.
Bernaudin, Myriam, Grandval, Alexandra, Alexandra Grandval, Leilane Cuhna-Alves, Cuhna-Alves, Leilane, Emmanuèle Lechapt-Zalcman, Bordji, Karim, Lechapt-Zalcman, Emmanuèle, Myriam Bernaudin, Karim Bordji   +9 more
core   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding.

PLoS ONE, 2014
Hypoxia-Inducible Factor (HIF) transcription factors are heterodimeric proteins involved in the regulation of oxygen homeostatis. Their upregulation has been related to several tumors with a remarkably poor clinical outcome.
Matteo Masetti, Federico Falchi, Maurizio Recanatini   +2 more
doaj   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

Spatially Configurable Conformal Sensor Integration on an Ultra‐Fine Metallic Needle for Minimally Invasive Deep‐Tissue Oxygen Monitoring

Advanced Materials Technologies, EarlyView.
A multi‐point oxygen‐sensing ultra‐fine needle (MO‐UFN) is developed by conformally integrating a lithographically patterned flexible electrochemical sensor array onto a clinical acupuncture needle. The platform preserves an approximately 0.3 mm diameter while enabling spatially resolved oxygen profiling along the insertion pathway.
Yeju Seo, Jaeho Park, Yongrok Jeong, Ji‐Hwan Ha, Junseong Ahn, Jimin Gu, Su A Park, Ilwoo Jun, Kichul Lee, Inkyu Park   +9 more
wiley   +1 more source

Proteomic alterations in response to Hypoxia Inducible Factor 2α in normoxic Neuroblastoma cells

, 2016
Hypoxia inducible factor (HIF)-2α protein expression in solid tumors promotes stem-like phenotype in cancer stem cells and increases tumorigenic potential in nonstem cancer cells.
Silvia Bresolin, Serafin, V, Andrea Scaloni, Flora Cimmino, CAPASSO, Mario, Scaloni A, Basso, G, PEZONE, LUCIA, SASSI, MARIA, Lucia Pezone, Marianna Avitabile, Vitale, M, Nicola Zambrano, CIMMINO, FLORA, Bresolin, S, ZAMBRANO, NICOLA, Achille Iolascon, VITALE, MARCO, IOLASCON, ACHILLE, Scaloni, A, Basso G, Sassi, M, Pezone L, AVITABILE, MARIANNA, Persano, L, Serafin V, Mauro Sassi, Mario Capasso, Capasso M, Valentina Serafin, Bresolin S, Giuseppe Basso, Cimmino F, Zambrano N, Iolascon A, Luca Persano, Avitabile M, Monica Vitale, Persano L, Vitale M, Sassi M   +40 more
core   +2 more sources

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

The Association Between Hypoxia Improvement and Electroconvulsive Therapy for Major Depressive Disorder

Neuropsychiatric Disease and Treatment, 2021
Zhida Bian,1,2,* Hui Li,3,4,* Yanlong Liu,5,* Yanjun Cao,2 Yanxia Kang,2 Yongjun Yu,2 Feng Zhang,1,2 Cunbao Li,1 Yimin Kang,1 Fan Wang2,4 1Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot, 010110, People’s ...
Bian Z, Li H, Liu Y, Cao Y, Kang Y, Yu Y, Zhang F, Li C, Kang Y, Wang F   +9 more
doaj  

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source