Results 91 to 100 of about 56,007 (232)

IL‐21 Loading CaMnCO3 Vitality Backpacks Boost CAR‐T Cell Synergistic Immunotherapy

Small, EarlyView.
This work designs CaMnCO3 nanoparticles loaded with IL‐21, which simultaneously alleviates the acidity and hypoxia of the tumor microenvironment, serving as vitality backpacks for CAR‐T cells. These nanoparticles consistently enhance the effectiveness of CAR‐T cell therapy against solid tumors in both low‐ and high‐dose infusion models by gradually and
Baihui Wang, Yuchan Xue, Yang Jia, Yuyao Duan, Dejun Li, Minghao Sui, Yuemin Feng, Le Wang, Han Ding, Xinyu Wang, Tianru Zhang, Yanning Sun, Huimin Liu, Jianni Qi, Jiazhi Duan, Songbo Zhao, Qiang Zhu   +16 more
wiley   +1 more source

Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome

Small Science, EarlyView.
Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu, Wenjun Xue, Guanchao Mao, Zhipeng Pei, Jingjing Li, Mingxue Sun, Xinkang Zhang, Shanshan Zhang, Songling Li, Jinfeng Cen, Kai Xiao, Ying Lu, Qingqiang Xu   +12 more
wiley   +1 more source

Single Extracellular Vesicle Profiling to Define Brain Specific Traumatic Brain Injury Induced Neuro‐Inflammation

Small Methods, EarlyView.
A highly innovative and implementable diagnostic tool for profiling microenvironmental perturbations in TBI patients by analyzing sEVs derived from glial cells circulating in the blood. This device provides a window into the injured brain and identifies neuroinflammatory signals, potentially serving as a platform for detecting highly specific brain ...
Zhen Zhang, Richard J Lobb, Rebecca E Lane, Xuan Vinh To, Xueming Niu, Fiach Antaw, Giovanni Pietrogrande, Craig Winter, Alain Wuethrich, Fatima Nasrallah, Matt Trau   +10 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Isolated asthenozoospermia: What should we know? A narrative review of literature

UroPrecision, EarlyView.
ABSTRACT Male infertility contributes to 20%–70% of infertile couple cases worldwide. One of the key challenges in this area is asthenozoospermia or reduced sperm motility. A particular subset, known as isolated asthenozoospermia (iASZ), in which low motility occurs without abnormalities in sperm count or shape, often goes unnoticed and is not well ...
Ahmed Eissa, Khaled Almekaty, Ahmed Zoeir, Hussein Mamdoh, Ayman Mousa, Mohammed Abou‐elenein, Tarek Gameel, Maged Ragab   +7 more
wiley   +1 more source

Network expression analysis identifies and experimentally validates the involvement of Fosb in acute kidney injury

FASEB BioAdvances, Volume 7, Issue 4, April 2025.
In this study, we used bioinformatics and in vitro and in vivo validations to discover the close association of Fosb with AKI, which was significantly upregulated in AKI. Furthermore, Fosb promoted apoptosis through AP‐1 signaling pathway‐mediated inflammatory responses in renal tubular epithelial cells, suggesting that it has the potential to be a ...
Xiaoyan Tang, Changqiong Shen, Chunqiu Liu, Jianya Gao   +3 more
wiley   +1 more source

Evaluating the Therapeutic Potential of Superoxide Dismutase in a Rat Model of Wet Age‐Related Macular Degeneration

FASEB BioAdvances, EarlyView.
Oral Superoxide Dismutase Therapy Mitigates Choroidal Neovascularization in a Laser‐Induced Rat Model of Wet Age‐Related Macular Degeneration. Oral Administration of GF103, a Superoxide Dismutase From Bacillus amyloliquefaciens, Reduces Choroidal Neovascularization (CNV) in a Laser‐Induced CNV Rat Model.
Hyun Chul Jeong, Chang Sik Cho, Jeong Hyun Kim, Inik Chang, Jeong Hun Kim   +4 more
wiley   +1 more source

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, EarlyView.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source

Different parts of the mussel Gigantidas haimaensis holobiont responded differently to deep‐sea sampling stress

Integrative Zoology, EarlyView.
Symbiotic gill and nonsymbiotic mantle of mussel Gigantidas haimaensis responded differently to deep‐sea sampling stress caused by acute environmental changes. Sharply increased transcription factors potentially play key roles in initiating the response of sampled deep‐sea macrobenthos to the sampling stress.
Guoyong YAN, Tong WEI, Yi LAN, Ting XU, Peiyuan QIAN   +4 more
wiley   +1 more source

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments

Aging Cell, EarlyView.
The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel, J. Candia, C. Ubaida‐Mohien, T. Tanaka, A. Z. Moore, M. Zhu, G. Fantoni, S. Church, J. D'Agostino, J. Fan, N. Shehadeh, S. De, E. Lehrmann, M. Kaileh, E. Simonsick, R. Sen, J. M. Egan, L. Ferrucci   +17 more
wiley   +1 more source