Results 121 to 130 of about 288,159 (307)

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

DETERMINATION OF ANTIOXIDANT ACTIVITY IN OIL AND RED FRUIT JUICE (Pandanus conoideus Lamk) WITH DPPH METHOD

Al-Ulum
Antioxidant compounds play an essential role in health because they can reduce the risk of chronic diseases such as cancer and coronary heart disease. This study analyzed the antioxidant activity of red fruit oil and juice.
Ees Aisyah Al failah, Rizki Febriyanti, Wilda Amananti   +2 more
doaj   +1 more source

Asymptomatic COVID-19 re-infection in a Japanese male by elevated half-maximal inhibitory concentration (IC50) of neutralizing antibodies [PDF]

, 2021
Makoto Inada, Masahiro Ishikane, Mari Terada, Akihiro Matsunaga, Kenji Maeda, K. Tsuchiya, Kenji Miura, Yu Sairenji, Noriko Kinoshita, Mugen Ujiie, Satoshi Kutsuna, Yukihito Ishizaka, Hiroaki Mitsuya, Norio Ohmagari   +13 more
openalex   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Assessment of Cell Viability in Drug Therapy: IC50 and Other New Time-Independent Indices for Evaluating Chemotherapy Efficacy [PDF]

Marta Sánchez‐Díez, Paula Romero-Jiménez, Nicolás Alegría‐Aravena, Clara E. Gavira-O’Neill, Elena Vicente-García, Josefa Quiroz‐Troncoso, Raquel González‐Martos, Carmen Ramírez‐Castillejo, Juan Manuel Pastor   +8 more
openalex   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

First-stage Genome-wide Gene Expression Analyses of Human Mesenchymal Stem Cells Exposed to IC50 Ni (2+) ions

, 2009
Masayuki Taira, Tadayoshi Kagiya, Minoru Sasaki, Kaori Sasaki, Setsuo Saitoh, Takashi Nezu, Hidemitsu Harada, Shigenobu Kimura, Yoshima Araki   +8 more
openalex   +2 more sources

PENGARUH SUHU DAN KONSENTRASI GUM ARAB TERHADAP AKTIVITAS ANTIOKSIDAN (IC50) PADA PROSES SPRAY DRYING BAYAM HIJAU (AMARANTHUS HYBRIDUS L.)

, 2020
Ita N Awaliyah, Maziyatul Machfudloh, Anang Takwanto   +2 more
openalex   +2 more sources

Choosing the Best Second-Line Tyrosine Kinase Inhibitor in Imatinib-Resistant Chronic Myeloid Leukemia Patients Harboring Bcr-Abl Kinase Domain Mutations: How Reliable Is the IC50? [PDF]

, 2011
Simona Soverini, Gianantonio Rosti, Ilaria Iacobucci, Michele Baccarani, Giovanni Martinelli   +4 more
openalex   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source