Results 51 to 60 of about 417,281 (310)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Antioxidant Activity of Fungus Comb Extracts Isolated from Indo-Malayan Termite Macrotermes gilvus Hagen (Isoptera: Termitidae)

Indonesian Journal of Chemistry, 2022
Indonesian termites are one of the wealthiest biological resources considering their very high species diversity (300 species) and extensive geographical distribution in the Indonesian mainland.
Yanti Rachmayanti, Dikhi Firmansyah, Reza Ro'isatul Umma, Decsa Medika Hertanto, I Ketut Sudiana, Djoko Santoso, Dodi Nandika, Lina Karlinasari, Arinana Arinana, Irmanida Batubara, Lucia Dhiantika Witasari   +10 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Protective Effects of Trigonella foenum graecum L. Extract Against Cytotoxicity Induced by Cyclophosphamide on Ovarian Cancer (SKOV3) and Normal Cell Lines

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Today, medicinal plants are of great importance in treatment of different cancers. Trigonella foenum graecum L. (fenugreek) is a herbaceous plant with phenolic compounds that has received attention in cytotoxicity studies. The aim
Mohammad Shokrzadeh, Emran Habibi, Niloofar Pourfoladchi, Hamidreza Mohammadi   +3 more
doaj  

Aktivitas antioksidan ekstrak bunga telang (Clitoria ternatea L.) dan aplikasinya dalam sediaan serum

Agrointek
The unhealthy lifestyle of Indonesians can increase the amount of free radicals that have an impact on skin health. Free radicals can be prevented by increasing antioxidants derived from telang flower (Clitoria ternatea L.). The purpose of this study was
Selly Harnesa Putri, Hasyyati Nadhilah, Dian Juliadmi, Asri Widyasanti   +3 more
doaj   +1 more source

Genistein's 50% Inhibitory Concentration (IC50).

, 2013
(A) Cultured Huh7 cells were treated with increasing doses of genistein or DMSO (control), and inoculated with 4×104 P. berghei ANKA sporozoites. Infection was determined 24 hours later by parasite-specific 18S rRNA qRT PCR, and an IC50 of 20 μM was ...
Maria M. Mota (74735), Lígia A. Gonçalves (40141), Margarida Cunha-Rodrigues (65513), Werner Haas (74734), Miguel Prudêncio (74730), Cristina Casalou (74731), Sílvia Portugal (65514), Robert Sauerwein (74733), Dominik Buger (74732)   +8 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

MTX IC50 (uM) prediction with BOSO-BIC model.

, 2022
Using the BOSO-BIC model, prediction of MTX IC50 values in micro molar for cell lines that are not included in the training process: 708 cell lines that are not present in the GDSC database and 6 cell lines part of the GDSC database for experimental ...
Xabier Cendoya (12700321), Xabier Agirre (143264), Felipe Prósper (138706), Francisco J. Planes (6628901), Ángel Rubio (5660173), Edurne San José-Enériz (12239950), Luis V. Valcárcel (12700318)   +6 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Amino Acid Patterns that Determine Antihyperuricemic Activity of Peptides: Identification and Predictive Analysis

Техника и технология пищевых производств
Peptides offer a promising analogue to synthetic drugs in treating hyperuricemia. This article introduces reliable amino acid patterns that cause the inhibitory xanthine oxidase (CSR) activity of peptides.
Anastasia V. Smirnova, Sergey L. Tikhonov   +1 more
doaj   +1 more source