Results 21 to 30 of about 240,846 (306)

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure [PDF]

, 2015
Hepatocellular carcinoma (HCC) is characterized by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which activates the unfolded protein response (UPR).
Ampe, Christophe, Bogaerts, Eliene, Descamps, Benedicte, Devisscher, Lindsey, Geerts, Anja, Govaere, O, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van den Bussche, A, Van Steenkiste, Christophe, Van Troys, Marleen, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vanhove, Christian, Verhelst, Xavier   +16 more
core   +3 more sources

Cloning of a Differentially Expressed IκB-related Protein [PDF]

Journal of Biological Chemistry, 1995
We have cloned a cDNA corresponding to a novel gene from a human epithelial cell line by subtractive hybridization and polymerase chain reaction techniques. This gene is expressed at the message level and at the protein level in a lung alveolar type II-like epithelial cell line but not in lung fibroblasts. In adult human tissues, the mRNA for this gene
P, Ray, D H, Zhang, J A, Elias, A, Ray
openaire   +2 more sources

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation [PDF]

, 2003
The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the ...
Crews, Craig M., Deshaies, Raymond J., Kim, Kyung B., Ransick, Andy, Sakamoto, Kathleen M., Stein, Bernd, Verma, Rati   +6 more
core   +1 more source

Chemical Constituents of the Mushroom Dictyophora indusiata and Their Anti-Inflammatory Activities

Molecules, 2023
As an edible and medicinal fungus, Dictyophora indusiata is well-known for its morphological elegance, distinctive taste, high nutritional value, and therapeutic properties.
Yingfang Zhang, Hang Xun, Quan Gao, Feifei Qi, Jia Sun, Feng Tang   +5 more
doaj   +1 more source

Dynamic Influence Networks for Rule-based Models [PDF]

, 2017
We introduce the Dynamic Influence Network (DIN), a novel visual analytics technique for representing and analyzing rule-based models of protein-protein interaction networks.
Boutillier, Pierre, Burks, Andrew, Fontana, Walter, Forbes, Angus G., Krivine, Jean, Lee, Kristine, Li, Xing   +6 more
core   +5 more sources

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons [PDF]

, 2016
Background: Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson's disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is mounting evidence of LRRK2 ...
Gorostidi, Ana, Lang, Valérie, López de Maturana, Rakel, López de Munain Arregui, Adolfo José, Rodríguez, Manuel, Sousa, Amaya, Sánchez-Pernaute, Rosario, Vázquez, Nerea, Zubiarrain, Amaia, Águila, Julio   +9 more
core   +2 more sources

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN. [PDF]

, 1999
A
Ballard, Bandres, Barnes, Bergmann, Beyaert, Boldin, Cao, Carpentier, Chen, Chu, Cooper, Darnay, DeLamarter, De Valck, De Valck, Dignam, Dixit, Eckner, Ferran, Fukushi, Geleziunas, Gerritsen, Harris, Henkel, Heyninck, Hsu, Hsu, Hsu, Hu, Ishida, Ishida, Jäättelä, Kelliher, Krikos, Laherty, Laherty, LeBail, Lee, Malinin, Mercurio, Min, Muzio, Natoli, Naumann, Ng, Niederman, Niwa, Opipari, Perkins, Plaisance, Reinhard, Sarma, Schreck, Semmes, Song, Southern, Uhlik, Van Antwerp, Vandenabeele, Vanden Berghe, W., S. Plaisance, E. Boone, K. De Bosscher, M.L. Schmitz, W. Fiers, and G. Haegeman, Vanhaesebroeck, Van Snick, Vincenz, Yeh, Yin, Yurochko, Zandi, Zhang, Zhong, Zhong   +69 more
core   +2 more sources

A Marine Diterpenoid Modulates the Proteasome Activity in Murine Macrophages Stimulated with LPS

Biomolecules, 2018
The proteasome is an intracellular complex that degrades damaged or unfolded proteins and participates in the regulation of several processes. The immunoproteasome is a specialized form that is expressed in response to proinflammatory signals and is ...
Yisett González, Deborah Doens, Héctor Cruz, Ricardo Santamaría, Marcelino Gutiérrez, Alejandro Llanes, Patricia L. Fernández   +6 more
doaj   +1 more source

Role of glutathionylation in infection and inflammation [PDF]

, 2019
Glutathionylation, that is, the formation of mixed disulfides between protein cysteines and glutathione (GSH) cysteines, is a reversible post-translational modification catalyzed by dierent cellular oxidoreductases, by which the redox state of the cell
Baldelli, S., Checconi, P., Ciriolo, M. R., Limongi, D., Nencioni, L., Palamara, A. T.   +5 more
core   +1 more source

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase.

The Journal of biological chemistry, 2003
Although it is well established that reactive oxygen intermediates mediate the NF-kappaB activation induced by most agents, how H2O2 activates this transcription factor is not well understood. We found that treatment of human myeloid KBM-5 cells with H2O2 activated NF-kappaB in a dose- and time-dependent manner much as tumor necrosis factor (TNF) did ...
Yasunari, Takada, Asok, Mukhopadhyay, Gopal C, Kundu, Ganapati H, Mahabeleshwar, Sujay, Singh, Bharat B, Aggarwal   +5 more
openaire   +2 more sources