Results 251 to 260 of about 409,719 (296)

Hypoxia/Ischemia and the pH Paradox

1996
Hydrogen ions play an important role in cellular processes. There are intimate links between energy metabolism and the control of cell and tissue acid/base balance. Control of this balance is threatened or lost during severe hypoxia or ischemia. Re-establishment of pH balance must occur before the tissue can be considered to have returned to normal ...
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Oxidant Mechanisms in Neonatal Hypoxia-Ischemia

Developmental Neuroscience, 2001
The neonatal brain appears to be selectively vulnerable to oxidative stress. Several potential mechanisms associated with altered reactive oxygen species metabolism would explain the increased susceptibility. They include increased accumulation of hydrogen peroxide with subsequent neurotoxicity. This enhanced neurotoxicity from H₂
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Progressive Multicystic Encephalopathy: Is There More Than Hypoxia-Ischemia?

Journal of Child Neurology, 2007
Progressive multicystic encephalopathy following prenatal or perinatal hypoxia-ischemia is a well-described phenomenon in the literature. The authors report on a term infant with a devastating encephalopathy and severe neuronal dysfunction immediately after delivery without a known antecedent of prenatal or perinatal hypoxia or distress.
Garten, Lars, Hueseman, Dieter, Stoltenburg-Didinger, Gisela, Felderhoff-Müser, Ursula, Weizsaecker, Katharina, Scheer, Ianina, Boltshauser, Eugen, Obladen, Michael   +7 more
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Hypoxia-ischemia and thiamine deficiency.

Clinical neuropathology, 1993
In order to test the hypothesis that Wernicke's encephalopathy is of topographic rather than of pathogenetic specificity we examined the brains of 49 patients without any evidence of chronic alcoholism. They had died at least four days after an event of severe hypoxia-ischemia.
A O, Vortmeyer, C, Hagel, R, Laas
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The role of hypoxia/ischemia preconditioning in ischemic stroke

Neuroscience
Ischemic stroke can cause damage to neurons, resulting in neurological dysfunction. The main treatments in the acute phase include intravenous thrombolysis, endovascular stent-assisted vascular thrombectomy and antiplatelet therapy. Due to the limitations of the time window and the risk of early intracranial hemorrhage, finding active treatment plans ...
Longni, Zhu, Gang, Su, Ruixin, Li, Tianfei, Ma, Wei, Chen, Jinyang, Song, Qionghui, Wu, Yang, An, Chenyu, Wang, Zhenchang, Zhang   +9 more
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Cerebral hypoxia-ischemia in immature rats: Methodological considerations

Experimental Neurology, 1988
We used a model of perinatal hypoxic/ischemic brain damage which combines unilateral common carotid artery ligation and hypoxia (8% O2). Protein synthesis inhibition and cell loss were found in the ipsilateral forebrain of 11-day-old rats when hypoxia was initiated 4 h but not 24 h after carotid ligation. [14C]Iodoantipyrine uptake studies suggest that
B E, Dwyer, R N, Nishimura, D G, Fujikawa   +2 more
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Responses of the SVZ to Hypoxia and Hypoxia/Ischemia

2006
Stroke is a devastating injury caused by interruption of the blood supply to the brain. Each year, about 700,000 people in the United States suffer a stroke incurring healthcare costs of more than $50 billion (Heart Disease and Stroke Statistics 2003 Update, 2002). While advances in the acute treatment of stroke have improved the survival rates, little
Ryan J. Felling, H. VanGuider, Michael J. Romanko, Steven W. Levison   +3 more
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Metabolic Aspects of Cerebral Hypoxia-Ischemia

1977
This communication, which is focused on changes in brain metabolism in hypoxia and ischemia, briefly summarizes results obtained in this and other laboratories during the last 4–5 years. An attempt will be made to describe the characteristic features of hypoxic hypoxia, both at normal and at reduced perfusion pressures, as well as of incomplete and ...
B. K. Siesjö, C.-H. Nordström, S. Rehncrona   +2 more
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Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia

2009
Matrix metalloproteinase enzymes (MMPs) have been implicated in the pathogenesis of cerebral ischemia (stroke) and neurodegenerative diseases. Until recently, however, the mechanism of activation of MMPs in these disorders remained unclear. Following a hypoxic-ischemic insult, we identified a novel posttranslational modification (PTM) of MMPs involving
Zezong Gu, Jiankun Cui, Stuart A. Lipton
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The biology and pathology of hypoxia-ischemia: an update.

Archivum immunologiae et therapiae experimentalis, 2005
After an hypoxic-ischemic (HI) insult, a multi-faceted complex cascade of events occurs that ultimately causes cell death and neurological damage to the central nervous system. The various cascades include, amongst others: immunological changes, such as the activation of the complement system and the generation of antibodies; increased inflammation ...
Andrew N, Clarkson, Brad A, Sutherland, Ian, Appleton   +2 more
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