Results 11 to 20 of about 1,114,410 (399)
PLoS Medicine, 2005 The mortality of critically ill patients rises steadily as the partial pressure of arterial oxygen falls below about 11 kPa (80 mm Hg). A new animal study in the May 2005 issue of PLoS Biology showing a potential benefit for hypoxia is thus a challenge ...
Bellingan, G
core +10 more sources
Altered Oxygen Utilisation in Rat Left Ventricle and Soleus after 14 Days, but Not 2 Days, of Environmental Hypoxia. [PDF]
, 2015 The effects of environmental hypoxia on cardiac and skeletal muscle metabolism are dependent on the duration and severity of hypoxic exposure, though factors which dictate the nature of the metabolic response to hypoxia are poorly understood.
Burgess, Sarah L. +3 more
core +27 more sources
Sestrin2 in hypoxia and hypoxia-related diseases [PDF]
Redox Report, 2021 Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.Methods: A review was conducted through an ...
Xiaojing Che +7 more
openaire +3 more sources
Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity [PDF]
International Neurourology Journal, 2021 Purpose Adenosine monophosphate-activated protein kinase (AMPK) is thought to inhibit cell proliferation or promote cell death, but the details remain unclear.
Tae Jin Cho +4 more
doaj +1 more source
Contribution of collagen XIII to lung function and development of pulmonary fibrosis
BMJ Open Respiratory Research, 2023 Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usually
Riitta Kaarteenaho +7 more
doaj +1 more source
Journal of Molecular Medicine, 2007 A major feature of solid tumours is hypoxia, decreased availability of oxygen, which increases patient treatment resistance and favours tumour progression. How hypoxic conditions are generated in tumour tissues and how cells respond to hypoxia are essential questions in understanding tumour progression and metastasis.
Brahimi-Horn, M Christiane +2 more
openaire +7 more sources
HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and labour [PDF]
Reproduction, 2021 Intermittent myometrial hypoxia is a normal feature of labour, as the powerful contractions compress blood vessels. In this review, we focus on the relation between hypoxia, myometrial metabolism, and contractility. We dissect how hypoxia can feedback and limit an ongoing contraction and help prevent foetal distress.
Clodagh Prendergast +2 more
openaire +2 more sources
Abdominal Aortic Occlusion and the Inflammatory Effects in Heart and Brain
Mediators of Inflammation, 2023 Background. Abdominal aortic occlusion (AAO) occurs frequently and causes ischemia/reperfusion (I/R) injury to distant organs. In this study, we aimed to investigate whether AAO induced I/R injury and subsequent damage in cardiac and neurologic tissue ...
Jun Xu +9 more
doaj +1 more source
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Signal Transduction and Targeted Therapy, 2022 Molecular oxygen (O 2 ) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia.
Zhen Luo +9 more
semanticscholar +1 more source
Nature Immunology, 2021 Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying distinct epigenetic, transcriptomic and metabolic characteristics. However, drivers of exhaustion remain poorly understood.
Nicole E. Scharping +11 more
semanticscholar +1 more source