Results 271 to 280 of about 240,846 (306)

Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development.

Molecular and cellular biology, 2004
Although largely involved in innate and adaptive immunity, NF-kappa B plays an important role in vertebrate development. In chicks, the inactivation of the NF-kappa B pathway induces functional alterations of the apical ectodermal ridge, which mediates limb outgrowth.
Ricardo G, Correa, Vinay, Tergaonkar, Jennifer K, Ng, Ilir, Dubova, Juan Carlos, Izpisua-Belmonte, Inder M, Verma   +5 more
openaire   +1 more source

Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins

Human Molecular Genetics, 1994
At least 110 genes are now known to be located in the 4000 kb of DNA encompassing the human major histocompatibility complex (MHC) in the chromosome band 6p21.3. Recent genomic sequence analysis of a 90 kb segment of DNA containing the tumour necrosis factor genes in the class III region of the MHC has predicted the presence of three potential exons ...
M R, Albertella, R D, Campbell
openaire   +2 more sources

Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.

Oncogene, 2000
Besides its known role as a translational controlling factor, the double stranded RNA-dependent protein kinase (PKR) is a key transcriptional regulator exerting antiviral and antitumoural activities. We have recently described that induction of NF-kappa B by PKR is involved in apoptosis commitment.
J, Gil, J, Alcamí, M, Esteban
openaire   +1 more source

G-Protein coupled receptor kinases mediate TNF alpha-induced NF kappaB signaling via direct interaction with and phosphorylation of I kappa B alpha (38.15)

The Journal of Immunology, 2009
Abstract Tumor necrosis factor-α (TNFα) is a multifunctional cytokine involved in the pathophysiology of many chronic inflammatory diseases. TNFα activation of the nuclear factor κB (NFκB) signaling pathway particularly in macrophages has been implicated in many diseases. We demonstrate here that G-protein coupled receptor kinase-2 and 5
Sonika Patial, Jiansong Luo, Katie Johanna Porter, Jeffrey L Benovic, Narayanan Parameswaran   +4 more
openaire   +1 more source

The NF-kappa B and I kappa B proteins: new discoveries and insights.

Annual review of immunology, 1996
The transcription factor NF-kappa B has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
openaire   +1 more source

Bcl-3, a member of the I kappa B proteins, has distinct specificity towards the Rel family of proteins.

Oncogene, 1993
Expression of the bcl-3 gene is demonstrated to be elevated in some B-cell chronic lymphocytic leukemias with a chromosomal translocation, t(14;19)(q32;q13.1). Bcl-3 protein has seven tandem ankyrin repeats that are also found in I kappa B proteins, inhibitors of Rel/NF kappa B transcription factors. In this paper, we demonstrate that Bcl-3 is a member
J, Inoue, T, Takahara, T, Akizawa, O, Hino   +3 more
openaire   +1 more source

The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines.

Biochemical pharmacology, 1994
NF-kappa B is a pleiotropic transcription factor which controls the expression of many genes and viruses. To date, there is good evidence, but no definitive proof, for its role in tumor formation and development of metastasis. To investigate the possibility that members of the NF-kappa B family could participate in the molecular control of the ...
V, Bours, E, Dejardin, F, Goujon-Letawe, M P, Merville, V, Castronovo   +4 more
openaire   +1 more source

Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2004
The nuclear transcription factor nuclear factor-kappa B (NF kappa B) and its inhibitor, I kappa B, regulate the transcription of various genes involved in cell proliferation, adhesion, and survival. The NF kappa B transcription factor complex plays a role in cancer development and progression through its influence on apoptosis.
Jeffrey S, Ross, Bhaskar V S, Kallakury, Christine E, Sheehan, Hugh A G, Fisher, Ronald P, Kaufman, Prabhjot, Kaur, Karen, Gray, Bradley, Stringer   +7 more
openaire   +1 more source

I kappa B-alpha-mediated inhibition of nuclear transport and DNA-binding by Rel proteins are separable functions: phosphorylation of C-terminal serine residues of I kappa B-alpha is specifically required for inhibition of DNA-binding.

Oncogene, 1995
I kappa B-alpha inhibits both DNA-binding and nuclear translocation of dimeric Rel complexes that contain either the RelA or c-Rel proteins. These inhibitory functions of I kappa B-alpha proteins are regulated by both constitutive and inducible phosphorylation.
S, Sachdev, E M, Rottjakob, J A, Diehl, M, Hannink   +3 more
openaire   +1 more source

Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation.

Oncogene, 1995
Tax protein of HTLV-1 stimulates transcription of specific cellular genes through the NF-kappa B binding site. We previously showed that Tax binds to the ankyrin motifs of I kappa B-gamma, and dissociates the I kappa B-gamma/NF-kappa B complexes, resulting in nuclear translocation of NF-kappa B proteins. We herein report the effects of Tax on I kappa B-
T, Suzuki, H, Hirai, T, Murakami, M, Yoshida   +3 more
openaire   +1 more source