Results 11 to 20 of about 240,846 (306)
The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B. [PDF]
The Plant Cell, 1997 The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis ...
J, Ryals +10 more
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Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion
Frontiers in Microbiology, 2021 Tripartite motif-containing proteins (TRIMs), exhibiting ubiquitin E3 ligase activity, are involved in regulation of not only autophagy and apoptosis but also pyrotosis and antiviral immune responses of host cells.
Xiu-Zhong Zhang +2 more
doaj +1 more source
Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus. [PDF]
The EMBO Journal, 1993 I kappa B proteins specifically inhibit the DNA binding of NF-kappa B/Rel transcription factors. An additional role as inhibitors of nuclear uptake was supposed by subcellular fractionation and enucleation experiments. Using indirect immunofluorescence labeling of cells, we show here that the DNA-binding p50 and p65 subunits of NF-kappa B, as well as ...
U, Zabel +3 more
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Folia Neuropathologica, 2020 This investigation evaluated the neuroprotective effect of melodinhenine B in a cerebral ischemia/reperfusion (I/R)-induced neuronal injury rat model.
Wei Li +6 more
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Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation [PDF]
, 1994 The NF-kappa B/Rel family of at least five transcription factor polypeptides is thought to function both as a developmental regulator in B cells and as a rapid response system in all cells. To examine this notion in more detail, we determined the protein
Baltimore, David +3 more
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The Transcription Factor NF-κB in Stem Cells and Development
Cells, 2021 NF-κB (nuclear factor kappa B) belongs to a family of transcription factors known to regulate a broad range of processes such as immune cell function, proliferation and cancer, neuroprotection, and long-term memory.
Christian Kaltschmidt +2 more
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Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways [PDF]
, 2014 The terpenoid 17-O-acetylacuminolide (AA) was shown to inhibit the production of several inflammatory mediators. However, the mechanisms by which this compound elicited its anti-inflammatory activity remain to be elucidated.
Achoui, Mouna +5 more
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PLoS ONE, 2010 BackgroundI-kappa B kinase 2 (IKK2 or IKK-beta) is one of the most crucial signaling kinases for activation of NF-kappa B, a transcription factor that is important for inflammation, cell survival and differentiation.
Kalsoom Sughra +3 more
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Pathogens, 2023 As generalist parasitoid wasps, Leptopilina heterotoma are highly successful on many species of fruit flies of the genus Drosophila. The parasitoids produce specialized multi-strategy extracellular vesicle (EV)-like structures in their venom.
Joseph Arguelles +4 more
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Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex. [PDF]
Proceedings of the National Academy of Sciences, 1993 Addition of mitogenic growth factors to quiescent cells triggers complex signal transduction cascades that result in the reprogramming of gene expression and entry into the cell cycle. We have found that an oncogenic variant of the c-Raf-1 protein kinase stimulated the expression of promoters containing NF-kappa B binding sites.
S, Li, J M, Sedivy
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