Results 31 to 40 of about 240,846 (306)

Hsp90 Interacts with the Bacterial Effector NleH1

Pathogens, 2018
Enterohemorrhagic Escherichia coli (EHEC) utilizes a type III secretion system (T3SS) to inject effector proteins into host cells. The EHEC NleH1 effector inhibits the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway by
Miaomiao Wu, Philip R. Hardwidge
doaj   +1 more source

The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation. [PDF]

Genes & Development, 1991
The product of proto-oncogene Rel associates with a number of cellular proteins. We have studied the effect of one of them, a phosphoprotein of 40 kD (pp40), on the DNA-binding activity of the Rel protein. We demonstrate that purified pp40 not only inhibits the binding of Rel, but also NF-kappa B (p50-p65) heterocomplex to DNA.
L D, Kerr, J, Inoue, N, Davis, E, Link, P A, Baeuerle, H R, Bose, I M, Verma   +6 more
openaire   +2 more sources

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells [PDF]

, 2010
Nucleotide excision repair (NER) is the most versatile DNA repair system that deals with the major UV photoproducts in DNA, as well as many other DNA adducts.
Cloney, Ross, Fousteri, Maria I, Japers, Nicolaas G, Lehmann, Alan R, Limsirichaikul, Siripan, Miki, Yoshio, Mullenders., Leon H F, Nakazawa, Yuka, Niimi, Atsuko, Ogi, Tomoo, Overmeer, René M, Takenaka, Katsuya, Volker, Marcel, Yamashita, Shunichi   +13 more
core   +3 more sources

Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease [PDF]

, 2012
Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes ...
Barreto, Daniela V, Barreto, Fellype C, Eloot, Sunny, Glorieux, Griet, Lemke, Horst D, Lenglet, Aurélie, Liabeuf, Sophie, Massy, Ziad A, Neirynck, Nathalie, Vanholder, Raymond   +9 more
core   +10 more sources

Inhibitory Effect of LGS and ODE Isolated from the Twigs of Syringa oblata subsp. dilatata on RANKL-Induced Osteoclastogenesis in Macrophage Cells

Molecules, 2021
Osteoblasts and osteoclasts play a pivotal role in maintaining bone homeostasis, of which excessive bone resorption by osteoclasts can cause osteoporosis and various bone diseases.
Ga-Ram Kim, Eun-Nam Kim, Kyoung Jin Park, Ki Hyun Kim, Gil-Saeng Jeong   +4 more
doaj   +1 more source

On the dephasing of genetic oscillations

, 2013
The digital nature of genes combined with the associated low copy numbers of proteins regulating them is a significant source of stochasticity, which affects the phase of biochemical oscillations.
Potoyan, D. A., Wolynes, P. G.
core   +1 more source

Dimethyl Fumarate Targets MSK1, RSK1, 2 and IKKα/β Kinases and Regulates NF-κB /p65 Activation in Psoriasis: A Demonstration of the Effect on Peripheral Blood Mononuclear Cells, Drawn from Two Patients with Severe Psoriasis Before and After Treatment with Dimethyl Fumarate

Psoriasis: Targets and Therapy, 2020
Borbala Gesser,1 Mads K Rasmussen,1,2 Lars Iversen1,2 1Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkCorrespondence: Borbala Gesser Email gesser@post11.tele ...
Gesser B, Rasmussen MK, Iversen L
doaj  

Momordica cochinchinensis (Gấc) Seed Extracts Induce Apoptosis and Necrosis in Melanoma Cells

Pharmaceuticals, 2023
Momordica cochinchinensis is a herbal medicine used throughout Asia and this study investigated the antimelanoma potentials and molecular mechanisms of M. cochinchinensis seed with emphasis on extraction to optimise bioactivity.
Dao Nguyen, Jessica Holien, Chaitali Dekiwadia, Thilini Thrimawithana, Terrence Piva, Tien Huynh   +5 more
doaj   +1 more source

Human T-lymphotropic Virus Type I Tax Activates I-κB Kinase by Inhibiting I-κB Kinase-associated Serine/Threonine Protein Phosphatase 2A [PDF]

Journal of Biological Chemistry, 2003
I-kappa B kinase (IKK) is a serine/threonine kinase that phosphorylates I-kappa B alpha and I-kappa B beta and targets them for polyubiquitination and proteasome-mediated degradation. IKK consists of two highly related catalytic subunits, alpha and beta, and a regulatory gamma subunit, which becomes activated after serine phosphorylation of the ...
De-Xue, Fu, Yu-Liang, Kuo, Bao-Ying, Liu, Kuan-Teh, Jeang, Chou-Zen, Giam   +4 more
openaire   +2 more sources

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source