Results 341 to 350 of about 649,237 (386)

Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective

Current Hypertension Reports, 2022
Preeclampsia (PE) is a serious and distinct type of pregnancy-induced hypertension, with an incidence of 2-8% worldwide. PE is defined as pregnancy-related hypertension with proteinuria and peripheral edema after 20 weeks of gestation. Hypoxic placenta triggers the release of inflammatory and humoral substances into maternal circulation, leading to ...
Albogami, Sarah, Al-Kuraishy, Hayder, Al-Maiahy, Thabat, Al-Buhadily, Ali, Al-Gareeb, Ali, Alorabi, Mohammed, Alotaibi, Saqer, de Waard, Michel, Sabatier, Jean-Marc, Saad, Hebatallah, Batiha, Gaber El-Saber   +10 more
openaire   +3 more sources

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

Physiology, 2009
Metazoan organisms are dependent on a continuous supply of O(2) for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease.
G. Semenza
semanticscholar   +1 more source

Regulation of angiogenesis by hypoxia-inducible factor 1

Critical Reviews in Oncology/Hematology, 2006
Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression.
Kiichi Hirota, Gregg L. Semenza
openaire   +2 more sources

Hypoxia-inducible factor 1 (HIF-1) in cancer

European Journal of Surgical Oncology (EJSO), 2004
Hypoxia is a common feature of many cancers. It contributes to local and systemic tumour progression as well as potentially compromising radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component in changing the transcriptional response of tumours under hypoxia.
Marisol Quintero, N. Mackenzie, Peter A. Brennan   +2 more
openaire   +2 more sources

Hypoxia-Inducible Factor 1 in Lower Limb Ischemia [PDF]

Vascular, 2006
In the Western world, peripheral vascular disease (PVD) has a high prevalence and is associated with high morbidity and mortality. More patients are presenting with critical limb ischemia (CLI), the end stage of PVD, because of an increased life expectancy owing to improved medical care.
Daryll Baker, TK Ho, David Abraham, Carol M. Black   +3 more
openaire   +2 more sources

Regulation of Vascularization by Hypoxia‐Inducible Factor 1

Annals of the New York Academy of Sciences, 2009
Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia that are mediated by hypoxia‐inducible factor 1 (HIF‐1). In patients with peripheral arterial disease, these responses are impaired by aging and diabetes, leading to critical limb ischemia and amputation.
openaire   +3 more sources

Hypoxia‐Inducible Factor 1 Inhibitors

2007
The tremendous progress in our understanding of the molecular mechanisms underlying the presence and consequences of hypoxia in human cancers has been accompanied by renewed enthusiasm for the development of therapeutic strategies targeting hypoxic cells signaling pathways.
openaire   +3 more sources

Hypoxia-inducible-factor-1 in trauma and critical care

Journal of Critical Care, 2017
HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery.
Dorian A. Bogdanovski, Balázs Csóka, Anastasia K. Bogdanovski, Zoltán Németh, Zoltán Németh, Garrett B. Jordan, Luca Antonioli, Louis T. DiFazio, Elina R. Paul, Stefanie A. Pilip   +9 more
openaire   +4 more sources

Cancer Therapy By Targeting Hypoxia-Inducible Factor-1

Current Cancer Drug Targets, 2010
Tumors are invariably less well-oxygenated than the normal tissues from which they arose. Hypoxia-inducible factor-1 (HIF-1), a key transcriptional regulator, plays a central role in the adaptation of tumor cells to hypoxia by activating the transcription of genes, which regulate several biological processes including angiogenesis, cell proliferation ...
D. Ye, Y. Li
openaire   +3 more sources

Hypoxia-Inducible Factor-1 Signaling System

2005
Oxygen (O2) homeostasis is regulated by balancing the supply of O2 from the vasculature and O2 consumed by mitochondrial oxidative phosphorylation. If the balance of O2 is disturbed, cells are exposed to a state of either oxidative stress or oxidative depression.
Deborah Stroka, Daniel Candinas
openaire   +2 more sources