Results 21 to 30 of about 1,301,346 (361)
Hypoxia-Inducible Factors [PDF]
, 2022 Oxygen is an essential molecule in the production of adenosine triphosphate (ATP) in cells, and a lack of energy due to O2 deficiency makes the maintenance of biological functions and human life improbable.
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Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications
Cells, 2021 Hypoxia, a common feature of solid tumors, greatly hinders the efficacy of conventional cancer treatments such as chemo-, radio-, and immunotherapy. The depletion of oxygen in proliferating and advanced tumors causes an array of genetic, transcriptional,
Rachel Shi, Chengheng Liao, Qing Zhang
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Hypoxia and hypoxia-inducible factors in diabetes and its complications
Diabetologia, 2021 Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results
S. Catrina, Xiaowei Zheng
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Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]
PLoS ONE, 2017 Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker +4 more
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Hypoxia-Inducible Factor in Thyroid Carcinoma [PDF]
Journal of Thyroid Research, 2011 Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy.
Burrows, Natalie +4 more
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Transcriptional regulation by hypoxia inducible factors [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2014 The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia.
V. L. Dengler, M. Galbraith, J. Espinosa
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The human side of hypoxia‐inducible factor [PDF]
British Journal of Haematology, 2008 SummaryWhen humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates that the hypoxia‐inducible factor (HIF) family of transcription factors plays a central regulatory role in these homeostatic changes at both the systemic and cellular ...
Smith, T, Robbins, P, Ratcliffe, P
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Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. [PDF]
PLoS ONE, 2012 Hypoxia plays a critical role in coordinating cell survival, differentiation and death in normal embryogenesis; during limb pattern formation, hypoxia affects two key processes, chondrogenesis and cell death.
Chunwei Huang, Barbara F Hales
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Journal of Biological Chemistry, 2020 The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also harbors a large and diverse microbial population collectively called the gut microbiome (microbiota).
Rashi Singhal, Y. Shah
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Metabolic Regulation of Hypoxia-Inducible Factors in Hypothalamus
Frontiers in Endocrinology, 2021 The earliest hypoxia-inducible factor (HIF) function was to respond to hypoxia or hypoxic conditions as a transcription factor. Recent studies have expanded our understanding of HIF, and a large amount of evidence indicates that HIF has an essential ...
Dan Du +4 more
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