Results 21 to 30 of about 417,281 (310)

EC50 and IC50 Measurements of TRPM8 in Lipid Bilayers [PDF]

Biophysical Journal, 2012
Ensemble measurements of ion channel currents, made in the presence of pharmaceutical compounds, enable determination of compound activity and potency in the form of IC50 and EC50 values, and are traditionally performed with Patch Clamp. An alternative platform for ion channel study involves the formation of artificial bilayers from the contact of ...
Salazar, Carl, El-Arabi, Ahmad M., Schmidt, Jacob J.   +2 more
openaire   +1 more source

Performance Comparisons of AlexNet and GoogLeNet in Cell Growth Inhibition IC50 Prediction [PDF]

International Journal of Molecular Sciences, 2021
Drug responses in cancer are diverse due to heterogenous genomic profiles. Drug responsiveness prediction is important in clinical response to specific cancer treatments. Recently, multi-class drug responsiveness models based on deep learning (DL) models using molecular fingerprints and mutation statuses have emerged.
Yeeun Lee, Seungyoon Nam
openaire   +2 more sources

Comparison of destabilizing activities of a well-known αβ-fibril destabilizer rifampicin with methylene blue for its usage in Alzheimer’s disease treatment [PDF]

, 2013
The aim of this experiment was to determine whether methylene blue has a destabilizing effect on αβ-fibrils or not for the usage in Alzheimer’s disease treatment.
Dursun, Merve
core   +1 more source

Efek Minyak Atsiri Daun Kemangi (Ocimum Basilicum L.) Sebagai Agen Penghambat Pembentukan Biofilm Streptococcus Mutans

Insisiva Dental Journal, 2012
Kemangi (Ocimum basilicum L.) merupakan tanaman yang sering digunakan untuk obat tradisional. Kandungan eugenol dalam minyak atsiri daun kemangi memiliki efek antibakteri terhadap bakteri Gram positif.
Like Rosita Dwi Susanto, Archadian Nuryanti, Ivan Arie Wahyudi   +2 more
doaj   +1 more source

IC50 values of antibodies against escape mutant HCVcc.

, 2022
IC50 values of antibodies against escape mutant HCVcc.
Noriko Nakamura (670459), Noriyuki Watanabe (434683), Hiroshi Yokokawa (13844621), Hideki Aizaki (139942), Hideki Narumi (13844630), Kazuaki Chayama (128675), Tomoko Date (249626), Yuji Teraoka (4348378), Michio Imamura (128656), Tomokatsu Iwamura (13844627), Takaji Wakita (109321), Midori Shinohara (13844624)   +11 more
core   +1 more source

Antioxidant activity ethanol extract of gotu kola (Centella asiatica (L.) Urban) with DPPH method (2,2-Diphenyl-1-Pikrilhidrazil)

Journal of Halal Product and Research, 2020
Unhealthy lifestyles and air pollution cause the number of free radicals in the body to increase. To protect the body from free radicals, there are antioxidant compounds as an antidote and stabilize free radicals. One of the Indonesian plants that can be
Muhammad Ainul Yahya, Iif Hanifa Nurrosyidah   +1 more
doaj   +1 more source

Potensi Daun Pacar Air (Impatiens balsamina L.) dalam Menghambat Pertumbuhan Jamur Rhizopus oryzae L.

Jurnal Riset Kimia, 2021
Pacar air (Impatiens balsamina L.) plant belongs to the Balsaminaceae family and is used as an indigenous medicine in Asia for fingernail inflammation, fractures, and rheumatism treatments.
Morina Adfa, Munifilia Ekasari, Avidlyandi Avidlyandi, Rochmah Supriati, Salprima Yudha S.   +4 more
doaj   +1 more source

Efavirenz concentrations in CSF exceed IC50 for wild-type HIV [PDF]

Journal of Antimicrobial Chemotherapy, 2010
HIV-associated neurocognitive disorders remain common despite use of potent antiretroviral therapy (ART). Ongoing viral replication due to poor distribution of antivirals into the CNS may increase risk for HIV-associated neurocognitive disorders. This study's objective was to determine penetration of a commonly prescribed antiretroviral drug, efavirenz,
B. M. Best, P. P. Koopmans, S. L. Letendre, E. V. Capparelli, S. S. Rossi, D. B. Clifford, A. C. Collier, B. B. Gelman, G. Mbeo, J. A. McCutchan, D. M. Simpson, R. Haubrich, R. Ellis, I. Grant, I. Grant, J. A. McCutchan, R. J. Ellis, T. D. Marcotte, D. Franklin, R. J. Ellis, J. A. McCutchan, T. Alexander, S. Letendre, E. Capparelli, R. K. Heaton, J. H. Atkinson, S. P. Woods, M. Dawson, J. K. Wong, C. Fennema-Notestine, M. J. Taylor, R. Theilmann, A. C. Gamst, C. Cushman, I. Abramson, F. Vaida, T. D. Marcotte, R. von Jaeger, J. McArthur, M. Smith, S. Morgello, D. Simpson, L. Mintz, J. A. McCutchan, W. Toperoff, A. Collier, C. Marra, T. Jones, B. Gelman, E. Head, D. Clifford, M. Al-Lozi, M. Teshome   +52 more
openaire   +2 more sources

Test on the Antioxidant Activities of Methanol Extract of Bidara Leaves (Ziziphus spina-christi L.) using the DPPH Radical Immersion Method

Borneo Journal of Pharmacy, 2020
Bidara (Ziziphus spina-christi L.) is a tropical tree originating from Sudan in which it is commonly known as "Nebeq" in Saudi Arabia. It is of a bioactive compound - a flavonoid compound, which is the potential to be used as an antioxidant.
Dwi Bagus Pambudi, Nuniek Nizmah Fajriyah, Vidiah Rizka Shalekhah   +2 more
doaj   +1 more source

Uji Antioksidan dan Karakterisasi Minyak Atsiri dari Kulit Jeruk Purut (Citrus hystrix D. C)

JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2023
Minyak atsiri banyak digunakan sebagai bahan baku kosmetik, salah satunya minyak atsiri kulit jeruk purut sebagai antioksidan. Berkembangnya pasar minyak atsiri menjadi faktor pendorong pemalsuan karena hasil produksi rendah, tidak adanya standar ...
Fadzil Latifah, Hudan Taufiq, Nur Maulida Fitriyana   +2 more
doaj   +1 more source