Results 151 to 160 of about 229,207 (357)

Advances on hypoxia inducible factor-1

Chinese Medical Journal, 2013
Xiao-Jun, Wang, Lou-Bin, Si
openaire   +2 more sources

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Hyperpolarized 13C Spectroscopic Imaging Informs on Hypoxia-Inducible Factor-1 and Myc Activity Downstream of Platelet-Derived Growth Factor Receptor [PDF]

, 2010
Hagit Dafni, Peder E. Z. Larson, Simon Hu, Hikari A. I. Yoshihara, Christopher Ward, Humsa S. Venkatesh, Chunsheng Wang, Xiaoliang Zhang, Daniel B. Vigneron, Sabrina M. Ronen   +9 more
openalex   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Performance of the Charniak-Lease parser on biological text using different training corpora [PDF]

, 2008
POS tagging is used as the first step in many NLP workflows, although the accuracy of tag assignment frequently goes unchecked. We hypothesize that changing the training corpora for a parser will affect its POS tagging of a target corpus.
Alison V. Callahan, Michel Dumontier
core   +1 more source

Peritoneal Milky Spots Serve as a Hypoxic Niche and Favor Gastric Cancer Stem/Progenitor Cell Peritoneal Dissemination Through Hypoxia-Inducible Factor 1α [PDF]

, 2014
Zhi‐Feng Miao, Zhen-Ning Wang, Tingting Zhao, Yingying Xu, Jian Gao, Feng Miao, Huimian Xu   +6 more
openalex   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Hypoxia Inducible Factor-1 in Diabetes and Its Complications:a Comprehensive Reviewof Recent Research Advances

Guoji laonian yixue zazhi
Diabetes mellitus(DM) stands as a multifaceted metabolic disorder marked by heightened blood glucose levels and an elusive pathogenesis.Hypoxia-inducible factor-1(HIF-1) emerges as a pivotal transcription factor triggered within hypoxic environments.Its ...
Jing Cai, Leiying Qiao, Lin Hu, Songbo Fu, Chengdong Qiao   +4 more
doaj   +1 more source

Hypoxia and Leucine Deprivation Induce Human Insulin-Like Growth Factor Binding Protein-1 Hyperphosphorylation and Increase Its Biological Activity

, 2008
Maxim D. Seferovic, Rashad Ali, Hiroyasu Kamei, Suya Liu, Javad Khosravi, Steven H. Nazarian, Victor K. M. Han, Cunming Duan, Madhulika B. Gupta   +8 more
openalex   +2 more sources