Results 41 to 50 of about 288,159 (307)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Do Biodegradable Microplastics Threaten Chlorella spp.? First Study in Indonesia Using Leachate Exposure

Biotropika: Journal of Tropical Biology
Biodegradable plastics are increasingly being promoted as environmentally friendly alternatives to conventional plastics. However, under aquatic conditions, their degradation may remain incomplete, leading to the formation of microplastics and leachates ...
Nur Aini Azizah, Dwi Hindarti, Endang Yuli Herawati, Dicky Willy Nainggolan   +3 more
doaj   +1 more source

Antioxidant Activity of Fungus Comb Extracts Isolated from Indo-Malayan Termite Macrotermes gilvus Hagen (Isoptera: Termitidae)

Indonesian Journal of Chemistry, 2022
Indonesian termites are one of the wealthiest biological resources considering their very high species diversity (300 species) and extensive geographical distribution in the Indonesian mainland.
Yanti Rachmayanti, Dikhi Firmansyah, Reza Ro'isatul Umma, Decsa Medika Hertanto, I Ketut Sudiana, Djoko Santoso, Dodi Nandika, Lina Karlinasari, Arinana Arinana, Irmanida Batubara, Lucia Dhiantika Witasari   +10 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cytotoxic Activity of Ethanol Extract of Piper aduncum L. on T47D Breast Cancer Cell Line using the MTT Method

Majalah Obat Tradisional
Cancer treatment is known to cause side effects ranging from mild to severe, which can also affect the quality of the patient's health. Natural ingredients are an alternative source of cytotoxic substances with good anticancer activity and minimum side ...
Rezlie Bellatasie, Sri Oktavia, Hanaya Fathiha Rakhmil, Hendri Satria Kamal Uyun   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

DFT Based Computational Methodology of IC50 [PDF]

, 2019
A new method derived from the relative toxicity equation termed as RICM, for the computation of IC50, is reported here. It is tested for both organic and organometallic compounds as HIV-1 capsid A inhibitors and cancer drugs. Computed results match very well with the experiment.
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Aktivitas antioksidan ekstrak bunga telang (Clitoria ternatea L.) dan aplikasinya dalam sediaan serum

Agrointek
The unhealthy lifestyle of Indonesians can increase the amount of free radicals that have an impact on skin health. Free radicals can be prevented by increasing antioxidants derived from telang flower (Clitoria ternatea L.). The purpose of this study was
Selly Harnesa Putri, Hasyyati Nadhilah, Dian Juliadmi, Asri Widyasanti   +3 more
doaj   +1 more source

Table S1: IC50 (nM) for M cells deleted PSMC subunits treated with BTZ from CRISPR Genome-Wide Screening Identifies Dependence on the Proteasome Subunit PSMC6 for Bortezomib Sensitivity in Multiple Myeloma [PDF]

, 2023
Chang‐Xin Shi, K. Martin Kortüm, Yuan Xiao Zhu, Laura A. Bruins, Patrick Jedlowski, Patrick G. Votruba, Moulun Luo, Robert A. Stewart, Jonathan M. Ahmann, Esteban Braggio, A. Keith Stewart   +10 more
openalex   +1 more source