Results 81 to 90 of about 4,538,639 (248)

Additional file 2 of Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

, 2021
Additional file 2. Figure S1. Prolyl hydroxylase domain inhibitor induces hypoxia-inducible factor 1α and hypoxia-inducible factor 2α in C3H10T1/2 cells. Figure S2.
Chun-Yuan Chen (1633390), Yung-Ming Chen (141744), Szu-Yu Pan (5948237), Chih-Jen Wu (769646), Hsing-Chen Tsai (740499), Fan-Chi Chang (384678), Wen-Chih Chiang (282507), Yu-Hsiang Chou (6067517), Yi-Ting Chen (331479), Shuei-Liong Lin (11633877), Hong-Mou Shih (4538464)   +10 more
core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

HIF-1α and HIF-2α: synergistic regulation of glioblastoma malignant progression during hypoxia and apparent chemosensitization in response to hyperbaric oxygen

Cancer Cell International
Glioblastoma multiforme (GBM), the most malignant type of brain tumour, is regulated mainly by a hypoxic microenvironment. Previous studies have focused mainly on the effects of hypoxia inducible factor-1α (HIF-1α) or hypoxia inducible factor-2α (HIF-2α)
Pan Wang, Sheng Gong, Bin Liao, Jie Liu, Lu Zhao, Nan Wu   +5 more
doaj   +1 more source

HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways

Journal of Experimental & Clinical Cancer Research, 2018
Background Hypoxic tumor microenvironment and maintenance of stemness contribute to drug resistance in breast cancer. However, whether Hypoxia-inducible factor-2α (HIF-2α) in hypoxic tumor microenvironment mediates conversion to a stem cell phenotype and
Yuanyuan Yan, Fangxiao Liu, Li Han, Lin Zhao, Jianjun Chen, Olufunmilayo I Olopade, Miao He, Minjie Wei   +7 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors

Cell Reports, 2019
Summary: Hypoxia plays a major role in the physiology of hematopoietic and immune niches. Important clues from works in mouse have paved the way to investigate the role of low O2 levels in hematopoiesis. However, whether hypoxia impacts the initial steps
Sara Chabi, Benjamin Uzan, Irina Naguibneva, Julien Rucci, Lucine Fahy, Julien Calvo, Marie-Laure Arcangeli, Frédéric Mazurier, Françoise Pflumio, Rima Haddad   +9 more
doaj   +1 more source

HIF-2α and HIF-2β immunohistochemical expression in the kidney.

, 2015
Kidney immunohistochemical expression of HIF-2α (A) and HIF-2β (B) in the renal cortex of sham (1) and CRF (2) rats and corresponding Quick scores (3). Results are presented as mean ± SEM: ***- p < 0.001 versus Sham group.
Helena Vala (721720), João Fernandes (573142), Flávio Reis (721721), Petronila Rocha-Pereira (573147), Elísio Costa (573143), Elsa Bronze-da-Rocha (573141), Sandra Ribeiro (721719), Luís Belo (573138), Patrícia Garrido (721718), Alice Santos-Silva (573149)   +9 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Hypoxia-inducible factors link inflammation and lipid metabolism in atherosclerotic macrophages

Frontiers in Cardiovascular Medicine
Atherosclerosis is a chronic inflammatory disease driven by a complex interplay between immune cells, inflammation, metabolic dysfunction, and hypoxia. Among immune cells, macrophages interact bidirectionally with these factors, undergoing phenotypic and
Kyu Seong Park, Yu Jin Ko, Jae-Hoon Choi
doaj   +1 more source

Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice.

PLoS ONE, 2013
Iron and copper are essential trace metals, actively absorbed from the proximal gut in a regulated fashion. Depletion of either metal can lead to anemia.
Pavle Matak, Sara Zumerle, Maria Mastrogiannaki, Souleiman El Balkhi, Stephanie Delga, Jacques R R Mathieu, François Canonne-Hergaux, Joel Poupon, Paul A Sharp, Sophie Vaulont, Carole Peyssonnaux   +10 more
doaj   +1 more source