Results 101 to 110 of about 543,737 (387)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Conservation Letters, 2020 Beef production is a major driver of biodiversity loss and greenhouse gas emissions globally, and multiple studies recommend reducing beef production and consumption.
Matthew J. Selinske +5 more
doaj +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2023 Maribavir was approved by the US Food and Drug Administration for the treatment of patients aged ≥12 years and weighing ≥35 kg with posttransplant cytomegalovirus infection/disease refractory (with/without resistance) to valganciclovir, ganciclovir ...
Kefeng Sun +3 more
doaj +1 more source
Children's interactions with interactive toy technology [PDF]
, 2003 Digital toys offer the opportunity to explore software scaffolding through tangible interfaces that are not bound to the desktop computer. This paper describes the empirical work completed by the CACHET (Computers and Children's Electronic Toys) project ...
Airey, S. +3 more
core +2 more sources
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Infectious Diseases and TherapyIntroduction The coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare systems globally. The lack of quality guidelines on the management of COVID-19 in rheumatologic disease, renal disease, hematological malignancy,
Jaya Paranilam +5 more
doaj +1 more source
Progress in orthodontics, 2019 The aim of this trial was to comparatively evaluate Icon® resin infiltration and Clinpro™ XT varnish in restoring aesthetics of white spot lesions (WSLs) present post-orthodontic treatment. Two hundred forty WSLs were detected in 193 teeth of 12 patients.
Annapurna Kannan, S. Padmanabhan
semanticscholar +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Journal of Patient-Reported Outcomes, 2021 Objective Despite the development of new biologic therapies, methotrexate (MTX) remains the preferred initial disease-modifying anti-rheumatic drug to treat rheumatoid arthritis (RA). Adherence to disease-modifying anti-rheumatic drugs is suspected to be
Jeffrey R. Curtis +7 more
doaj +1 more source
The upper-atmosphere extension of the ICON general circulation model (version: Ua-icon-1.0) [PDF]
, 2019 How the upper-atmosphere branch of the circulation contributes to and interacts with the circulation of the middle and lower atmosphere is a research area with many open questions.
Baldauf, M. +5 more
core +2 more sources