Results 271 to 280 of about 93,068 (305)

Amelioration by glycine of brain damage in neonatal rat brain following hypoxia–ischemia

Pediatrics International, 2017
AbstractBackgroundGlycine protected adult brains against injury in an experimental model of stroke, but, because the ischemic response of neonatal brains differs from that of adult brains, we examined the neuroprotective efficacy of glycine and associated mechanisms in an experimental model of neonatal hypoxic–ischemic (HI) encephalopathy ...
Hiroko, Mori, Ken, Momosaki, Jun, Kido, Tetsuo, Naramura, Kenichi, Tanaka, Shirou, Matsumoto, Kimitoshi, Nakamura, Hiroshi, Mitsubuchi, Fumio, Endo, Masanori, Iwai   +9 more
openaire   +2 more sources

Seizures are associated with brain injury severity in a neonatal model of hypoxia–ischemia

Neuroscience, 2010
Hypoxia-ischemia is a significant cause of brain damage in the human newborn and can result in long-term neurodevelopmental disability. The loss of oxygen and glucose supply to the developing brain leads to excitotoxic neuronal cell damage and death; such over-excitation of nerve cells can also manifest as seizures.
Bjorkman, S.T., Miller, S.M, Rose, S.E., Burke, C., Colditz, P.B.   +4 more
openaire   +5 more sources

Hypoxia/Ischemia Triggers a Light Scattering Event in Rat Brain

1997
Physiologists have shown that light scattering occurs during each stimulation of brain “slabs”. Larger signals are obtained through depolarization of neurons caused by bioenergetic deficits in hypoxia/ischemia and by terminal inhibitors of cytochrome oxidase (8). In these studies we have used prolonged hypoxia and in some cases, cardiac arrest.
B, Chance, A, Mayevsky, B, Guan, Y, Zhang   +3 more
openaire   +2 more sources

Dexmedetomidine Postconditioning Reduces Brain Injury after Brain Hypoxia-Ischemia in Neonatal Rats

Journal of Neuroimmune Pharmacology, 2016
Perinatal asphyxia can lead to death and severe disability. Brain hypoxia-ischemia (HI) injury is the major pathophysiology contributing to death and severe disability after perinatal asphyxia. Here, seven-day old Sprague-Dawley rats were subjected to left brain HI. Dexmedetomidine was given intraperitoneally after the brain HI.
Xiaoyan, Ren, Hong, Ma, Zhiyi, Zuo
openaire   +2 more sources

Helium preconditioning attenuates hypoxia/ischemia-induced injury in the developing brain

Brain Research, 2011
Recent studies show helium may be one kind of neuroprotective gas. This study aimed to examine the short and long-term neuroprotective effects of helium preconditioning in an established neonatal cerebral hypoxia-ischemia (HI) model. Seven-day-old rat pups were subjected to left common carotid artery ligation and then 90 min of hypoxia (8% oxygen at 37°
Yi, Liu, Feng, Xue, Guoke, Liu, Xin, Shi, Yun, Liu, Wenwu, Liu, Xu, Luo, Xuejun, Sun, Zhimin, Kang   +8 more
openaire   +2 more sources

Are the consequences of neonatal hypoxia–ischemia dependent on animals' sex and brain lateralization?

Brain Research, 2013
Hypoxia-ischemia on 3-day-old rats (HIP3) allows the investigation of HI damage in the immature brain. HIP3 is characterized for neurological disabilities caused by white matter injury. This study investigates the relationship between animals' sex and injured hemisphere on HIP3 consequences.
E F, Sanches, N S, Arteni, E B, Scherer, J, Kolling, F, Nicola, S, Willborn, A T S, Wyse, C A, Netto   +7 more
openaire   +2 more sources

The Neonatal Brain Is Not Protected by Osteopontin Peptide Treatment after Hypoxia-Ischemia

Developmental Neuroscience, 2015
Neonatal encephalopathy due to perinatal hypoxia-ischemia (HI) is a severe condition, and current treatment options are limited. Expression of endogenous osteopontin (OPN), a multifunction glycoprotein, is strongly upregulated in the brain after neonatal HI.
Hilde J C, Bonestroo, Cora H, Nijboer, Cindy T J, van Velthoven, Frank, van Bel, Cobi J, Heijnen   +4 more
openaire   +2 more sources

Perinatal Hypoxia-Ischemia and Brain Injury

Pediatric Research, 2000
Edwards, A. D., Azzopardi, D. V.
openaire   +2 more sources

Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5)

Autophagy, 2021
Du Feng, Wenqing Zhang, Jingjing Zhang   +2 more
exaly  

Hypoxia and brain aging: Neurodegeneration or neuroprotection?

Ageing Research Reviews, 2021
Johannes Burtscher, Robert T Mallet, Martin Burtscher   +2 more
exaly