Results 281 to 290 of about 649,237 (386)

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source

Two Transactivation Domains of Hypoxia-inducible Factor-1α Regulated by the MEK-1/p42/p44 MAPK Pathway

, 2002
Eunjung Lee, Sujin Yim, Seungki Lee, Hyunsung Park   +3 more
openalex   +1 more source

3-Hydroxytanshinone Inhibits the Activity of Hypoxia-Inducible Factor 1-α by Interfering with the Function of α-Enolase in the Glycolytic Pathway. [PDF]

Molecules
Son TH, Kim SH, Shin HL, Kim D, Kim HG, Choi Y, Choi SW.   +6 more
europepmc   +1 more source

Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair

Advanced Science, EarlyView.
CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu, Maria A. Toma, Jennifer Geara, Xiaowei Bian, Yongjian Chen, Lihua Luo, Qizhang Wang, Yunting Xiao, Manika Vij, Minna Piipponen, Zhuang Liu, Sho Oasa, Letian Zhang, Dörte Schlesinger, Ákos Végvári, Dongqing Li, Aoxue Wang, Vladana Vukojević, Simon J Elsässer, Pehr Sommar, Ning Xu Landén   +20 more
wiley   +1 more source

The Influence of Circulating Exosomes Derived From Younger and Older Donors on Hypoxia-Inducible Factor 1 Alpha Gene Expression and P21 Protein in Cord Blood Hematopoietic Stem Cells. [PDF]

J Hematol
Rasti Z, Afrisham R, Bahrami Vahdat E, Kashanikhatib Z, Mousavi SH, Alizadeh S.   +5 more
europepmc   +1 more source

Hypoxia-inducible factor 1, hepatocellular carcinoma and angiogenesis [PDF]

, 2010
Choi, Daskalow, Folkman, Greijer, Jiang, Jin-Wook Kim, Liu, Llovet, Melillo, Menrad, Reinacher-Schick, Rey, Semenza, Semenza, Sun, Wagner, Wang, WeiXing, Xie   +18 more
core   +2 more sources

Ruthenium Single‐Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron–Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic‐Amplified Ferroptosis

Advanced Science, EarlyView.
An atomic‐level engineered ruthenium single‐atom nanozyme is fabricated that features sufficient oxygen vacancies and electron and hole separation efficiency, which enhances response to the sono‐suppressive tumor microenvironment and induces tumor ferroptosis.
Yang Zhu, Dengliang Wang, Chengzhong Du, Tiantian Wu, Penghui Wei, Hongjia Zheng, Guanting Li, ShunZhe Zheng, Lichao Su, Lingjun Yan, Yongrui Hu, Huimin Wang, Lisen Lin, Chenyu Ding, Xiaoyuan Chen   +14 more
wiley   +1 more source

Specific Inhibition of Hypoxia-inducible Factor (HIF)-1.ALPHA. Activation and of Vascular Endothelial Growth Factor (VEGF) Production by Flavonoids

, 2003
Yuki Hasebe, Kiyoshi Egawa, Yoko Yamazaki, Setsuko Kunimoto, Yasuaki Hirai, Yoshiteru Ida, Kiyoshi Nose   +6 more
openalex   +2 more sources

Hypoxia-inducible factor 1 and breast cancer metastasis

Journal of Zhejiang University SCIENCE B, 2015
Zhaopeng Liu, G. Semenza, Huafeng Zhang
semanticscholar   +1 more source

Statement of Retraction: Knockdown of hypoxia-inducible factor 1-alpha (HIF1α) interferes with angiopoietin-like protein 2 (ANGPTL2) to attenuate high glucose-triggered hypoxia/reoxygenation injury in cardiomyocytes. [PDF]

Bioengineered
europepmc   +1 more source