Results 41 to 50 of about 504,672 (298)
The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]
, 2011 Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGF beta and BMP signals, have been employed extensively to assess their physiological roles in cells and organisms. While all of these inhibitors have been
Sapkota, Gopal P. +2 more
core +3 more sources
Sains Natural, 2023 Tampoi (Baccaurea macrocarpa (Miq.) Mull.Arg) is a member of the genus Baccaurea which is distributed mainly in the regions of Borneo and Sumatra. The use of tampoi can be done by exploring the potential of tampoi plants as medicinal plants. The research
Sujarwati +3 more
doaj +1 more source
Cadmium IC50 determinations on Chlorella vulgaris involving different parameters
Ecotoxicology and Environmental Safety, 1980 Abstract The ecotoxicity of cadmium nitrate has been tested, at the basic trophic level, on a chlorophycea alga, Chlorella vulgaris. Several parameters of growth, under strictly defined conditions, have been selected: opacimetry at 665 nm, cell count biomass volume estimation (Coulter counter), and ATP and chlorophyll levels.
R, Truhaut, J F, Ferard, J M, Jouany
openaire +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Separation and Purification of ACE Inhibitory Peptide from Jellyfish by Macroporous Resin
Shipin gongye ke-ji, 2022 In this paper, the separation and purification of jellyfish polypeptide with Angiotensin-I converting enzyme (ACE) inhibitory activity by macroporous adsorption resin was studied from the perspective of molecular polarity.
Tingting CUI +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Pigment InternationalAn ideal topical depigmenting agent acts quickly, and it selectively targets the melanocytes with appreciable clinical efficacy and tolerability. Traditionally, tyrosinase inhibitors (Tyri) such as kojic acid, hydroquinone and arbutin have been used both
Tarang Goyal +3 more
doaj +1 more source
Arylmethylamino steroids as antiparasitic agents [PDF]
, 2017 In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive ...
Becker, Katja +19 more
core +3 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Biotropika: Journal of Tropical BiologyBiodegradable plastics are increasingly being promoted as environmentally friendly alternatives to conventional plastics. However, under aquatic conditions, their degradation may remain incomplete, leading to the formation of microplastics and leachates ...
Nur Aini Azizah +3 more
doaj +1 more source