Results 31 to 40 of about 417,281 (310)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
IC50 assays for Compounds A-I.
, 2022 A-I) 48-hour Sybr Green growth inhibition assays were conducted for each of the nine putative ApiAP2 competitor compounds in order to determine IC50 values against asexual P. falciparum. All growth assays were performed in triplicate.
Charisse Flerida A. Pasaje (13949382) +13 more
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Pigment InternationalAn ideal topical depigmenting agent acts quickly, and it selectively targets the melanocytes with appreciable clinical efficacy and tolerability. Traditionally, tyrosinase inhibitors (Tyri) such as kojic acid, hydroquinone and arbutin have been used both
Tarang Goyal +3 more
doaj +1 more source
Variation in IC50 dependent on Fc receptor expression.
, 2022 Variation in half-maximal inhibitory concentrations (IC50) between three stable cell lines (293T-ACE2, 293T-ACE2-FcαR, and 293T-ACE2-FcγRIIA) infected with an MLV viral particle pseudotyped with SARS-CoV-2 S protein and titrated with SARS-CoV-2 plasma or
Sanath Kumar Janaka (8727714) +7 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Biotropika: Journal of Tropical BiologyBiodegradable plastics are increasingly being promoted as environmentally friendly alternatives to conventional plastics. However, under aquatic conditions, their degradation may remain incomplete, leading to the formation of microplastics and leachates ...
Nur Aini Azizah +3 more
doaj +1 more source
Estimated IC50 values for cell proliferation inhibition.
, 2018 Estimated IC50 values for cell proliferation inhibition.
Kevin Woolard (113139) +5 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Majalah Obat TradisionalCancer treatment is known to cause side effects ranging from mild to severe, which can also affect the quality of the patient's health. Natural ingredients are an alternative source of cytotoxic substances with good anticancer activity and minimum side ...
Rezlie Bellatasie +3 more
doaj +1 more source