Results 111 to 120 of about 409,719 (296)

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Soft Hypoxia‐Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed‐Loop Therapeutics of Chronic Wounds

Advanced Science, EarlyView.
Hypoxia‐adaptive bioelectronics based on poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polydopamine (PDA)/enzyme biocomposites couple O2‐centric biosensing with embedded O2 therapy to address oxygen‐deficient chronic wounds. Local O2 provision restores enzyme‐based metabolite sensing, while catalase‐mediated oxygen generation and
Songrui Liu, Bowen Yang, Cao Qi, Zhijie Zhou, Haochen Zou, Anjum Qureshi, Xiao Zhao, Ting Li, Li Gao, Ye Tao, Gang Song, Pingqiang Cai, Zheng Li, Zhiyuan Liu, Dianpeng Qi, Ting Wang, Lianhui Wang   +16 more
wiley   +1 more source

Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts [PDF]

, 2014
Aims: Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease.
Muhammad F Bari, Bari Muhammad F., Jing Chen, Edward W. Hillhouse (519261), Bari, Muhammad F., Raghu Adya (519258), Patel Vanlata, Bhudia, Sunil K., Edward W Hillhouse, Harpal S Randeva, Vanlata Patel, Raghu Adya, Chen Jing, Manjunath Ramanjaneya, Bee K. Tan (417731), Ramanjaneya, Manjunath, Jing Chen (4762), Patel, Vanlata H., Ramanjaneya Manjunath, Harpal S. Randeva (417734), Randeva Harpal S., Muhammad F. Bari (417733), Tan, Bee K., Adya Raghu, Adya, Raghu, Tan Bee K., Bhudia Sunil K., Randeva, Harpal S., Bee K Tan, Manjunath Ramanjaneya (519259), Sunil K Bhudia, Sunil K. Bhudia (519260), Hillhouse Edward W., Vanlata Patel (519257), Hillhouse, Edward W., Chen, Jing   +35 more
core   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Regulation of Cellular Stress Signaling in Bladder Ischemia

Research and Reports in Urology, 2020
Jing-Hua Yang,1 Yedan Li,2 Roya Azad,2 Kazem Azadzoi3 1Department of Surgery, Boston University School of Medicine, Boston, MA, USA; 2Department of Urology, VA Boston Healthcare System, Boston, MA, USA; 3Department of Urology and Department of Pathology,
Yang J, Li Y, Azad R, Azadzoi K
doaj  

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium [PDF]

, 2013
Background: While acute lung injury (ALI) contributes significantly to critical illness, it resolves spontaneously in many instances. The majority of patients experiencing ALI require mechanical ventilation.
Christoph H Borchers, Michel Mittelbronn, Thomas Packard, Kominsky, Douglas J., Bonney, Megan, Packard, Thomas, Michel Mittelbronn (307400), Eltzschig, Holger K., Holger K Eltzschig, Kelley Brodsky (448211), Mariani, Thomas J., Borchers, Christoph H., Brodsky, Kelley, Christoph H. Borchers (159697), Thomas J. Mariani (11667), Han, Jun, Eckle, Tobias, Holger K. Eltzschig (37610), Mittelbronn, Michel Guy André, Megan Bonney (462424), Thomas J Mariani, Jun Han, Douglas J Kominsky, Douglas J. Kominsky (462426), Tobias Eckle, Jun Han (231645), Kelley Brodsky, Megan Bonney, Tobias Eckle (65757), Thomas Packard (462425)   +29 more
core   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury

Scientific Reports
In neonatal hypoxic-ischemic brain injury (HIBI), a common form of perinatal brain damage associated with mortality and neurological disability, the disruption of oxygen and nutrient supply severely impacts brain metabolism.
Nora Wolff, Maria Triantafyllou, Javid Ghaemmaghami, Georgios Sanidas, Chad Everett Byrd, Gabriele Simonti, Susan Aja, Aurelie Roux, Khyzer Aziz, Evan Goldstein, Jiangyang Zhang, Allen Dale Everett, David Graham, Panagiotis Kratimenos, Ioannis Koutroulis, Frances Northington   +15 more
doaj   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source