Results 131 to 140 of about 417,281 (310)

In Vitro Cytotoxic Activity of Lagerstroemia speciosa (L.) Pers. Leaf Extracts against MCF-7 Breast Cancer Cells

Jurnal Ilmu dan Teknologi Kesehatan
Breast cancer is the most commonly diagnosed cancer in women, and chemotherapy is limited by toxicity and drug resistance. Bungur (Lagerstroemia speciosa (L.) Pers.) leaves contain flavonoids and other secondary metabolites that may have cytotoxic ...
Ernie Halimatushadyah, Dyah Ayuwati Waluyo, Krismayadi Krismayadi   +2 more
doaj   +1 more source

IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

, 2010
The predictive utility of two in vitro methods (empirical IC50-based and mechanistic kinact/KI) for the assessment of time-dependent cytochrome P450 3A4 (CYP3A4) inhibition has been compared.
Houston, J. Brian, Galetin, Aleksandra, Burt, Howard J.   +2 more
core   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

A Chemotherapy Response-Related Gene Signature and DNAJC8 as Key Mediators of Hepatocellular Carcinoma Progression and Drug Resistance

Journal of Hepatocellular Carcinoma
Yan Ye,1 Yanmei Zeng,1 Shenggang Huang,1,2 Chunping Zhu,1,2 Qingshui Wang3 1Ganzhou Key Laboratory of Molecular Medicine, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, People’s Republic of China; 2Department of Gastroenterology, The ...
Ye Y, Zeng Y, Huang S, Zhu C, Wang Q
doaj  

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

IC50 [PDF]

, 2008
openaire   +2 more sources

Theoretical and Experimental Relationships between %-Inhibition and IC50 Data observed in HTS

, 2012
The 4-parameter logistic Hill equation models the theoretical relationship between inhibitor concentration and %-inhibition in response, and is used to derive IC50 values as a measure of compound potency.
Gubler, Hanspeter, Schopfer, Ulrich, Hanspeter Gubler, Jacoby, Edgar, Edgar Jacoby, Ulrich Schopfer   +5 more
core   +1 more source

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source