A simple mathematical model of cyclic hypoxia and its impact on hypofractionated radiotherapy [PDF]
Medical Physics, 50, 1893-1904 (2023), 2022 There is evidence that the population of cells that experience fluctuating oxygen levels are more radioresistant than chronically hypoxic ones and hence, this population may determine radiotherapy (RT) response, in particular for hypofractionated RT, where reoxygenation may not be as prominent.
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Impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development [PDF]
Cells 9(3), 733, 2020, 2020 Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease. However, the effects that chronic hypoxic or inflammatory environments exert on cardiac pacemaker cells are poorly understood.
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Optical and magnetic resonance imaging approaches for investigating the tumour microenvironment: state-of-the-art review and future trends [PDF]
Nanotechnology, Volume 32, Number 6, 062001, 2021, 2021 The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the TME are acidosis and hypoxia, both of which are considered hallmarks of tumours as well as critical factors in response to anticancer treatments.
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Deep learning-based detection of morphological features associated with hypoxia in H&E breast cancer whole slide images [PDF]
arXiv, 2023 Hypoxia occurs when tumour cells outgrow their blood supply, leading to regions of low oxygen levels within the tumour. Calculating hypoxia levels can be an important step in understanding the biology of tumours, their clinical progression and response to treatment. This study demonstrates a novel application of deep learning to evaluate hypoxia in the
arxiv
Development of a PET/EPRI combined imaging system for assessing tumor hypoxia [PDF]
, 2021 Precise quantitative delineation of tumor hypoxia is essential in radiation therapy treatment planning to improve the treatment efficacy by targeting hypoxic sub-volumes. We developed a combined imaging system of positron emission tomography (PET) and electron para-magnetic resonance imaging (EPRI) of molecular oxygen to investigate the accuracy of PET
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Metabolomic and flux-balance analysis of age-related decline of hypoxia tolerance in Drosophila muscle tissue [PDF]
Molecular Systems Biology, 4:233:1-13, 2008, 2008 The fruit fly D. melanogaster is increasingly used as a model organism for studying acute hypoxia tolerance and for studying aging, but the interactions between these two factors are not well known. Here we show that hypoxia tolerance degrades with age in post-hypoxic recovery of whole-body movement, heart rate and ATP content.
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Hypoxia-resistance heterogeneity in tumours: the impact of geometrical characterization of environmental niches and evolutionary trade-offs. A mathematical approach [PDF]
, 2023 In the study of cancer evolution and therapeutic strategies, scientific evidence shows that a key dynamics lies in the tumor-environment interaction. In particular, oxygen concentration plays a central role in the determination of the phenotypic heterogeneity of cancer cell populations, whose qualitative and geometric characteristics are predominant ...
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DNA Methylation in hypoxia in Mycobacterium tuberculosis [PDF]
arXiv, 2022 Tuberculosis is one of the most lethal contagious diseases caused by Mycobacterium tuberculosis (MTB), in many cases, the infected did not show any symptoms, because the bacilli entered the dormant stage in granulomas. The dormant stage of MTB is also associated with higher resistance to drugs and the immune system.
arxiv
Phenotypic variation modulates the growth dynamics and response to radiotherapy of solid tumours under normoxia and hypoxia [PDF]
arXiv, 2021 In cancer, treatment failure and disease recurrence have been associated with small subpopulations of cancer cells with a stem-like phenotype. In this paper, we develop and investigate a phenotype-structured model of solid tumour growth in which cells are structured by a stemness level, which varies continuously between stem-like and terminally ...
arxiv
A flux-limited model for glioma patterning with hypoxia-induced angiogenesis [PDF]
arXiv, 2020 We propose a model for glioma patterns in a microlocal tumor environment under the influence of acidity, angiogenesis, and tissue anisotropy. The bottom-up model deduction eventually leads to a system of reaction-diffusion-taxis equations for glioma and endothelial cell population densities, of which the former infers flux limitation both in the self ...
arxiv