Results 71 to 80 of about 504,672 (298)

Chemical Composition and in Vitro Evaluation of the Antioxidant and Antimicrobial Activities of Eucalyptus gillii Essential Oil and Extracts [PDF]

, 2012
In this study, essential oil and various extracts (hexane, petroleum ether, acetone, ethanol, methanol and water) of Eucalyptus gilii were screened for their chemical composition, antimicrobial and antioxidant activities.
Ahmed Lebrihi, Arvouet-Grand, Brooke, Cheng, Damjanovic-Vratnica, Dorsaf Ben Hassine, Florence Mathieu, Folin, François Couderc, Giamakis, Jaimand, Jalloul Bouajila, Manef Abderrabba, Naczk, Pittman, Rahman, Sikkema, Singab, Sonboli, Ultee, Yan Yvon   +20 more
core   +5 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Mitochondrial apoptosis induced by Chamaemelum nobile extract in breast cancer cells [PDF]

, 2016
Chamaemelum nobile (Asteraceae) commonly known as ‹Roman chamomile› is a medicinal plant used for numerous diseases in traditional medicine, although its anticancer activity is unknown.
Amanzadeh, A., Kandelous, H.M., Khuri, V., Rastkari, N., Salimi, M., Salimi, M.   +5 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Anticancer Efficacy of 5-Fluorouracil-Loaded Chitin Nanohydrogel in Enhanced Skin Cancer Therapy

BIO Integration
The pyrimidine analog 5-flurouracil (5-FU) is effective against solid tumors. However, the half-life of intravenously administered 5-FU is less than 20 min, and the compound is quickly eliminated and shows systemic toxicity.
Yuvraj D. Dange, Vijay R. Salunkhe, Sandip M. Honmane, Pradnya S. Marale   +3 more
doaj   +1 more source

Isolation, characterization and antioxidant activity of fibrinogen-like protein-1 from serum and synovial fluid of patients with rheumatoid arthritis [PDF]

The Ukrainian Biochemical Journal
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and oxidative stress. Fibrinogen-like protein-1 (FGL1) has been implicated in immune regulation, but its antioxidant role under inflammatory conditions remains ...
Abdulsattar J. Abdullah, Zahraa M. A. Hamodat   +1 more
doaj   +1 more source

AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KELOR (Moringa oleifera Lam.) DAN BUAH BIT (Beta vulgaris L.) SEBAGAI BAHAN TAMBAHAN MINUMAN SUPLEMEN

Jurnal Kimia Riset, 2020
Minuman suplemen merupakan produk pelengkap kebutuhan zat gizi makanan yang mempunyai nilai gizi dan atau efek fisiologis dalam jumlah terkonsentrasi. Bahan tambahan dalam minuman suplemen dapat diperoleh dari tanaman yang memiliki aktivitas antioksidan.
, Tukiran, Mauren Gita Miranti, Idah Dianawati, fauzia indah sabila   +3 more
doaj   +1 more source