Results 1 to 10 of about 240,846 (306)

Anti-inflammatory effects of Torin2 on lipopolysaccharide-treated RAW264.7 murine macrophages and potential mechanisms

Heliyon, 2022
Context: Torin2 has various pharmacological properties. However, its anti-inflammatory activity has not been reported. Objective: This study focused on the potential anti-inflammatory properties of Torin2 in lipopolysaccharide (LPS)-evoked RAW264.7 ...
Shanshan Wei, Ting Wang, Qi Cao, Xue Chen, Zhiyong Chu, Zhenzhen Zhang   +5 more
doaj   +1 more source

The Protective Effect and Mechanism of a Phytochemical Extract from the Wild Vegetable Shutou (Crateva unilocularis Buch.) against Acetaminophen-Induced Liver Injury in Mice

Foods, 2023
Acetaminophen (APAP) abuse is a common public health problem which can cause severe liver damage. However, strategies for dealing with this situation safely and effectively are very limited. The goal of the current work was to evaluate the protection and
Meimei Shan, Qian Ma, Yilin Sun, Fengyi Gao, Shengbao Cai   +4 more
doaj   +1 more source

The proto-oncogene bcl-3 encodes an I kappa B protein. [PDF]

Genes & Development, 1992
The bcl-3 gene product, overexpressed in chronic lymphocytic leukemia (CLL) patients with the translocation t(14;19), is a member of the I kappa B family. The bcl-3 protein is able to inhibit the DNA binding and trans-activation of authentic NF-kappa B heterodimers p50-p65 and p49-p65, as well as p50 and p49 homodimers.
L D, Kerr, C S, Duckett, P, Wamsley, Q, Zhang, P, Chiao, G, Nabel, T W, McKeithan, P A, Baeuerle, I M, Verma   +8 more
openaire   +2 more sources

Vagus nerve stimulation is a potential treatment for ischemic stroke

Neural Regeneration Research, 2023
Microglia are the brain’s primary innate immune cells, and they are activated and affect pro-inflammatory phenotype or regulatory phenotype after ischemic stroke.
Yi-Lin Liu, San-Rong Wang, Jing-Xi Ma, Le-Hua Yu, Gong-Wei Jia   +4 more
doaj   +1 more source

In silico structural and functional characterization of hypothetical proteins from Monkeypox virus

Journal of Genetic Engineering and Biotechnology, 2023
Background Monkeypox virus is a small, double-stranded DNA virus that causes a zoonotic disease called Monkeypox. The disease has spread from Central and West Africa to Europe and North America and created havoc in some countries all around the world ...
Kajal Gupta
doaj   +1 more source

Anti-Inflammatory Effect of Pineapple Rhizome Bromelain through Downregulation of the NF-B- and MAPKs-Signaling Pathways in Lipopolysaccharide (LPS)-Stimulated RAW264.7 Cells

Current Issues in Molecular Biology, 2021
Bromelain is a mixture of proteolytic enzymes derived from pineapple (Ananas comosus) fruit and stem possessing several beneficial properties, particularly anti-inflammatory activity.
Orapin Insuan, Phornphimon Janchai, Benchaluk Thongchuai, Rujirek Chaiwongsa, Supaporn Khamchun, Somphot Saoin, Wimonrut Insuan, Peraphan Pothacharoen, Waraporn Apiwatanapiwat, Antika Boondaeng, Pilanee Vaithanomsat   +10 more
doaj   +1 more source

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. [PDF]

Proceedings of the National Academy of Sciences, 1994
The induction of interferon (IFN) genes by viruses or double-stranded RNA (dsRNA) requires the assembly of a complex set of transcription factors on responsive DNA elements of IFN gene promoters. One of the factors necessary for regulating IFN-beta gene transcription is nuclear factor NF-kappa B, the activation of which is triggered by dsRNA.
A, Kumar, J, Haque, J, Lacoste, J, Hiscott, B R, Williams   +4 more
openaire   +2 more sources

RETRACTED: Assessment of 2-Pentadecyl-2-oxazoline Role on Lipopolysaccharide-Induced Inflammation on Early Stage Development of Zebrafish (Danio rerio)

Life, 2022
Lipopolysaccharide (LPS), or bacterial endotoxin, is an important virulence factor in several human and animal pathologies. Oxazoline of Palmitoylethanolamide (PEAOXA) has shown strong anti-inflammatory activity in several animal models.
Davide Di Paola, Sabrina Natale, Enrico Gugliandolo, Marika Cordaro, Rosalia Crupi, Rosalba Siracusa, Ramona D’Amico, Roberta Fusco, Daniela Impellizzeri, Salvatore Cuzzocrea, Nunziacarla Spanò, Fabio Marino, Alessio Filippo Peritore   +12 more
doaj   +1 more source

I kappa B kinase interacting protein as a promising biomarker in pan-cancer: A multi-omics analysis

Frontiers in Genetics, 2023
Background: Human chromosome 12 contains I kappa B kinase interacting protein (IKBIP) is also commonly known as IKIP. The involvement of IKBIP in the growth of tumors has only been discussed in a small number of publications.Purpose: To explore the role that IKBIP plays in the development of a wide variety of neoplasms, as well as the tumor ...
Chenyang Bi, Zhe Wang, Yafei Xiao, Ying Zhao, Runjiang Guo, Luyao Xiong, Zhiyu Ji, Yifan Li, Quanying Li, Changjiang Qin   +9 more
openaire   +3 more sources

Differential protein expressions in liver of mice exposed to light at night: a proteomics analysis

Zhongguo gonggong weisheng, 2023
ObjectiveTo screen and analyze differentially expressed proteins and their biological significance in the liver of mice exposed to light at night. MethodsTotally 16 healthy male C57BL/6J mice were randomly divided into an experimental group (n = 8 ...
Yue-fan WANG, Rong ZHANG, Shuang HU
doaj   +1 more source