Results 111 to 120 of about 9,128 (213)

Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy

EMBO Molecular Medicine
Hypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to the neonatal brain during labor, leading to infant mortality or severe brain damage, with a global incidence of 1.5 per 1000 live births.
Laura Poupon-Bejuit, Amy Geard, Nathan Millicheap, Eridan Rocha-Ferreira, Henrik Hagberg, Claire Thornton, Ahad A Rahim   +6 more
doaj   +1 more source

Hypoxic-ischaemic encephalopathy code: A systematic review for resource-limited settings

Anales de Pediatría (English Edition)
It is estimated that 96% of infants with hypoxic-ischaemic encephalopathy (HIE) are born in resource-limited settings with no capacity to provide the standard of care that has been established for nearly 15 years in high-resource countries, which ...
Alfredo Garcia-Alix, Juan Arnaez, Gemma Arca, Miriam Martinez-Biarge   +3 more
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Inherited metabolic disorders presenting as hypoxic ischaemic encephalopathy: A case series of patients presenting at a tertiary care hospital in Pakistan

, 2019
In spite of the efforts and interventions by the Government of Pakistan and The World Health Organization, the neonatal mortality in Pakistan has declined by only 0.9% as compared to the global average decline of 2.1% between 2000 and 2010.
Yunus, Zabedah Md, Zahid, Maya, Khan, Aysha Habib, Afroze, Bushra, Chen, Bee Chin, Habib, Aysha, Steinmann, Beat, Johannes, Haberle, Md Yunus, Zabedah   +8 more
core   +1 more source

Hammersmith Infant Neurological Examination for early detection of cerebral palsy in Ethiopia: A feasibility and knowledge translation study

Developmental Medicine &Child Neurology, EarlyView.
The Hammersmith Infant Neurological Examination (HINE) can be successfully implemented in low‐resource tertiary care settings. Paediatric residents facilitated the implementation of HINE. Early detection of cerebral palsy and referral at an average age of 10.6 months in Ethiopia were achieved.
Selamenesh Tsige Legas, Atsede Teklehaimanot, Behaylu Yibe, Amber Makino, Rudaina Banihani, Amha Mekasha, Ayalew Moges, Asrat Demtse, Darcy Fehlings   +8 more
wiley   +1 more source

Clinical effectiveness of treatment with hyperbaric oxygen for neonatal hypoxic-ischaemic encephalopathy: systematic review of Chinese literature

, 2006
OBJECTIVES: To investigate the clinical effectiveness of treatment with hyperbaric oxygen for neonates with hypoxic-ischaemic encephalopathy. This treatment is frequently used in China but much less often in the West.
Liu, Z, Xiong, T, Meads, Catherine, Meads, C, Liu, Zulian   +4 more
core   +1 more source

Early neurodevelopmental outcome in newborns with mild hypoxic‐ischaemic encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Aim To describe the natural history of newborn children with mild hypoxic‐ischaemic encephalopathy in the first year of life. Method This was a multicentre, prospective observational study involving five neonatal intensive care units in an Italian region using both structured clinical and neurophysiological assessments according to the Italian Society ...
Domenico M. Romeo, Chiara Arpaia, Angelo Di Malta, Elisa Pede, Grazia Maria Cicala, Daniela Ricci, Francesca Serrao, Eugenio Mercuri, Claudia Brogna, Mild Encephalopathy Regional Network*, Giovanni Vento, Chiara Cafforio, Eleonora Scapillati, Roberta Arena, Francesca Gallini, Vita Augusta, Andrea Guzzetta   +16 more
wiley   +1 more source

Long-term outcome after hypothermia-treated hypoxic-ischaemic encephalopathy

, 2022
Hypoxic-ischaemic encephalopathy (HIE) is a major cause of acquired brain injury in newborn infants. It is a potentially life-threatening condition that leaves survivors at substantial risk of life-long debilitating sequelae including cerebral palsy ...
Katarina Frida Thérese Robertsson Grossmann (18659200)
core  

Seizures are associated with blood-brain barrier disruption in a piglet model of neonatal hypoxic-ischaemic encephalopathy

, 2019
Seizures in the neonatal period are most often symptomatic of central nervous system (CNS) dysfunction and the most common cause is hypoxic-ischaemic encephalopathy (HIE). Seizures are associated with poor long-term outcomes and increased neuropathology.
Colditz, Paul\ua0Bernard, Goasdoue, Kate, Lee, Kah\ua0Meng, Bjorkman, Stella\ua0Tracey, Wixey, Julie\ua0Anne, Chand, Kirat\ua0Kishore, Miller, Stephanie\ua0Melita   +6 more
core   +1 more source

The cerebral palsy directed acyclic graph: A structural causal model of aetiology

Developmental Medicine &Child Neurology, EarlyView.
The first international cerebral palsy directed acyclic graph (CP‐DAG) maps over 100 nodes and 370 links across biological, clinical, and social domains, offering a unified causal framework to guide research and identify knowledge gaps. Abstract Aim To describe the development of the initial version of the cerebral palsy (CP) directed acyclic graph ...
Shona Goldsmith, Sarah McIntyre, Nadia Badawi, Bernard Dan, Steven Day, Kate Himmelmann, Sandra Julsen Hollung, Bo Jacobsson, Gija Rackauskaite, Robert J. Reynolds   +9 more
wiley   +1 more source