Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. [PDF]
, 2019 Assaying lipolytic enzymes is extremely challenging because they act on water-insoluble lipid substrates, which are normally components of micelles, vesicles, and cellular membranes.
Armando, Aaron +2 more
core +6 more sources
Jurnal Riset Kimia, 2021 Pacar air (Impatiens balsamina L.) plant belongs to the Balsaminaceae family and is used as an indigenous medicine in Asia for fingernail inflammation, fractures, and rheumatism treatments.
Morina Adfa +4 more
doaj +1 more source
Uji Antioksidan dan Karakterisasi Minyak Atsiri dari Kulit Jeruk Purut (Citrus hystrix D. C)
JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2023 Minyak atsiri banyak digunakan sebagai bahan baku kosmetik, salah satunya minyak atsiri kulit jeruk purut sebagai antioksidan. Berkembangnya pasar minyak atsiri menjadi faktor pendorong pemalsuan karena hasil produksi rendah, tidak adanya standar ...
Fadzil Latifah +2 more
doaj +1 more source
In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]
, 2010 The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg +5 more
core +5 more sources
Different Sites of Alcohol Action in the NMDA Receptor GluN2A and GluN2B Subunits [PDF]
, 2015 The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action.
Allgaier +68 more
core +2 more sources
EC50 and IC50 Measurements of TRPM8 in Lipid Bilayers [PDF]
Biophysical Journal, 2012 Ensemble measurements of ion channel currents, made in the presence of pharmaceutical compounds, enable determination of compound activity and potency in the form of IC50 and EC50 values, and are traditionally performed with Patch Clamp. An alternative platform for ion channel study involves the formation of artificial bilayers from the contact of ...
Salazar, Carl +2 more
openaire +1 more source
Borneo Journal of Pharmacy, 2020 Bidara (Ziziphus spina-christi L.) is a tropical tree originating from Sudan in which it is commonly known as "Nebeq" in Saudi Arabia. It is of a bioactive compound - a flavonoid compound, which is the potential to be used as an antioxidant.
Dwi Bagus Pambudi +2 more
doaj +1 more source
Inhibitors of bacterial and plants urease [PDF]
, 2013 Urease is an important virulence factor for Helicobacter pylori and Proteus mirabilis as well as in environmental transformations of certain nitrogenous compounds.
Macegoniuk, Katarzyna
core +2 more sources
Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma [PDF]
, 2015 Patients with metastatic melanoma bearing V600 mutations in BRAF oncogene clinically benefit from the treatment with BRAF inhibitors alone or in combination with MEK inhibitors.
Ascierto, Paolo Antonio +16 more
core +4 more sources
ICECAP: An Integrated, General-Purpose, Automation-Assisted IC50/EC50 Assay Platform [PDF]
SLAS Technology, 2015 IC50 and EC50 values are commonly used to evaluate drug potency. Mass spectrometry (MS)-centric bioanalytical and biomarker labs are now conducting IC50/EC50 assays, which, if done manually, are tedious and error-prone. Existing bioanalytical sample preparation automation systems cannot meet IC50/EC50 assay throughput demand.A general-purpose ...
Ming, Li +5 more
openaire +2 more sources