Results 91 to 100 of about 65,592 (181)

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia [PDF]

, 2018
The adaptive cellular response to low oxygen tensions is mediated by the hypoxia inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and β subunits.
Bridge, Katherine S., Chang, Ting-Yu, Chelala, Claude, Curry, Sean, Davidson, Kathryn M., Foster, John G., Foxler, Daniel E., Gadaleta, Emanuela, Graham, Trevor A., Grevitt, Paul, Hermida, Miguel A., Hodivala-Dilke, Kairbaan M., Kennedy, Paul T., Lagos, Dimitris, Lemoine, Nicholas R., McKay, Tristan R., Nagano, Ai, Plevin, Michael J., Rajan, Prabhakar, Reynolds, Louise E., Rhys, Hefin I., Ribeiro, Paulo S., Shah, Kunal M., Sharp, Tyson V., Shaw, Peter E., Spendlove, Ian, Wang, Hsei- Wei   +26 more
core   +4 more sources

Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression

Cell Death and Disease
Although hypoxia is a well-known key driver of metabolic reprogramming in endometrial cancer (EC), its role in lactate-mediated macrophage activation remains unclear.
Shizhou Yang, Yuejiang Ma, Tingting Wu, Xiufeng Huang   +3 more
doaj   +1 more source

Immunohistochemical expression of hypoxia inducible factor-1 alpha (Hif -1α) in patients of head and neck squamous cell carcinoma

Journal of University Medical & Dental College
BACKGROUND & OBJECTIVE: Hypoxia-inducible factor-1 alpha (HIF-1α) could serve as a molecular target for therapy in head and neck squamous cell carcinoma (HNSCC).
Syeda Sadaf Kazmi, Rabia Anjum, Waqar Ali, Aman ur Rahman, Zia Us Salam Qazi, Saima Chaudhry   +5 more
doaj   +1 more source

Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level [PDF]

, 2011
Our previous study demonstrated the direct involvement of the HIF-1α subunit in the promotion of cardiac differentiation of murine embryonic stem cells (ESCs).
Au, KW, Chan, YC, Fung, ML, Lai, WH, Lee, YK, Li, RA, Ng, KM, Siu, CW, Tse, HF   +8 more
core   +1 more source

Genetic Alterations in Gastric Cancer Associated with Helicobacter pylori Infection

Frontiers in Medicine, 2017
Gastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in Mexico. Causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. Recent molecular studies
Gonzalo Castillo-Rojas, Claudia I. Rivas-Ortiz, Yolanda Lopez-Vidal, Luis Jose Rene Arredondo-Hernandez   +3 more
doaj   +1 more source

Cardiovascular comorbidities are risk factors for increased oxidative stress and DNA damage in migraine patients: a prospective cohort study

Journal of Translational Medicine
Background Migraine is a prevalent neurovascular disorder frequently linked with oxidative stress and an elevated risk of cardiovascular diseases (CVDs), particularly in patient with comorbidities.
Mustafa Gokce, Muhammed Yunus Bektay, Mustafa Uzun, Can Ulutas, Ferda Uslu, Eray Metin Guler   +5 more
doaj   +1 more source

DRP1 downregulation impairs mitophagy, driving mitochondrial ROS and SASP production in rheumatoid arthritis CD4+PD-1+T cells

Redox Biology
T cell senescence occurs in patients with rheumatoid arthritis (RA), but the specific phenotype and its contribution to tissue-destructive inflammation remain unclear. Here, we aim to investigate whether PD-1 marks pathogenic senescent CD4+T cells and to
Ziran Bai, Jinyi Ren, Jiaqing Liu, Cheng Zhang, Huina Huang, Xiangge Zhao, Xianmei Chen, Jing Wei, Jingjing Qi, Siwen Yang, Weiping Li, Yawei Tang, Guan Wang, Xia Li   +13 more
doaj   +1 more source

Activity and mechanism of naringin in the treatment of post-infectious cough

BMC Pulmonary Medicine
Objective To explore activity and mechanism of naringin in the treatment of PIC (Post-Infectious Cough) by virtue of network pharmacology and animal studies.
Yinghan Chen, Dong Wang, Meng Song, Weiqi Pan, Wenda Guan, Zifeng Yang, Shan Zhong   +6 more
doaj   +1 more source

SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]

, 2011
Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh, Chuan-Liang Kao, Sher Singh, Wan-Jiung(Wan-Chung) Hu, Yu-Ting Yen   +4 more
core   +1 more source

The role of hypoxia and complement receptor 2 or toll-like receptor 2 on B1 B cell effector function [PDF]

Master of ScienceDivision of BiologySherry D. FlemingProfessional phagocytes play a critical role in maintaining homeostasis within a host through phagocytic, microbicidal, and inflammatory activity.
Knights, Kaori
core   +1 more source