Results 71 to 80 of about 4,538,639 (248)

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

, 2014
Neutrophil lifespan and function are regulated by hypoxia via components of the hypoxia inducible factor (HIF)/von Hippel Lindau/hydroxylase pathway, including specific roles for HIF-1α and prolyl hydroxylase-3.
Melanie J. Percy, Selina Parmar, Eamsamarng, Suttida, Philip M. Elks, Fredericus J. Van Eeden, Sarah R. Walmsley, Higgins, Kathryn R, Suttida Eamsamarng, Peter A. Robbins, Shaw, Gary, Parmar, Selina, Marriott, Helen M, A. A. Roger Thompson, Chilvers, Edwin R, McGrath, Emmet E, Emmet E. McGrath, David H. Dockrell, Christopher W. Pugh, Pugh, Christopher W, Kathryn R. Higgins, Kinnula, Vuokko L, Dockrell, David H, Robbins, Peter A, Vuokko L. Kinnula, Elks, Philip M, Gary Shaw, Federico Formenti, Formenti, Federico; id_orcid, Whyte, Moira K B, Thompson, A A Roger, Johnson, Randall S, Moira K. B. Whyte, Renshaw, Stephen A, Edwin R. Chilvers, Ian Sabroe, Lewis, Amy, Lynne Williams, Stephen A. Renshaw, Walmsley, Sarah R, M. Celeste Simon, Williams, Lynne, Sabroe, Ian, Helen M. Marriott, Van Eeden, Fredericus J, Amy Lewis, Percy, Melanie J, Simon, M Celeste, Randall S. Johnson   +47 more
core   +2 more sources

Microarray analysis of pathways involved in bladder cancer invasion and metastasis. [PDF]

, 2008
MDHypoxia-inducible genes have been linked to the aggressive phenotype of cancer. However, nearly all work on hypoxia-regulated genes has been conducted in vitro on cell lines.
Ord, Jonathan J
core   +2 more sources

Lipid droplet associated protein HILPDA promotes hypoxia-induced ferroptosis by driving LPCAT3-mediated polyunsaturated phospholipids enrichment.

PLoS ONE
Each year, tens of millions of individuals sojourn to high-altitude environments (>2500 m), where they face the significant physiological challenge of hypoxia, a condition that often induces a range of gastrointestinal disorders.
Zhenmei Song, Wenli Li, Jie Zeng, Xuexin Wang, Dezhi Wang, Xingchen Liao   +5 more
doaj   +1 more source

Hypoxia-inducible factor 2α mediates nonesterified fatty acids and hypoxia-induced lipid accumulation in bovine hepatocytes

Journal of Dairy Science
: Ketosis is a metabolic disorder frequently occurring in the perinatal period, characterized by elevated circulating concentrations of nonesterified fatty acids (NEFA) due to negative energy balance, resulting in fatty liver in dairy cows.
Fanrong Kong, Lin Lei, Lin Cai, Jinxia Li, Chenchen Zhao, Menglin Liu, Dandan Qi, Jie Gao, Enzhu Li, Wenwen Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei Li   +13 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils [PDF]

, 2012
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic ...
Claire L Streatfield, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Streatfield, Claire L., Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Streatfield Claire L., Yasinska Inna, Sumbayev Vadim V., Inna Yasinska, Oniku Abraham E., Gibbs Bernhard F., Abraham E Oniku   +14 more
core   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

HIF-α/MIF and NF-κB/IL-6 Axes Contribute to the Recruitment of CD11b+Gr-1+ Myeloid Cells in Hypoxic Microenvironment of HNSCC

Neoplasia: An International Journal for Oncology Research, 2014
CD11b+Gr-1+ myeloid cells have gained much attention due to their roles in tumor immunity suppression as well as promotion of angiogenesis, invasion, and metastases.
Guiquan Zhu, Yaling Tang, Ning Geng, Min Zheng, Jian Jiang, Ling Li, Kaide Li, Zhengge Lei, Wei Chen, Yunlong Fan, Xiangrui Ma, Longjiang Li, Xiaoyi Wang, Xinhua Liang   +13 more
doaj   +1 more source

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source