Results 11 to 20 of about 552,789 (215)
Sestrin2 in hypoxia and hypoxia-related diseases [PDF]
Redox Report, 2021 Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.Methods: A review was conducted through an ...
Xiaojing Che +7 more
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Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function [PDF]
Arthritis Research & Therapy, 2009 With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies.
Walmsley, SR, Chilvers, ER, Whyte, MKB
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Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis [PDF]
Cells, 2021 Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology.
Foglia Beatrice +6 more
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HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and labour [PDF]
Reproduction, 2021 Intermittent myometrial hypoxia is a normal feature of labour, as the powerful contractions compress blood vessels. In this review, we focus on the relation between hypoxia, myometrial metabolism, and contractility. We dissect how hypoxia can feedback and limit an ongoing contraction and help prevent foetal distress.
Susan, Wray +2 more
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Hypoxia and Hypoxia-Inducible Factors in Leukemias [PDF]
Frontiers in Oncology, 2016 Despite huge improvements in the treatment of leukemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukemic stem cells (LSCs) within the bone marrow, which are able to self-renew, and therefore reestablish the full tumor.
Margaux eDeynoux +4 more
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Hypoxia-inducible hydrogels [PDF]
Nature Communications, 2014 Oxygen is vital for the existence of all multicellular organisms, acting as a signalling molecule regulating cellular activities. Specifically, hypoxia, which occurs when the partial pressure of oxygen falls below 5%, plays a pivotal role during development, regeneration and cancer.
Park, Kyung Min, Gerecht, Sharon
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Frontiers in Immunology, 2022 Chronic ethanol abuse is a systemic disorder and a risk factor for acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). However, the mechanisms involved are unknown.
Wenhua Sang +6 more
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Hypoxia in Atherogenesis [PDF]
Angiology, 2016 The anoxemia theory proposes that an imbalance between the demand for and supply of oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism, and ...
Ferns, Gordon A A, Heikal, Lamia
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The Somatotropic Axis in the Sleep Apnea-Obesity Comorbid Duo
Frontiers in Endocrinology, 2020 Background: Growth hormone (GH) stimulates the production of insulin-like growth factor 1 (IGF-1) in most tissues and together GH and IGF-1 profoundly impact adipose tissue deposition, glucose metabolism and cardiovascular function.
Louis-Marie Galerneau +8 more
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Frontiers in Oncology, 2022 Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing.
Guillermo A. Martínez-Nieto +20 more
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