Results 261 to 270 of about 93,068 (305)
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Antioxidant nutrients and hypoxia/ischemia brain injury in rodents
Toxicology, 2003Cerebral ischemia and recirculation cause delayed neuronal death in rodents, such as Mongolian gerbils and stroke-prone spontaneously hypertensive rats (SHRSP), which were used as an experimental stroke model. It was documented that an enhanced nitric oxide production, the occurrence of apoptosis, and an attenuated redox regulatory system contribute to
Katsumi, Ikeda +2 more
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Effects of progesterone on the neonatal brain following hypoxia-ischemia
Metabolic Brain Disease, 2018Progesterone displays a strong potential for the treatment of neonatal hypoxic-ischemic encephalopathy since it has been shown to be beneficial in the treatment of the central nervous system injuries in adult animals. Here, we evaluated the effects of the administration of progesterone (10 mg/kg) in seven-days-old male Wistar rats submitted to neonatal
Rafael Bandeira, Fabres +7 more
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Free radicals, mitochondria, and hypoxia–ischemia in the developing brain
Free Radical Biology and Medicine, 2006The immature brain is particularly susceptible to free radical injury because of its poorly developed scavenging systems and high availability of iron for the catalytic formation of free radicals. Neurons are more vulnerable to free radical damage than glial cells, but oligodendrocyte progenitors and immature oligodendrocytes in very prematurely born ...
Klas, Blomgren, Henrik, Hagberg
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Pregnancy as a valuable period for preventing hypoxia‐ischemia brain damage
International Journal of Developmental Neuroscience, 2018AbstractNeonatal brain Hypoxia–Ischemia (HI) is one of the major causes of infant mortality and lifelong neurological disabilities. The knowledge about the physiopathological mechanisms involved in HI lesion have increased in recent years, however these findings have not been translated into clinical practice.
Netto, C A +4 more
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Brain MRI in global hypoxia–ischemia: a map of selective vulnerability
Acta Neurologica Belgica, 2012Hypoxic-ischemic injury to the brain is a devastating occurrence that frequently results in death or profound long-term neurologic disability. In this report, we describe the neuroradiological findings of a patient suffering from a global brain hypoxic-ischemic injury.
Luigetti, Marco +2 more
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Radionuclide Brain‐scanning in Perinatal Hypoxia/Ischemia
Developmental Medicine & Child Neurology, 1979SUMMARYRadionuclide brain‐scans employing Technetium‐99m pertechnetate were performed in the neonatal period on 85 full‐term newborns with neurological symptons secondary to perinatal hypoxia/ischemia. The brain scan was abnormal in 56 of the infants.The early neurological and developmental progress of these infants has been studied; follow‐up ...
M. John O'Brien +2 more
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Mitochondrial Impairment in the Developing Brain After Hypoxia–Ischemia
Journal of Bioenergetics and Biomembranes, 2004The pattern of cell death in the immature brain differs from that seen in the adult CNS. During normal development, more than half of the neurons are removed through apoptosis, and mediators like caspase-3 are highly upregulated. The contribution of apoptotic mechanisms in cell death appears also to be substantial in the developing brain, with a marked
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Hypoxia Ischemia-Mediated Cell Death in Neonatal Rat Brain
Neurochemical Research, 2008The examination of Bcl-2-associated X protein (Bax) protein's role in the activation of cognate nuclear, mitochondrial and ER cell death signaling cascades and the resulting effects on cell death phenotype in the brain after neonatal hypoxia-ischemia (HI) requires an understanding of neonatal HI insult and progression, as well as, its dysfunctional ...
Martin B, Gill, J Regino, Perez-Polo
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Repetitive intermittent hypoxia-ischemia and brain damage in neonatal rats
Brain and Development, 2000To know the effect of brief-repetitive intermittent hypoxia-ischemia on the development of perinatal brain damage.Seven-day-old Wistar rats underwent ligation of the unilateral common carotid artery. The animals were allocated to three groups (n=12 in each group) and exposed to 8% oxygen as follows: group A: continuous exposure for 180 min; group B ...
N, Nagata +5 more
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Hypoxia-Ischemia Brain Damage Disrupts Brain Cholesterol Homeostasis in Neonatal Rats
Neuropediatrics, 2009The first 3 weeks of life is the peak time of oligodendrocytes development and also the critical period of cholesterol increasing dramatically in central nervous system in rats. Neonatal hypoxia-ischemia (HI) brain damage happening in this period may disturb the brain cholesterol balance as well as white matter development.To test this hypothesis ...
Z, Yu +9 more
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