Results 11 to 20 of about 1,301,346 (361)
Hypoxia inducible factors and diabetes. [PDF]
Journal of Clinical Investigation, 2020 Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the tissues. Hypoxia inducible factors (HIFs) are critical regulators of the mammalian response to hypoxia.
J. Gunton
semanticscholar +4 more sources
Special Issue: Hypoxia-Inducible Factors: Regulation and Therapeutic Potential [PDF]
Biomedicines, 2021 Oxygen (O2) is an essential molecule [...]
Kiichi Hirota
doaj +2 more sources
Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors
Experimental and Molecular Medicine, 2018 Liver cancer: overcoming treatment resistance Targeting hypoxia-inducible factors (HIFs), regulatory proteins induced by low oxygen levels, could increase the effectiveness of sorafenib, the only systemic therapy approved for advanced liver cancer.
Carolina Méndez-Blanco +4 more
doaj +2 more sources
Hypoxia inducible factors in hepatocellular carcinoma
Oncotarget, 2017 Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors.
Chu Chen, Tao Lou
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Hypoxia and hypoxia-inducible factors in neuroblastoma [PDF]
Cell and Tissue Research, 2017 Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2 ...
S. Påhlman, S. Mohlin
semanticscholar +4 more sources
Pharmacologic Targeting of Hypoxia-Inducible Factors.
Annual Review of Pharmacology and Toxicology, 2019 Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability. HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a constitutively expressed HIF-1β subunit.
G. Semenza
semanticscholar +4 more sources
Hypoxia-Inducible Factors in Physiology and Medicine [PDF]
Cell, 2012 Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs
G. Semenza
semanticscholar +4 more sources
Hypoxia-Inducible Factors in Cancer. [PDF]
Cancer Res, 2022 Abstract Low oxygen concentrations (hypoxia) are detrimental to most species on Earth; thus, cells have evolved with adaptations allowing them to withstand transient hypoxia. As with other survival pathways, cancer cells have co-opted these mechanisms to keep up with the metabolic demands of rapid growth and proliferation in harsh tumor ...
Kim LC, Simon MC.
europepmc +3 more sources
Hypoxia-Inducible Factors and Cancer [PDF]
Current Sleep Medicine Reports, 2017 Hypoxia inducible factors (HIFs) mediate the transcription of hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we summarize the current state of knowledge about mechanisms of HIF activation in cancer, as well as downstream cancer-promoting consequences such as altered substrate metabolism, angiogenesis, and cell ...
J. Jun +4 more
semanticscholar +4 more sources
Hypoxia-Inducible Factors [PDF]
RCSB Protein Data Bank, 2019 D. Goodsell
semanticscholar +2 more sources