Results 261 to 270 of about 240,846 (306)

Diverse molecular mechanisms of inhibition of NF-kappa B/DNA binding complexes by I kappa B proteins.

Gene expression, 1994
The activity of the rel/NF-kappa B/dorsal family of kappa B site binding proteins is regulated by I kappa B proteins. The ankyrin repeat motif identified I kappa B family members, which include I kappa B alpha (pp40/MAD-3), I kappa B gamma, and bcl3, directly associated with kappa B site binding proteins, resulting in specific DNA-binding inhibition of
T, Léveillard, I M, Verma
openaire   +2 more sources

Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.

Journal of leukocyte biology, 1997
NF-kappa B/Rel transcription factors participate in the activation of numerous genes involved in immune regulation/inflammation including cytokines, cell surface receptors, adhesion molecules, and acute phase proteins. NF-kappa B activity is controlled by inhibitory proteins, I kappa Bs, that maintain the DNA-binding forms of NF-kappa B in an inactive ...
J, Hiscott, P, Beauparlant, P, Crepieux, C, DeLuca, H, Kwon, R, Lin, L, Petropoulos   +6 more
openaire   +2 more sources

Murine inhibitory protein-kappa B alpha negatively regulates kappa B-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophages.

The Journal of Immunology, 1994
Abstract The potential role of the inhibitory protein (I)-kappa B alpha gene in control of LPS-dependent transcription has been investigated in the murine macrophage cell line RAW 264.7. LPS-induced transcription in macrophages is believed to involve activation of members of the Rel homology family of transcription factors, and may be ...
J M, Tebo, W, Chaoqun, Y, Ohmori, T A, Hamilton   +3 more
openaire   +2 more sources

I kappa B proteins: structure, function and regulation.

Seminars in cancer biology, 1997
The Rel/NF-kappa B transcription factors represent the paradigm of regulation of transcriptional activation through sub-cellular localization. In unstimulated cells, NK-kappa B exists in an inactive state in the cytoplasm complexed to the inhibitory I kappa B molecules.
S T, Whiteside, A, Israël
openaire   +1 more source

Rel/NF-kappa B and I kappa B proteins: an overview.

Seminars in cancer biology, 1997
Rel/NF-kappa B proteins constitute a family of structurally-related transcription factors that are regulated by interaction with a family of regulatory proteins, the I kappa B proteins. In this review, we will familiarize the reader with the known Rel/NF-kappa B and I kappa B molecules, and will discuss the types of interactions that occur between ...
M J, May, S, Ghosh
openaire   +1 more source

The I kappa B proteins: members of a multifunctional family.

Trends in genetics : TIG, 1994
The I kappa B proteins bind to Rel/NF-kappa B transcription factors and modulate their activities. Although originally described only as cytoplasmic inhibitors of Rel/NF-kappa B transcription complexes, it is now clear that I kappa B proteins also have other functions.
T D, Gilmore, P J, Morin
openaire   +1 more source

I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family.

Cell, 1992
A cDNA corresponding to the 2.6 kb NF-kappa B mRNA species present in a variety of lymphoid cell lines has been molecularly cloned. The deduced 607 amino acid sequence is identical to the sequence of the C-terminal region of 110 kd NF-kappa B protein.
J, Inoue, L D, Kerr, A, Kakizuka, I M, Verma   +3 more
openaire   +1 more source

Estrogen inhibits phorbol ester-induced I kappa B alpha transcription and protein degradation.

Biochemical and biophysical research communications, 1998
Estrogen (E2) is known to prevent bone loss and the mechanism is, at least in part, mediated by inhibition of expression of cytokines such as interleukin-6 (IL-6). Expression of IL-6 is tightly regulated and the transcription factor NF kappa B can upregulate IL-6 gene expression by binding to its promoter region. NF kappa B is kept in an inactive state
W H, Sun, E T, Keller, B S, Stebler, W B, Ershler   +3 more
openaire   +1 more source

Biochemical and biophysical comparison of the human and Drosophila melanogaster I kappa B kinase protein complexes suggest structural conservation

The FASEB Journal, 2017
The IMD signaling pathway in Drosophila melanogaster is responsible for the expression of antimicrobial peptide genes in response to detection and binding of products of Gram‐negative bacterial infection at the cell membrane. Several macromolecular components of the IMD signaling pathway have
W Eric Rogers, Tom Huxford
openaire   +1 more source

Maintenance of nuclear factor-kappa B/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins.

The Journal of Immunology, 1996
Abstract Engagement of surface IgM (sIgM) on WEHI 231 murine B lymphoma cells leads to abortive activation and apoptosis, suggesting that this cell line may represent a model for tolerance. Loss of viability in these cells is preceded by an early increase in c-myc RNA levels followed by a decline below control values, implicating c-myc ...
S L, Schauer, Z, Wang, G E, Sonenshein, T L, Rothstein   +3 more
openaire   +2 more sources