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Honokiol inhibits hypoxia-inducible factor-1 pathway
International Journal of Radiation Biology, 2011Hypoxia-inducible factor-1α (HIF-1α) plays a pivotal role in the reaction of a tumour to hypoxia. In this study, we examined the inhibitory effect of a natural compound, honokiol, on HIF-1α activity and tumour growth in combination with radiation.The inhibitory effect of honokiol on hypoxia-responsive element (HRE) controlled luciferase activity and ...
Keng-Li, Lan +8 more
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Hypoxia-Inducible Factor 1 in Lower Limb Ischemia
Vascular, 2006In the Western world, peripheral vascular disease (PVD) has a high prevalence and is associated with high morbidity and mortality. More patients are presenting with critical limb ischemia (CLI), the end stage of PVD, because of an increased life expectancy owing to improved medical care.
Teik K, Ho +3 more
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Cancer Therapeutic Agents Targeting Hypoxia-Inducible Factor-1
Current Medicinal Chemistry, 2011The discovery of hypoxia-inducible factor-1 has led to a rapidly increasing understanding of the molecular mechanism of tumor hypoxia in the past two decades. Today it is generally accepted that HIF-1 plays a pivotal role in the cellular response to tumor hypoxia which represents a major obstacle to the success of radiotherapy and chemotherapy ...
R, Wang, S, Zhou, S, Li
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Cancer Therapy By Targeting Hypoxia-Inducible Factor-1
Current Cancer Drug Targets, 2010Tumors are invariably less well-oxygenated than the normal tissues from which they arose. Hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator, plays a central role in the adaptation of tumor cells to hypoxia by activating the transcription of genes, which regulate several biological processes including angiogenesis, cell proliferation ...
Y, Li, D, Ye
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Hypoxia-Inducible Factors and Sphingosine 1-Phosphate Signaling
Anti-Cancer Agents in Medicinal Chemistry, 2011Hypoxia, defined as reduced tissue oxygen concentration, is a characteristic of solid tumors and is an indicator of unfavorable diagnosis in patients. At the cellular level, the adaptation to hypoxia is under the control of two related transcription factors, HIF-1α and HIF-2α (Hypoxia-Inducible Factor), which activate expression of genes promoting ...
Olivier, Cuvillier, Isabelle, Ader
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Regulation of angiogenesis by hypoxia-inducible factor 1
Critical Reviews in Oncology/Hematology, 2006Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression.
Kiichi, Hirota, Gregg L, Semenza
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iNOS Expression Inhibits Hypoxia-Inducible Factor-1 Activity
Biochemical and Biophysical Research Communications, 2000Hypoxia-inducible factor-1 (HIF-1) activates genes important in vascular function such as vascular endothelial growth factor (VEGF), erythropoietin (EPO), and inducible nitric oxide synthase (iNOS). iNOS catalyzes the synthesis of nitric oxide (NO), a free radical gas that mediates a number of cellular processes, including regulation of gene expression,
J H, Yin, D I, Yang, G, Ku, C Y, Hsu
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HIF‐1: hypoxia‐inducible factor or dysoxia‐inducible factor?
The FASEB Journal, 2006Hypoxia‐inducible factor 1 (HIF‐1) activates the transcription of genes involved in diverse aspects of cellular and integrative physiology, including energy metabolism, cell growth, survival, invasion, migration or angiogenesis. The activity of this transcription factor is known to be increased by hypoxia, but also by a growing ...
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Hypoxia-Inducible Factor-1 Signaling System
2005Oxygen (O2) homeostasis is regulated by balancing the supply of O2 from the vasculature and O2 consumed by mitochondrial oxidative phosphorylation. If the balance of O2 is disturbed, cells are exposed to a state of either oxidative stress or oxidative depression.
Deborah Stroka, Daniel Candinas
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STAT1 represses hypoxia-inducible factor-1-mediated transcription
Biochemical and Biophysical Research Communications, 2009Tumor hypoxia is associated with tumor promotion, malignant progression, and resistance to cancer therapy. The hypoxia-induced phenotypic changes in tumors result, at least partially, from the induction of hypoxia-responsive genes, such as chemokine receptor CXCR4.
Miki, Hiroi +4 more
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