Results 171 to 180 of about 288,159 (307)

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Bridging the gap in Alzheimer's therapy: strategic design and SAR evolution of coumarin-based hybrids as potent MTDLs. [PDF]

RSC Adv
El-Mokaddem OK, Elmasry GF, Mahmoud WR, Abdel Ghany LMA.   +3 more
europepmc   +1 more source

Microbial IC50 Fold Change from Reference [PDF]

, 2020
openaire   +1 more source

IC50, MIC and MBC values of the tested compounds.

, 2015
Amélie Beury-Cirou, Tannières Mélanie, Corinne Minard, Laurent Soulère, Tsiry Rasamiravaka, Robert H. Dodd, Queneau Yves, Dessaux Yves, Guillou Catherine, Olivier M. Vandeputte (475089), Faure Denis   +10 more
openalex   +2 more sources

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Marine Natural Products as Potent Anticancer Agents (2020-2024): Structural Diversity, SARs and Target Prediction. [PDF]

Mar Drugs
Huang Z, Du Y, Hu J, Ying L, Zhou B, Hua Y, Wang H, Yang Z.   +7 more
europepmc   +1 more source

Phytochemicals Analysis and Antioxidant (IC50) Value of Dried and Fresh Mangrove (Rhizopora racemosa) Leaves Extract for Herbal Drink Base

Sutrisno Adi Prayitno, Dwi Retnaningtyas Utami, Silvy Novita Antrisna Putri   +2 more
openalex   +2 more sources

Determining the nanoBRET AL2K IC50 values of 24 new ACVR1/ALK2 inhibitors

, 2018
Jong Fu Wong, Alex
openalex   +1 more source

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Inhibition of Diabetes-Related Enzymes by Plant Secondary Metabolites: A Promising Therapeutic Strategy. [PDF]

Life (Basel)
Șeremet OC, Andrei C, Pușcașu C, Zanfirescu A, Nițulescu G, Gîrd CE, Olaru OT.   +6 more
europepmc   +1 more source