Results 71 to 80 of about 65,592 (181)

Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling

Current Issues in Molecular Biology
Eleutheroside E (EE), a natural compound, shows promise in mitigating cellular senescence—a key factor in skin aging—though its mechanisms remain incompletely understood.
Xiangyu Ma, Liu Han, Mengran Xu, Yuling Feng, Changsheng Liu, Yida Zhao, Min Zhang, Guanghua Xu, Xin Sun   +8 more
doaj   +1 more source

Assessment of HIF-1α expression and release following endothelial injury in-vitro and in-vivo [PDF]

, 2018
Background: Endothelial injury is an early and enduring feature of cardiovascular disease. Inflammation and hypoxia may be responsible for this, and are often associated with the up-regulation of several transcriptional factors that include Hypoxia ...
A Gorlach, A Lidgren, A Loboda, C Kilkenny, CM Lambert, D Tekin, DA Tulis, E Karshovska, GAA Ferns, GL Semenza, Gordon Ferns, HX Chu, HZ Imtiyaz, J Fingerle, J He, JL Formento, L Bautista, L Heikal, Lamia Heikal, LG Gao, M Kobayashi, M Xu, Manuela Mengozzi, MS Al Okail, Pietro Ghezzi, QD Ke, R Natarajan, RA Mosher, S Srinivasan, S Zhang, S-G Ong, SL Song, SR Park, TD Eubank, TD Eubank, TE Walshe, WL Li   +36 more
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Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway

Open Medicine, 2023
Endometriosis (EM) is a prevalent estrogen-dependent disorder that adversely affects the life quality of many reproductive-age women. Previous evidence has suggested the significant role of miR-429 in EM; however, its molecular mechanisms underlying EM ...
Zheng Rong, Liu Yulan, Lei Yan, Yue Yan
doaj   +1 more source

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls [PDF]

, 2013
Background: Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival.
De Vos, Martine, Ferdinande, Liesbeth, Hindryckx, Pieter, Laukens, Debby, Van Welden, Sophie   +4 more
core   +2 more sources

Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]

, 2011
Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny, Liau, Linda M, Liu, Yue, Tso, Cho-Lea, Tso, Jonathan, Yamada, Kazunari, Ye, Fei   +6 more
core   +1 more source

Mechanisms Of Hypoxia-Induced Immune Escape In Cancer And Their Regulation By Nitric Oxide

Redox Biology, 2015
The acquired ability of tumour cells to avoid destruction by immune effector mechanisms (immune escape) is important for malignant progression. Also associated with malignant progression is tumour hypoxia, which induces aggressive phenotypes such as ...
Charles Graham, Ivraym Barsoum, Judy Kim, Madison Black, Robert D. Siemens   +4 more
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Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]

, 2018
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J, Balistrieri, Angela, Black, Stephen M, Chen, Jiwang, Desai, Ankit A, Garcia, Joe GN, Gu, Yali, Makino, Ayako, Rischard, Franz, Song, Shanshan, Tang, Haiyang, Vanderpool, Rebecca, Vinjamuri, Sujana, Wang, Jian, Wang, Ziyi, Wu, Kang, Yuan, Jason X-J, Zhang, Qian, Zhou, Guofei   +18 more
core   +1 more source

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
core   +2 more sources

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.

The Journal of biological chemistry, 1998
Hypoxia-inducible expression has been demonstrated for many groups of mammalian genes, and studies of transcriptional control have revealed the existence of hypoxia-responsive elements (HREs) in the cis-acting sequences of several of these genes. These sequences generally contain one or more binding sites for a heterodimeric DNA binding complex termed ...
Wood, S, Wiesener, MS, Yeates, K, Okada, N, Pugh, C, Maxwell, P, Ratcliffe, P   +6 more
openaire   +2 more sources

Effects of Taohong Siwu Decoction on renal protection and ERK1/2/HIF-1α signaling pathway in rats with mesangial proliferative glomerulonephritis

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the therapeutic effect of Taohong Siwu Decoction （ThSwT） on mesangial proliferative nephritis （MsPGN） in rats and examine its regulatory effect on extracellular regulated protein kinase 1/2 （ERK1/2）/hypoxia inducible factor 1α （HIF-1α）
Wu Xue-bing, Ao Hua, Li Ming
doaj