Results 81 to 90 of about 288,159 (307)

The Cytoxic Effects Of Forest Honey (Apis dorsata) On T47D Breast Cancer Cells

Magna Medika
Background: In 2018, an estimated 2 million people had breast cancer. Forest honey (Apis dorsata) can have antioxidant activity due to the presence of flavonoid saponin, alkaloid, and tannin compound, therefore can be used as anticancer through the ...
Malik Hisyam Adnan, Maya Dian Rakhmawatie, Yanuarita Tursinawati   +2 more
doaj   +1 more source

Antidiabetic Activity of an Ayurvedic Formulation Chaturmukha Rasa: A Mechanism Based Study

Journal of Pharmacopuncture, 2019
Objectives: The objective of this study was to evaluate antidiabetic activity of Chaturmukha rasa based on streptozotocin induced diabetes model, alpha amylase inhibitory activity, alpha Glucosidase inhibitory activity and inhibition of sucrase ...
Akansha Sharma, Raj K Tiwari, Vikas Sharma, Ravindra K Pandey, Shiv Shnakar Shukla   +4 more
doaj   +1 more source

CURCUMIN HAS LOWER IC50 VALUES AGAINST A549 LUNG CANCER CELLS [PDF]

, 2023
Sedat Kaçar, Özlem Tomsuk, Varol Şahıntürk   +2 more
openalex   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Study of Phytochemical, Antioxidant and Antimicrobial Activity of Artocarpus heterophyllus

Nepal Journal of Biotechnology, 2016
In today’s world, search for natural medicines is increasing as a result of drug resistance of pathogens and also due to negative consequences of antibiotic.
Nita Thapa, Pratiksha Thapa, Jay Bhandari, Prasodhan Niraula, Nikita Shrestha, Bhupal G Shrestha   +5 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Synthesis of Metal Oxide Nano Particles by Sol-Gel Method and Investigation of its Biomedical Applications [PDF]

Nanochemistry Research
In this investigation, CuO NPs, Cu-MnNCs, and Cu-Co NCs were synthesized by the sol gel method in the presence of the stabilizing agent polyvinyl alcohol (PVA).
Hajira Tahir, Muhammad Saad, Mahreen Latif, S Hyder, Rameez Ahmed   +4 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Effect of Trisindolina-5 Compound on Cancer Stem Cell (CSC) Proliferation in-Vitro [PDF]

BIO Web of Conferences
Cancer stem cells (CSCs) are a subset of cancer cells that have the abilities of normal stem cells. CSCs are cancer cell pioneers with self-renewal abilities that can cause CSCs to differentiate into several cancer cells.
Salispriaji Sholeh, Nurhayati Awik Puji Dyah, Santoso Mardi, Wati First Ambar   +3 more
doaj   +1 more source