Results 31 to 40 of about 1,131,072 (401)
Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner [PDF]
, 2018 17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain ...
Albrecht, Marjorie +6 more
core +1 more source
Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis [PDF]
Cells, 2021 Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology.
Foglia Beatrice +6 more
openaire +4 more sources
Pulmonary Circulation, 2020 In some subjects, high-altitude hypobaric hypoxia leads to high-altitude pulmonary hypertension. The threshold for the diagnosis of high-altitude pulmonary hypertension is a mean pulmonary artery pressure of 30 mmHg, even though for general pulmonary ...
Julio Brito +2 more
doaj +1 more source
Oxydative stress in type 2 diabetic patients: involvement of HIF-1 alpha AND mTOR genes expression [PDF]
The Ukrainian Biochemical Journal, 2023 Biochemical and genetic mechanisms of oxidative stress (OS) developing in the blood of patients with type 2 Diabetes mellitus (T2DM) were studied. Twenty patients with T2DM and 10 healthy persons participated in this study.
Y. A. Saenko +5 more
doaj +1 more source
Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]
, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An +48 more
core +4 more sources
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer
Cells, 2021 Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia contributes to drug resistance in cancer through various molecular mechanisms.
Macus Hao-Ran Bao, C. C. Wong
semanticscholar +1 more source
The Influence of Body Size and Hemoglobin Multiplicity on Critical Oxygen Threshold in Red Drum (Sciaenops ocellatus) [PDF]
, 2016 Hypoxia is common in marine environments and fishes use a suite of cardiorespiratory adjustments to defend aerobic metabolism, including reducing standard metabolic rate (SMR), the minimum metabolic rate needed to sustain life at a specified temperature,
Pan, Yihang
core +1 more source
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
Molecular Cancer, 2019 Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance.
Xinming Jing +6 more
semanticscholar +1 more source
Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
Journal of Physiology, 2020 Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP levels.
S. Kierans, C. Taylor
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing
J. Korbecki +7 more
semanticscholar +1 more source