Results 11 to 20 of about 417,281 (310)

DFT Based Computational Methodology of IC50 [PDF]

, 2019
A new method derived from the relative toxicity equation termed as RICM, for the computation of IC 50 , is reported here. It is tested for both organic and organometallic compounds as HIV-1 capsid A inhibitors and cancer drugs. Computed results match very well with the experiment.
Arijit, Bag, Arijit Bag (4391890)
openaire   +2 more sources

ACE-inhibitory activity assay: IC50 v1 [PDF]

, 2022
This protocol describes the procedure for the determination of the IC50 in inhibition on angiotensin-I converting enzyme (ACE) activity. ACE is also known as peptidyl dipeptidase A because it removes C-terminal dipeptides from a wide variety of peptide substrates.
Ezequiel R. Coscueta, & Maria Manuela Pintado   +1 more
openaire   +2 more sources

AZD6244 perturbation versus IC50.

, 2021
Linear model fit of AZD6244 IC50 response to perturbations including AZD6244. Points are independent replicates, n = 2. (PDF)
Nils Blüthgen (21491), Clemens Messerschmidt (7337738), Matthias Selbach (317683), Dieter Beule (4752051), Angelika Eggert (24403), Mathurin Dorel (11649108), Tommaso Mari (11649111), Falk Hertwig (11649117), Joern Toedling (180996), Eric Blanc (12755), Michal Nadler-Holly (9160835), Matthias Ziehm (112285), Bertram Klinger (9625424), Anja Sieber (11649114), Johannes H. Schulte (7949249)   +14 more
core   +1 more source

IC50 and gene expression.

, 2021
Top correlation between IC50 and mRNA transcript per million for the 1000 most variable genes (top, adjusted p>0.93) and GO signal transduction genes (bottom, adjusted p>0.94). (PDF)
Nils Blüthgen (21491), Clemens Messerschmidt (7337738), Matthias Selbach (317683), Dieter Beule (4752051), Angelika Eggert (24403), Mathurin Dorel (11649108), Tommaso Mari (11649111), Falk Hertwig (11649117), Joern Toedling (180996), Eric Blanc (12755), Michal Nadler-Holly (9160835), Matthias Ziehm (112285), Bertram Klinger (9625424), Anja Sieber (11649114), Johannes H. Schulte (7949249)   +14 more
core   +1 more source

IC50 and mutations.

, 2021
t-test comparison of the IC50 in mutant (Mut) versus wild type (WT) for RAS/P53 and associated genes with mutation frequency between 30% and 70% in our panel. (PDF)
Nils Blüthgen (21491), Clemens Messerschmidt (7337738), Matthias Selbach (317683), Dieter Beule (4752051), Angelika Eggert (24403), Mathurin Dorel (11649108), Tommaso Mari (11649111), Falk Hertwig (11649117), Joern Toedling (180996), Eric Blanc (12755), Michal Nadler-Holly (9160835), Matthias Ziehm (112285), Bertram Klinger (9625424), Anja Sieber (11649114), Johannes H. Schulte (7949249)   +14 more
core   +1 more source

Aktivitas Antioksidan Ekstrak Air Kombinasi Kulit Pisang Kepok (Musa paradisiaca L.) dan Nanas (Ananas comosus L.) dengan Metode DPPH dan FRAP

Indonesian Journal of Pharmaceutical Education, 2023
Banana kepok (Musa paradisiaca L.) and pineapple (Ananas comosus L.) are types of fruit that are widely consumed by the community. However, the skin is only disposed of as waste, where the waste of the fruit skin reaches 30% of the whole fruit.
Vivian Fu, Pratiwi Apridamayanti, Sri Luliana   +2 more
doaj   +1 more source

In vitro antimalarial activity of some organotin(IV)2-nitrobenzoate compounds against Plasmodium falciparum

Macedonian Journal of Chemistry and Chemical Engineering, 2018
Antimalarial activity study of organotin(IV) derivatives with nitrobenzoic acid derivatives used as ligands has been performed. The targeted compounds were prepared from their organotin(IV) chlorides via dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide,
Sutopo Hadi, Noviany Noviany, Mita Rilyanti   +2 more
doaj   +1 more source

Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide—a model for the active-site cysteine of protein tyrosine phosphatase 1B [PDF]

, 2011
The organometallic anticancer complex [(η6-p-cymene)Ru(en)Cl]PF6 (1, en = ethylenediamine) readily reacts with thiols and forms stable sulfenate/sulfinate adducts which may be important for its biological activity. Protein tyrosine phosphatase 1B (PTP1B),
Hu, Wenbing, Han, Yumiao, Sadler, P. J., Kui Wu, Lü, Shuang, Luo, Qun, Wu, Kui, Qun Luo, Fuyi Wang, Wenbing Hu, Shuang Lü, Hao, Xiang, Li, Xianchan, Xiang Hao, Peter J. Sadler, Yumiao Han, Wang, Fuyi, Xianchan Li   +17 more
core   +1 more source

POLYPHENOLIC WEALTHY MORINGA LEAVES EXTRACTS AS ANTICOXSACKIE B VIRUSES (COX-BV) [PDF]

Arab Universities Journal of Agricultural Sciences, 2019
The antiviral role of Moringaoleifera leaves extracts ((chloroform (CL), Ethyl acetate (E.A), methanol 80% (M) and n.butanol (n.b) to control Coxsackie B (COX-BV) viral infection was monitored in vitro compared with human interferon alpha (IFNᾰ2a) in ...
Naglaa Saif, B. Othman, A. Mohamed, Kh. El-Dougdoug   +3 more
doaj   +1 more source

Evolution of PIKK family kinase inhibitors: A new age cancer therapeutics

Frontiers in Bioscience-Landmark, 2020
Phosphatidylinositol-3 kinase-related kinases (PIKKs) belong to a family of atypical serine/threonine kinases in humans. They actively participate in a diverse set of cellular functions such as meiotic, V(D)J recombination, chromosome maintenance, DNA ...
Althaf Shaik, Sivapriya Kirubakaran
doaj   +1 more source