Results 261 to 270 of about 1,949,320 (295)

Hypoxia-Ischemia Brain Damage Disrupts Brain Cholesterol Homeostasis in Neonatal Rats

Neuropediatrics, 2009
The first 3 weeks of life is the peak time of oligodendrocytes development and also the critical period of cholesterol increasing dramatically in central nervous system in rats. Neonatal hypoxia-ischemia (HI) brain damage happening in this period may disturb the brain cholesterol balance as well as white matter development.To test this hypothesis ...
Z, Yu, S, Li, S H, Lv, H, Piao, Y H, Zhang, Y M, Zhang, H, Ma, J, Zhang, C K, Sun, A P, Li   +9 more
openaire   +2 more sources

Amelioration by glycine of brain damage in neonatal rat brain following hypoxia–ischemia

Pediatrics International, 2017
AbstractBackgroundGlycine protected adult brains against injury in an experimental model of stroke, but, because the ischemic response of neonatal brains differs from that of adult brains, we examined the neuroprotective efficacy of glycine and associated mechanisms in an experimental model of neonatal hypoxic–ischemic (HI) encephalopathy ...
Hiroko, Mori, Ken, Momosaki, Jun, Kido, Tetsuo, Naramura, Kenichi, Tanaka, Shirou, Matsumoto, Kimitoshi, Nakamura, Hiroshi, Mitsubuchi, Fumio, Endo, Masanori, Iwai   +9 more
openaire   +2 more sources

Hypoxia/Ischemia Triggers a Light Scattering Event in Rat Brain

1997
Physiologists have shown that light scattering occurs during each stimulation of brain “slabs”. Larger signals are obtained through depolarization of neurons caused by bioenergetic deficits in hypoxia/ischemia and by terminal inhibitors of cytochrome oxidase (8). In these studies we have used prolonged hypoxia and in some cases, cardiac arrest.
B, Chance, A, Mayevsky, B, Guan, Y, Zhang   +3 more
openaire   +2 more sources

Seizures are associated with brain injury severity in a neonatal model of hypoxia–ischemia

Neuroscience, 2010
Hypoxia-ischemia is a significant cause of brain damage in the human newborn and can result in long-term neurodevelopmental disability. The loss of oxygen and glucose supply to the developing brain leads to excitotoxic neuronal cell damage and death; such over-excitation of nerve cells can also manifest as seizures.
Bjorkman, S.T., Miller, S.M, Rose, S.E., Burke, C., Colditz, P.B.   +4 more
openaire   +5 more sources

Dexmedetomidine Postconditioning Reduces Brain Injury after Brain Hypoxia-Ischemia in Neonatal Rats

Journal of Neuroimmune Pharmacology, 2016
Perinatal asphyxia can lead to death and severe disability. Brain hypoxia-ischemia (HI) injury is the major pathophysiology contributing to death and severe disability after perinatal asphyxia. Here, seven-day old Sprague-Dawley rats were subjected to left brain HI. Dexmedetomidine was given intraperitoneally after the brain HI.
Xiaoyan, Ren, Hong, Ma, Zhiyi, Zuo
openaire   +2 more sources

Helium preconditioning attenuates hypoxia/ischemia-induced injury in the developing brain

Brain Research, 2011
Recent studies show helium may be one kind of neuroprotective gas. This study aimed to examine the short and long-term neuroprotective effects of helium preconditioning in an established neonatal cerebral hypoxia-ischemia (HI) model. Seven-day-old rat pups were subjected to left common carotid artery ligation and then 90 min of hypoxia (8% oxygen at 37°
Yi, Liu, Feng, Xue, Guoke, Liu, Xin, Shi, Yun, Liu, Wenwu, Liu, Xu, Luo, Xuejun, Sun, Zhimin, Kang   +8 more
openaire   +2 more sources

Expression of Nogo-A and NgR in the developing rat brain after hypoxia–ischemia

Brain Research, 2006
Nogo-A and its receptor, NgR, have been shown to inhibit neurite growth in the adult rat. Therefore, we hypothesized that Nogo-A and NgR will be upregulated and thus play a similar role in the damage in developing rat brain following hypoxia-ischemia (HI). To test this hypothesis, we subjected postnatal day 7 (P7) rats to HI by permanently ligating the
Hua, Wang, Yujia, Yao, Xiangning, Jiang, Dapeng, Chen, Ying, Xiong, Dezhi, Mu   +5 more
openaire   +2 more sources

Brain oxidative damage in murine models of neonatal hypoxia/ischemia and reoxygenation

Free Radical Biology and Medicine, 2019
The brain is one of the main organs affected by hypoxia and reoxygenation in the neonatal period and one of the most vulnerable to oxidative stress. Hypoxia/ischemia and reoxygenation leads to impairment of neurogenesis, disruption of cortical migration, mitochondrial damage and neuroinflammation.
Torres Cuevas, Isabel, Corral-Debrinski, Marisol, Gressens, Pierre   +2 more
openaire   +4 more sources

Effects of erythropoietin on neonatal hypoxia–ischemia brain injury in rat model

Physiology & Behavior, 2017
Hypoxic-ischemic (HI) injury to the developing brain remains a major cause of morbidity. To date, few therapeutic strategies could provide complete neuroprotection. Erythropoietin (EPO) has been shown to be beneficial in several models of neonatal HI.
Qing, Ren, Zhong-Hui, Jiang, Xing-Fang, Zhang, Qiao-Zhi, Yang   +3 more
openaire   +2 more sources

Perinatal Hypoxia-Ischemia and Brain Injury

Pediatric Research, 2000
Edwards, A. D., Azzopardi, D. V.
openaire   +2 more sources