Results 91 to 100 of about 504,672 (298)

Determination of Polyphenol Compounds in Clinacanthus nutans and Their Potential as Antioxidants

Biotropika: Journal of Tropical Biology
Free radicals can cause oxidative damage if they are produced in excess amounts in the body. To prevent this, the work of endogenous antioxidants needs to be supported by safe and effective exogenous antioxidants.
Nashi Widodo, Salma Wahid Marseti, Yuslinda Annisa, Fairuz Sarah Kamila, Nuraini Rosyadah, Muhaimin Rifa’i   +5 more
doaj   +1 more source

Original Multivalent Gold (III) and Dual Gold(III)-Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents [PDF]

, 2017
Original metallophosphorus dendrimers (generation 3, 48 terminal groups) have been prepared via the complexation of phosphorus dendrimers bearing imino-pyridino end groups with Au(III) or with both Au(III) and Cu(II).
Anne-Marie Caminade, Eligia M. Szewcyk, Elzbieta Pedziwiatr-Werbicka, Jean Pierre Majoral, Maria Bryszewska, Mosto M. Bousmina, Nabil El Brahmi, Regis Laurent, Saïd El Kazzouli, Serge M. Mignani, Sonia Ladeira, Thierry Cresteil   +11 more
core   +3 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Phytochemical screening, antibacterial and cytotoxic activities of Aristolochia philippinensis Warb. leaf extracts

International Journal of Secondary Metabolite
The Aristolochia philippinensis Warb. (Aristolochiaceae) is commonly used in traditional medicine among indigenous people in the Philippines. The leaves of A.
Eddie Mondejar, Vanessa Grace Narvasa
doaj   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE)

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry
The leaves extract of Rourea coccinea was fractionated, following the bioguided method, to give one phenolic compound named 1-caffeoylquinic acid lactone (1-CQL) (1), isolated from this plant for the first time, and the 3-O-β-D-glucopyranoside of ...
BASILE GOUETI , WILLIAM FEUDJOU , BÉNÉDICTA KPADONOU-KPOVIESSI , BARDIEU ATCHADE , SERONDO UWIKUNDA , LÉON AHOUSSI , JOACHIM GBENOU , SALOMÉ KPOVIESSI   +7 more
doaj  

The effect of acetone extract of Moringa peregrina on Trichomonas vaginalis, Candida albicans and macrophage cells in vitro.

مجله علمی دانشگاه علوم پزشکی کردستان, 2018
Background and Aim: Vulvovaginal candidiasis and trichomoniasis account for at least 50 percent of all cases of vaginal infections. The main drugs used to treat these infections have numerous side effects and drug resistance to them is on the rise.
Mina Ebrahimi, Javid Sadraei, Shahla Roudbarmohammadi, Fatemeh Nikoomanesh   +3 more
doaj  

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Cannabigerol Treatment Shows Antiproliferative Activity and Causes Apoptosis of Human Colorectal Cancer Cells

Journal of Pharmacopuncture
Objectives: To determine growth inhibitory and anti-cancer effects of Cannabigerol (CBG) in human colorectal cancer cells.Methods: Anti-proliferative effect of CBG was examined using MTT assay and two colorectal cancer cells (SW480 and LoVo cells).
Ju-Hee Park, Yu-Na Hwang, Han-Heom Na, Do-Yeon Kim, Hyo-Jun Lee, Tae-Hyung Kwon, Jin-Sung Park, Keun-Cheol Kim   +7 more
doaj   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source