Results 91 to 100 of about 4,538,639 (248)

Hypoxia Inducible Factor 1α and Hypoxia Inducible Factor 2α Play Distinct and Functionally Overlapping Roles in Oral Squamous Cell Carcinoma

, 2010
Purpose: This study aimed to investigate the functional difference between hypoxia inducible factor (HIF)-1α and HIF-2α in oral squamous cell carcinomas (OSCC).
Xin-hua Liang, Ya-ling Tang, Si-xiu Chen, Ling Li, Gui-quan Zhu, Min Zheng, Jian Jiang, Xiao-yu Li   +7 more
core   +1 more source

Estrogen-dependent downregulation of hypoxia-inducible factor (HIF)-2α in invasive breast cancer cells [PDF]

, 2016
The involvement of estrogen (E2) and hypoxia in tumor progression is well established. Hypoxia has been reported to activate and degrade estrogen receptor alpha (ERα) in breast cancer cells.
Santambrogio, Sara, Wenger, Roland H, Fuady, Jerry H, Varga, Zsuzsanna; https://orcid.org/, Hoogewijs, David; https://orcid.org/, Gutsche, Katrin, Gutsche K, Santambrogio S, Hoogewijs D, Fuady JH, Wenger RH, Varga Z   +11 more
core   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways

Ecotoxicology and Environmental Safety
PCB126, a type of polychlorinated biphenyl (PCB), is a persistent pollutant found in both biotic and abiotic environments and poses significant public health risks due to its potential to cause cardiac damage with prolonged exposure.
Long Chen, Li-Jian Chen, Hong-Wu Shen, Clare HSU, Jia-Hao Zeng, Jia-Hao Li, Jia-Li Liu, Jian-Zheng Yang, Yi Liu, Xiu-Wen Li, Xiao-Li Xie, Qi Wang, Dong Zhao   +12 more
doaj   +1 more source

The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.

PLoS ONE, 2015
Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1).
Rui Chen, Min Xu, Jason S Nagati, Richard T Hogg, Alok Das, Robert D Gerard, Joseph A Garcia   +6 more
doaj   +1 more source

Hypoxia-inducible factor-2α correlates to distant recurrence and poor outcome in invasive breast cancer

, 2008
Differential regulation as well as target gene specificity of the two hypoxia-inducible factor (HIF)-α subunits HIF-1α and HIF-2α in various tumors and cell lines have been suggested.
Påhlman, Sven, Mengelbier, Linda Holmquist, Bridges Baxter, Esther, Jirström, Karin, Landberg, Göran, Larsson, Anna-Maria, Larsson, Anna Maria, Bridges, Esther, Fredlund, Erik, Holmquist Mengelbier, Linda, Helczynska, Karolina, Borgquist, Signe, Larsson, Anna-Maria,, Jirström, Karin,, Holmquist Mengelbier, Linda,, Bridges Baxter, Esther,, Fredlund, Erik,, Borgquist, Signe,, Landberg, Göran,, Helczynska, Karolina,, Lund University., Påhlman, Sven,   +21 more
core   +1 more source

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Regulation of the Rgs4 gene by the hypoxia inducible factors. [PDF]

, 2012
The transcriptional response to hypoxia is critically dependent on the Hypoxia Inducible Factors HIF-1 and HIF-2, which have roles not only in development and cellular adaptation to low oxygen levels, but also in diseases such as cancer.
Olechnowicz, Sam
core  

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source