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Region-Dependent Responses to Oxygen-Glucose Deprivation and Melatonin in Neonatal Brain Organotypic Slices. [PDF]
Antioxidants (Basel)Beldarrain G +5 more
europepmc +1 more source
American Journal of Hematology, Volume 101, Issue 3, Page 415-417, March 2026.
Thomas Pincez
wiley +1 more source
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Autophagy in hypoxia-ischemia induced brain injury
The Journal of Maternal-Fetal & Neonatal Medicine, 2012Autophagy is an endogenous tightly regulated process responsible for the degradation of damaged and dysfunctional cellular organelles and protein aggregates. Emerging data indicate a strong and complex interaction among autophagy, apoptosis and necrosis. We studied these interactions in a neonatal model of hypoxia-ischemia (HI).
BALDUINI, WALTER +2 more
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Radionuclide Brain‐scanning in Perinatal Hypoxia/Ischemia
Developmental Medicine & Child Neurology, 1979SUMMARYRadionuclide brain‐scans employing Technetium‐99m pertechnetate were performed in the neonatal period on 85 full‐term newborns with neurological symptons secondary to perinatal hypoxia/ischemia. The brain scan was abnormal in 56 of the infants.The early neurological and developmental progress of these infants has been studied; follow‐up ...
M. John O'Brien +2 more
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Hypoxia-Ischemia Brain Damage Disrupts Brain Cholesterol Homeostasis in Neonatal Rats
Neuropediatrics, 2009The first 3 weeks of life is the peak time of oligodendrocytes development and also the critical period of cholesterol increasing dramatically in central nervous system in rats. Neonatal hypoxia-ischemia (HI) brain damage happening in this period may disturb the brain cholesterol balance as well as white matter development.To test this hypothesis ...
Z, Yu +9 more
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Antioxidant nutrients and hypoxia/ischemia brain injury in rodents
Toxicology, 2003Cerebral ischemia and recirculation cause delayed neuronal death in rodents, such as Mongolian gerbils and stroke-prone spontaneously hypertensive rats (SHRSP), which were used as an experimental stroke model. It was documented that an enhanced nitric oxide production, the occurrence of apoptosis, and an attenuated redox regulatory system contribute to
Katsumi, Ikeda +2 more
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Hypoxia Ischemia-Mediated Cell Death in Neonatal Rat Brain
Neurochemical Research, 2008The examination of Bcl-2-associated X protein (Bax) protein's role in the activation of cognate nuclear, mitochondrial and ER cell death signaling cascades and the resulting effects on cell death phenotype in the brain after neonatal hypoxia-ischemia (HI) requires an understanding of neonatal HI insult and progression, as well as, its dysfunctional ...
Martin B, Gill, J Regino, Perez-Polo
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Dexmedetomidine Postconditioning Reduces Brain Injury after Brain Hypoxia-Ischemia in Neonatal Rats
Journal of Neuroimmune Pharmacology, 2016Perinatal asphyxia can lead to death and severe disability. Brain hypoxia-ischemia (HI) injury is the major pathophysiology contributing to death and severe disability after perinatal asphyxia. Here, seven-day old Sprague-Dawley rats were subjected to left brain HI. Dexmedetomidine was given intraperitoneally after the brain HI.
Xiaoyan, Ren, Hong, Ma, Zhiyi, Zuo
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GAS5 silencing protects against hypoxia/ischemia-induced neonatal brain injury
Biochemical and Biophysical Research Communications, 2018Hypoxic/ischemic brain damage (HIBD) leads to high neonatal mortality and severe neurologic morbidity. However, the molecular mechanism of HIBD in the neonatal infant is still elusive. Long non-coding RNAs are shown as important regulators of brain development and many neurological diseases.
Rui-Bin, Zhao +4 more
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