Results 81 to 90 of about 543,737 (387)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

COVID-19 Vaccination Recommendations for Immunocompromised Patient Populations: Delphi Panel and Consensus Statement Generation in the United States

Infectious Diseases and Therapy
Introduction The United States Advisory Committee on Immunization Practices (ACIP) and the Centers for Disease Control (CDC) recommend COVID-19 vaccines for all immunocompromised individuals.
Kira Zhi Hua Lai, Stuart Greenstein, Rajesh Govindasamy, Jaya Paranilam, Joseph Brown, Samantha Kimball-Carroll   +5 more
doaj   +1 more source

Comparative Field Evaluation of Combinations of Long-Lasting Insecticide Treated Nets and Indoor Residual Spraying, Relative to Either Method Alone, for Malaria Prevention in an Area where the main Vector is Anopheles Arabiensis. [PDF]

, 2013
Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are commonly used together in the same households to improve malaria control despite inconsistent evidence on whether such combinations actually offer better protection than nets ...
A Bhattarai, A Cohuet, A Ogbonna, A Smith, Alex J Ntamatungiro, AM Eijk, AM Noor, AN Clements, C Drakeley, C Ngufor, CF Curtis, D Chandramohan, Deo R Kavishe, Edgar Mbeyela, Elizabeth Turner, FO Okumu, FO Okumu, FO Okumu, FO Okumu, FO Okumu, FO Okumu, Fredros O Okumu, G Fegan, G MacDonald, GF Killeen, Godfrey Lingamba, H Ranson, H Reyburn, HM Ferguson, I Kleinschmidt, J Beier, J Beier, J Kitau, JA Scott, Jason Moore, JM Mwangangi, JP Grieco, JT Griffin, KI Barnes, KI Barnes, L Yakob, Lena M Lorenz, LF Tseng, LL Koekemoer, M Akogbeto, M Over, MI Msellem, Michael G Kenward, MJ Hamel, ML Mabaso, MN Bayoh, MOH-Zambia, N Chitnis, NJ Govella, PM Nyarango, R Carter, R Development Core Team, RA Khatib, RJ Kent, RL Kouznetsov, S Abdulla, Sarah J Moore, SB Ogoma, SE Clarke, The malERA Consultative Group on Vector Control, TL Russell, TL Russell, V Corbel, W Takken, WA Hawley, WA Hawley, WHO, WHO, WHO, WHO, WHO, WHO, YA Derua   +77 more
core   +3 more sources

IDA4D: Ionospheric Data Assimilation for the ICON Mission

Space Science Reviews, 2020
The Ionospheric Connection Explorer (ICON) mission makes measurements in near-Earth space that provide knowledge of the state of the ionosphere. From the vantage of 575 km altitude in a circular, 27° inclination orbit, it retrieves altitude profiles of ...
G. Bust, T. Immel
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Illustration of patient-reported outcome challenges and solutions in rare diseases: a systematic review in Cushing’s syndrome

Orphanet Journal of Rare Diseases, 2018
Rare diseases are often not fully understood and efforts put in investigating it from patient perspective are usually met with challenges. We performed a systematic literature review (SLR) for the last 20 years in Cushing’s Syndrome (CS) to illustrate ...
Naomi Knoble, Gabrielle Nayroles, Cherry Cheng, Benoit Arnould   +3 more
doaj   +1 more source

Experiences of children and adolescents living with achondroplasia and their caregivers

Molecular Genetics & Genomic Medicine, 2022
Background Achondroplasia, caused by a pathogenic variant in the fibroblast growth factor receptor 3 gene (FGFR3), leads to significant multisystem complications across the lifespan that may affect the health‐related quality of life (HRQoL) of ...
Renée Shediac, Olga Moshkovich, Heather Gerould, Rachel Ballinger, Agnes Williams, M. Alex Bellenger, Jennifer Quinn, Julie Hoover‐Fong, Klaus Mohnike, Ravi Savarirayan, Dominique Kelly   +10 more
doaj   +1 more source

Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

Intensive Care Medicine, 2018
PurposeTo evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time.MethodsWe reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay ...
J. Vincent, J. Lefrant, K. Kotfis, R. Nanchal, I. Martín-Loeches, X. Wittebole, S. Sakka, P. Pickkers, R. Moreno, Y. Sakr   +9 more
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Development of the pediatric daily ulcerative colitis signs and symptoms scale (DUCS): qualitative research findings

BMC Research Notes, 2017
Background The purpose of this study is to develop patient-reported (PRO) and observer-reported (ObsRO) outcome measures of ulcerative colitis (UC) signs/symptoms in children aged 5–17 with mild/moderate UC.
Emuella Flood, Debra G. Silberg, Beverly Romero, Kathleen Beusterien, M. Haim Erder, Carmen Cuffari   +5 more
doaj   +1 more source