Results 71 to 80 of about 448,633 (304)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Assessment of the content validity of the Oswestry Disability Index (ODI) in patients with Degenerative Disc Disease (DDD): a qualitative study

BMC Musculoskeletal Disorders
Background Degenerative disc disease (DDD) is a common disorder that can lead to chronic lower back pain (CLBP). The Oswestry Disability Index (ODI) is a well-established instrument for diseases of the lumbar spine and lower back pain (LBP), covering ...
John H. Powers, Rachel Ballinger, Andrea De Palma, Marie de la Cruz, Kellee Howard   +4 more
doaj   +1 more source

Development of the pediatric daily ulcerative colitis signs and symptoms scale (DUCS): qualitative research findings

BMC Research Notes, 2017
Background The purpose of this study is to develop patient-reported (PRO) and observer-reported (ObsRO) outcome measures of ulcerative colitis (UC) signs/symptoms in children aged 5–17 with mild/moderate UC.
Emuella Flood, Debra G. Silberg, Beverly Romero, Kathleen Beusterien, M. Haim Erder, Carmen Cuffari   +5 more
doaj   +1 more source

Comparative Field Evaluation of Combinations of Long-Lasting Insecticide Treated Nets and Indoor Residual Spraying, Relative to Either Method Alone, for Malaria Prevention in an Area where the main Vector is Anopheles Arabiensis. [PDF]

, 2013
Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are commonly used together in the same households to improve malaria control despite inconsistent evidence on whether such combinations actually offer better protection than nets ...
A Bhattarai, A Cohuet, A Ogbonna, A Smith, Alex J Ntamatungiro, AM Eijk, AM Noor, AN Clements, C Drakeley, C Ngufor, CF Curtis, D Chandramohan, Deo R Kavishe, Edgar Mbeyela, Elizabeth Turner, FO Okumu, FO Okumu, FO Okumu, FO Okumu, FO Okumu, FO Okumu, Fredros O Okumu, G Fegan, G MacDonald, GF Killeen, Godfrey Lingamba, H Ranson, H Reyburn, HM Ferguson, I Kleinschmidt, J Beier, J Beier, J Kitau, JA Scott, Jason Moore, JM Mwangangi, JP Grieco, JT Griffin, KI Barnes, KI Barnes, L Yakob, Lena M Lorenz, LF Tseng, LL Koekemoer, M Akogbeto, M Over, MI Msellem, Michael G Kenward, MJ Hamel, ML Mabaso, MN Bayoh, MOH-Zambia, N Chitnis, NJ Govella, PM Nyarango, R Carter, R Development Core Team, RA Khatib, RJ Kent, RL Kouznetsov, S Abdulla, Sarah J Moore, SB Ogoma, SE Clarke, The malERA Consultative Group on Vector Control, TL Russell, TL Russell, V Corbel, W Takken, WA Hawley, WA Hawley, WHO, WHO, WHO, WHO, WHO, WHO, YA Derua   +77 more
core   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Faktor Pemanfaatan Imunisasi Inactivated Polio Vaccine (IPV)

Jurnal Kesehatan, 2020
The low utilization of IPV immunization services in Palembang in 2017 was 66,7% while the national target was 95%. The purpose of this study was to determine the factors associated with the utilization of IPV immunization services in Palembang. The study
Icon Harizon, Misnaniarti Misnaniarti, Haerawati Idris   +2 more
doaj   +1 more source

[sound icon], March 17, 2014 [PDF]

, 2014
This is the concert program of the [sound icon] performance on Monday, March 17, 2014 at 8:00 p.m., at the Boston University Concert Hall, 855 Commonwealth Avenue, Boston, Massachusetts.
School of Music, Boston University
core