Results 271 to 280 of about 112,633 (288)

Free radicals, mitochondria, and hypoxia–ischemia in the developing brain

Free Radical Biology and Medicine, 2006
The immature brain is particularly susceptible to free radical injury because of its poorly developed scavenging systems and high availability of iron for the catalytic formation of free radicals. Neurons are more vulnerable to free radical damage than glial cells, but oligodendrocyte progenitors and immature oligodendrocytes in very prematurely born ...
Klas, Blomgren, Henrik, Hagberg
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Mitochondrial Impairment in the Developing Brain After Hypoxia–Ischemia

Journal of Bioenergetics and Biomembranes, 2004
The pattern of cell death in the immature brain differs from that seen in the adult CNS. During normal development, more than half of the neurons are removed through apoptosis, and mediators like caspase-3 are highly upregulated. The contribution of apoptotic mechanisms in cell death appears also to be substantial in the developing brain, with a marked
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Effects of progesterone on the neonatal brain following hypoxia-ischemia

Metabolic Brain Disease, 2018
Progesterone displays a strong potential for the treatment of neonatal hypoxic-ischemic encephalopathy since it has been shown to be beneficial in the treatment of the central nervous system injuries in adult animals. Here, we evaluated the effects of the administration of progesterone (10 mg/kg) in seven-days-old male Wistar rats submitted to neonatal
Rafael Bandeira, Fabres, Luciana Abreu, da Rosa, Samir Khal, de Souza, Ana Lucia, Cecconello, Amanda Stapenhorst, Azambuja, Eduardo Farias, Sanches, Maria Flavia Marques, Ribeiro, Luciano Stürmer, de Fraga   +7 more
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Repetitive intermittent hypoxia-ischemia and brain damage in neonatal rats

Brain and Development, 2000
To know the effect of brief-repetitive intermittent hypoxia-ischemia on the development of perinatal brain damage.Seven-day-old Wistar rats underwent ligation of the unilateral common carotid artery. The animals were allocated to three groups (n=12 in each group) and exposed to 8% oxygen as follows: group A: continuous exposure for 180 min; group B ...
N, Nagata, M, Saji, T, Ito, S, Ikeno, H, Takahashi, N, Terakawa   +5 more
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Pregnancy as a valuable period for preventing hypoxia‐ischemia brain damage

International Journal of Developmental Neuroscience, 2018
AbstractNeonatal brain Hypoxia–Ischemia (HI) is one of the major causes of infant mortality and lifelong neurological disabilities. The knowledge about the physiopathological mechanisms involved in HI lesion have increased in recent years, however these findings have not been translated into clinical practice.
Netto, C A, Sanches, E F, Odorcyk, F, Duran-Carabali, L E, Sizonenko, Stéphane   +4 more
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Brain MRI in global hypoxia–ischemia: a map of selective vulnerability

Acta Neurologica Belgica, 2012
Hypoxic-ischemic injury to the brain is a devastating occurrence that frequently results in death or profound long-term neurologic disability. In this report, we describe the neuroradiological findings of a patient suffering from a global brain hypoxic-ischemic injury.
Luigetti, Marco, Goldsberry, Gt, Cianfoni, Alessandro   +2 more
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Hypoxia/Ischemia Triggers a Light Scattering Event in Rat Brain

1997
Physiologists have shown that light scattering occurs during each stimulation of brain “slabs”. Larger signals are obtained through depolarization of neurons caused by bioenergetic deficits in hypoxia/ischemia and by terminal inhibitors of cytochrome oxidase (8). In these studies we have used prolonged hypoxia and in some cases, cardiac arrest.
B, Chance, A, Mayevsky, B, Guan, Y, Zhang   +3 more
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Amelioration by glycine of brain damage in neonatal rat brain following hypoxia–ischemia

Pediatrics International, 2017
AbstractBackgroundGlycine protected adult brains against injury in an experimental model of stroke, but, because the ischemic response of neonatal brains differs from that of adult brains, we examined the neuroprotective efficacy of glycine and associated mechanisms in an experimental model of neonatal hypoxic–ischemic (HI) encephalopathy ...
Hiroko, Mori, Ken, Momosaki, Jun, Kido, Tetsuo, Naramura, Kenichi, Tanaka, Shirou, Matsumoto, Kimitoshi, Nakamura, Hiroshi, Mitsubuchi, Fumio, Endo, Masanori, Iwai   +9 more
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Helium preconditioning attenuates hypoxia/ischemia-induced injury in the developing brain

Brain Research, 2011
Recent studies show helium may be one kind of neuroprotective gas. This study aimed to examine the short and long-term neuroprotective effects of helium preconditioning in an established neonatal cerebral hypoxia-ischemia (HI) model. Seven-day-old rat pups were subjected to left common carotid artery ligation and then 90 min of hypoxia (8% oxygen at 37°
Yi, Liu, Feng, Xue, Guoke, Liu, Xin, Shi, Yun, Liu, Wenwu, Liu, Xu, Luo, Xuejun, Sun, Zhimin, Kang   +8 more
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Neonatal hypoxia–ischemia induces sex-related changes in rat brain mitochondria

Mitochondrion, 2012
The effects of neonatal hypoxia-ischemia (HI) on energy metabolism in male and female rats were investigated, testing the hypothesis that HI-induced brain mitochondrial dysfunction could present in a dimorphic pattern. Impairment in electron transport chain complex activities at 2 and 18 h after HI was observed in cortex and hippocampus in rats of both
Simone N, Weis, Leticia F, Pettenuzzo, Rachel, Krolow, Lauren M, Valentim, Carina S, Mota, Carla, Dalmaz, Angela T S, Wyse, Carlos Alexandre, Netto   +7 more
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