Results 61 to 70 of about 260,636 (325)
, 2011 Ultrathin carbon nanomembranes (CNM) comprising crosslinked biphenyl precursors have been tested as support films for energy-filtered transmission electron microscopy (EFTEM) of biological specimens.
Beyer, André +7 more
core +1 more source
Theoretical Spectra of Terrestrial Exoplanet Surfaces [PDF]
, 2012 We investigate spectra of airless rocky exoplanets with a theoretical framework that self-consistently treats reflection and thermal emission. We find that a silicate surface on an exoplanet is spectroscopically detectable via prominent Si-O features in ...
Batalha +28 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Crystalline hydrogen bonding of water molecules confined in a metal-organic framework
Communications Chemistry, 2022 Determining the spatial ordering and hydrogen bonding dynamics of confined water molecules within nanopores remains challenging. Here, Raman spectroscopy and crystallographic studies show ice-like spatial ordering of unbound water molecules within the ...
Jinhee Bae +3 more
doaj +1 more source
Photochemistry of the PAH pyrene in water ice: the case for ion-mediated solid-state astrochemistry
, 2009 Context. Icy dust grains play an important role in the formation of complex inter- and circumstellar molecules. Observational studies show that polycyclic aromatic hydrocarbons (PAHs) are abundantly present in the ISM in the gas phase.
A. Bakker +48 more
core +1 more source
Rotationally resolved spectroscopy of (20000) Varuna in the near-infrared [PDF]
, 2014 Models of the escape and retention of volatiles by minor icy objects exclude any presence of volatile ices on the surface of TNOs smaller than ~1000km in diameter at the typical temperature in this region of the solar system, whereas the same models show
Emery, J. P. +4 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Frontiers in Earth Science, 2019 Impurities in polar ice cores have been studied so far mainly for the purpose of reconstructions of past atmospheric aerosol concentrations. However, impurities also critically influence physical properties of the ice matrix itself.
Jan Eichler +14 more
doaj +1 more source