Results 101 to 110 of about 417,281 (310)

The IC50 value of common drugs for chemotherapy and targeted therapy.

, 2023
(A) High risk score indicated a lower IC50 value of 5-fluorouracil, camptothecin, cyclophosphamide, docetaxel, gemcitabine, oxaliplatin, and paclitaxel in HCC. (B) HCC patients with high risk score had a lower IC50 value of afatinib, axitinib, crizotinib,
Qian Feng (302178), Linquan Wu (3138357), Hongcheng Lu (1351278)   +2 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

The Cytoxic Effects Of Forest Honey (Apis dorsata) On T47D Breast Cancer Cells

Magna Medika
Background: In 2018, an estimated 2 million people had breast cancer. Forest honey (Apis dorsata) can have antioxidant activity due to the presence of flavonoid saponin, alkaloid, and tannin compound, therefore can be used as anticancer through the ...
Malik Hisyam Adnan, Maya Dian Rakhmawatie, Yanuarita Tursinawati   +2 more
doaj   +1 more source

IC50 dose following treatment with DAC and Ara-C alone.

, 2014
Cells were treated at 0, 24, 48, 72 and 96 h and the IC50 measured at 120 h.
Tracey Perry (516103), Ciarán B. Woodman (5657794), Sarah M. Leonard (516102), Pamela Kearns (104106)   +3 more
core   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Study of Phytochemical, Antioxidant and Antimicrobial Activity of Artocarpus heterophyllus

Nepal Journal of Biotechnology, 2016
In today’s world, search for natural medicines is increasing as a result of drug resistance of pathogens and also due to negative consequences of antibiotic.
Nita Thapa, Pratiksha Thapa, Jay Bhandari, Prasodhan Niraula, Nikita Shrestha, Bhupal G Shrestha   +5 more
doaj   +1 more source

Karamurskainautomaation A2020- ja IC50-varaosanäyttöjen ohjelmointi DC Europessa [PDF]

, 2010
DC Europe toimittaa A2020- ja IC50 -varaosanäyttöjä ympäri maailmaa kiinteisiin GPkaramurskaimiin, pyöräalustaisiin-Nordwheeler ja tela-alustaisiin-Lokotrack murskausyksikköihin lähes päivittäin.
Niinilammi, Pekka
core  

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Antidiabetic Activity of an Ayurvedic Formulation Chaturmukha Rasa: A Mechanism Based Study

Journal of Pharmacopuncture, 2019
Objectives: The objective of this study was to evaluate antidiabetic activity of Chaturmukha rasa based on streptozotocin induced diabetes model, alpha amylase inhibitory activity, alpha Glucosidase inhibitory activity and inhibition of sucrase ...
Akansha Sharma, Raj K Tiwari, Vikas Sharma, Ravindra K Pandey, Shiv Shnakar Shukla   +4 more
doaj   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source