Results 91 to 100 of about 7,149 (225)

Animal Models and Treatment of Pulmonary Fibrosis: Pharmacogenetic and Nonpharmacogenetic

open access: yesInternational Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Pulmonary fibrosis is a significant lung injury caused by multiple factors that profoundly affect the human quality of life. Currently, various animal models are used to understand the aetiology of pulmonary fibrosis and develop treatments. However, only pharmacogenetic models of pulmonary fibrosis have been discussed, and there have been no reviews of
Xingyu Fang   +7 more
wiley   +1 more source

Icariin ameliorates the cognitive function in an epilepsy neonatal rat model by blocking the GluR2/ERK I/II pathway

open access: yesFolia Neuropathologica, 2020
The present study was performed to evaluate the protective effects of icariin on cognitive function in a hypoxia-induced neonatal epilepsy rat model.
Ying Guo, Yuxiang Cai, Xiaoge Zhang
doaj   +1 more source

EFFICACY AND MECHANISMS OF MEDICINAL PLANTS AS IMMUNOTHERAPY IN TREATMENT OF ALLERGIC RHINITIS: A SYSTEMATIC REVIEW [PDF]

open access: yes, 2017
Allergic rhinitis is a common disease of immune system that negatively affects general health, quality of life, and social relationships. In the recent years, many studies have been conducted to discover novel treatments for this disease particularly ...
Asadi-Samani, Majid.   +4 more
core  

Icariin Alleviates Bleomycin‐Induced Idiopathic Pulmonary Fibrosis in Mice by Modulating the Gut–Lung Axis and Serum Metabolism

open access: yesInternational Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of uncertain etiology with few specific and effective therapeutic agents approved for its treatment. We examined the underlying processes and the impact of icariin (ICA) on a bleomycin‐induced pulmonary fibrosis model.
Ting Zhang   +5 more
wiley   +1 more source

Icariin, an Anti-atherosclerotic Drug from Chinese Medicinal Herb Horny Goat Weed

open access: yesFrontiers in Pharmacology, 2017
Icariin is a major bioactive pharmaceutical constituent isolated from Chinese medicine Horny Goat Weed (Ying Yang Huo) with potent cardiovascular protective functions.
Jian Fang, Yongjun Zhang
doaj   +1 more source

Resveratrol Demonstrates Antimicrobial Effects Against Propionibacterium acnes In Vitro [PDF]

open access: yes, 2014
IntroductionResveratrol (3,5,4'-trihydroxystilbene) is an antioxidant that has multiple biologic effects including antimicrobial properties. Acne vulgaris is a disease of the pilosebaceous unit, characterized by an inflammatory host immune response to ...
Emma J. M. Taylor   +3 more
core   +2 more sources

Modified Guizhi Plus Huangqi Decoction Improves Antiphospholipase A2 Receptor Antibody–Induced Podocyte Injury Through Modulating Autophagy‐Related Markers via AMPK/mTOR Pathway

open access: yesJournal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) is a primary cause of nephrotic syndrome in adults. Modified Guizhi plus Huangqi decoction (MGPHD) has been clinically effective for PLA2R MN. This basic study was designed to investigate the efficacy and mechanisms of MGPHD in treating PLA2R MN.
Manxia Huang   +9 more
wiley   +1 more source

Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5.

open access: yesPLoS ONE, 2019
The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases.
Yasmin Chau   +3 more
doaj   +1 more source

Local administration of icariin contributes to peripheral nerve regeneration and functional recovery

open access: yesNeural Regeneration Research, 2015
Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component ...
Bo Chen   +9 more
doaj   +1 more source

New‐Onset Psychosis in a Person with Parkinson's Disease after “Horny Goat Weed” Use

open access: yes
Movement Disorders Clinical Practice, Volume 13, Issue 2, Page 541-543, February 2026.
Juan R. Deliz   +3 more
wiley   +1 more source

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