Results 151 to 160 of about 288,159 (307)

Dynamic Ranges of Detection-Coupled Assays and Their Effect on IC50 Measurements for Inhibition of Enzymatic Reactions [PDF]

, 2010
Xiaoke Yang
openalex   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Correction: Mukavi et al. Antiprotozoal Aminosteroid Alkaloids from <i>Buxus obtusifolia</i> (Mildbr.) Hutch. <i>Molecules</i> 2025, <i>30</i>, 4558. [PDF]

Molecules
Mukavi JW, Cal M, Kaiser M, Mäser P, Kimani NM, Omosa LK, Schmidt TJ.   +6 more
europepmc   +1 more source

Raw data for absorbance values from MTT assay and subsequent calculation of IC50 values (on promastigotes) for extracts of Solanum nigrum from Bungoma.

, 2018
Christine N. Mutoro, Johnson K. Kinyua, Joseph Ngángá, Daniel Kariuki, Johnstone Ingonga, Christopher O. Anjili   +5 more
openalex   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Preprocessed BindingDB drug-target affinity(IC50/Ki/Kd/EC50) dataset for construction of ConfMux-DTA model

Zhoutong Dai
openalex   +1 more source

Penentuan Aktivitas Antioksidan Berdasarkan Nilai IC50 Ekstrak Metanol dan Fraksi Hasil Partisinya pada Kulit Biji Pinang Yaki (Areca vestiaria Giseke)

, 2014
Filbert, Harry S. J. Koleangan, Max R. J. Runtuwene, Vanda S. Kamu   +3 more
openalex   +2 more sources

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Isoxazole Derivative Induces Apoptosis-like Death and Autophagy through Oxidative Stress in <i>Leishmania amazonensis</i>. [PDF]

ACS Omega
Kawano Bakoshi AB, Beltrame Machado RR, Pianoski KE, Mendes De Souza Melo S, Andreia Rosa F, Silva Lautenschlager SO, Ueda-Nakamura T, Nakamura CV, Lazarin-Bidóia D.   +8 more
europepmc   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source