Results 11 to 20 of about 1,344,802 (358)
Hypoxia-Inducible Factors [PDF]
RCSB Protein Data Bank, 2019 D. Goodsell
semanticscholar +5 more sources
Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism [PDF]
Kidney Diseases, 2021 Background: The kidney requires abundant blood supply, and oxygen is transmitted by diffusion through blood vessels. Most physiological metabolism of the kidney depends on oxygen, so it is very sensitive to oxygen. An increasing pool of evidence suggests
Qiu-Yu Li +4 more
doaj +2 more sources
Pulmonary Thrombosis Promotes Tumorigenesis via Myeloid Hypoxia-Inducible Factors [PDF]
Biomolecules, 2022 Cancer patients have a greater risk of thrombosis than individuals without cancer. Conversely, thrombosis is a diagnostic predictor of cancer, but the mechanisms by which thrombosis promotes tumor propagation are incompletely understood.
Xiao Lu +3 more
doaj +2 more sources
Targeting hypoxia-inducible factors: therapeutic opportunities and challenges. [PDF]
Nat Rev Drug Discov, 2023 Yuan X +4 more
europepmc +2 more sources
Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism
Cells, 2019 Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions and elicits a number of adaptive changes that are mainly mediated at the transcriptional level by the family of hypoxia-inducible factors (HIFs).
Ilias Mylonis +2 more
doaj +2 more sources
Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors
Experimental and Molecular Medicine, 2018 Liver cancer: overcoming treatment resistance Targeting hypoxia-inducible factors (HIFs), regulatory proteins induced by low oxygen levels, could increase the effectiveness of sorafenib, the only systemic therapy approved for advanced liver cancer.
Carolina Méndez-Blanco +4 more
doaj +2 more sources
Transcriptional regulation by hypoxia inducible factors [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2014 The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia.
V. L. Dengler, M. Galbraith, J. Espinosa
semanticscholar +3 more sources
Pharmacologic Targeting of Hypoxia-Inducible Factors.
Annual Review of Pharmacology and Toxicology, 2019 Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability. HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a constitutively expressed HIF-1β subunit.
G. Semenza
semanticscholar +3 more sources
Hypoxia inducible factors in hepatocellular carcinoma
Oncotarget, 2017 Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors.
Chu Chen, Tao Lou
semanticscholar +4 more sources
Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy [PDF]
Journal of the American Society of Nephrology, 2014 Lina Nordquist +7 more
openalex +2 more sources