Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties [PDF]
, 2019 Purified phlorotannin extracts from four brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira usneoides (Linnaeus) M.
Andrade, Paula +6 more
core +1 more source
Preliminary characterization of a Moroccan honey with a predominance of Bupleurum spinosum pollen [PDF]
, 2017 Honey with Bupleurum spinosum (zandaz) as a main pollen source has not been the subject of previous detailed study. Therefore, twelve Moroccan samples of this honey were subjected to melissopalynological, physicochemical and microbiological quality ...
Badiâa Lyoussi +17 more
core +3 more sources
Performance Comparisons of AlexNet and GoogLeNet in Cell Growth Inhibition IC50 Prediction [PDF]
International Journal of Molecular Sciences, 2021 Drug responses in cancer are diverse due to heterogenous genomic profiles. Drug responsiveness prediction is important in clinical response to specific cancer treatments. Recently, multi-class drug responsiveness models based on deep learning (DL) models using molecular fingerprints and mutation statuses have emerged.
Yeeun Lee, Seungyoon Nam
openaire +2 more sources
Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms [PDF]
, 2018 The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Grange, Dorothy K. +7 more
core +2 more sources
A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins [PDF]
, 2017 Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation.
Cavalcanti-Adam, Elisabetta Ada +12 more
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Efavirenz concentrations in CSF exceed IC50 for wild-type HIV [PDF]
Journal of Antimicrobial Chemotherapy, 2010 HIV-associated neurocognitive disorders remain common despite use of potent antiretroviral therapy (ART). Ongoing viral replication due to poor distribution of antivirals into the CNS may increase risk for HIV-associated neurocognitive disorders. This study's objective was to determine penetration of a commonly prescribed antiretroviral drug, efavirenz,
B. M. Best +52 more
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Insisiva Dental Journal, 2012 Kemangi (Ocimum basilicum L.) merupakan tanaman yang sering digunakan untuk obat tradisional. Kandungan eugenol dalam minyak atsiri daun kemangi memiliki efek antibakteri terhadap bakteri Gram positif.
Like Rosita Dwi Susanto +2 more
doaj +1 more source
Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]
, 2016 This Letter was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Scottish Universities Life Sciences Alliance (SULSA) in 2011Peer ...
Abdelrahman, Mostafa Hamed +4 more
core +1 more source
Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]
, 2020 Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M +8 more
core +3 more sources
Journal of Halal Product and Research, 2020 Unhealthy lifestyles and air pollution cause the number of free radicals in the body to increase. To protect the body from free radicals, there are antioxidant compounds as an antidote and stabilize free radicals. One of the Indonesian plants that can be
Muhammad Ainul Yahya +1 more
doaj +1 more source