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Evaluation of the antimalarial activity of SAM13-2HCl with morpholine amide (SKM13 derivative) against antimalarial drug-resistant Plasmodium falciparum and Plasmodium berghei infected ICR mice. [PDF]
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Teratogenicity of Thujaplicin in ICR Mice
Food and Chemical Toxicology, 1999Beta-thujaplicin (TP) was studied by in vitro and in vivo tests for teratogenicity using ICR mice. In the in vitro study, TP (0, 3.125, 6.25, 12.5 microg/ml medium) dissolved in dimethyl sulfoxide (DMSO) was administered to cultured embryos on 9 day of gestation.
A, Ogata +6 more
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Teratogenicity of thiabendazole in ICR mice
Food and Chemical Toxicology, 1984Thiabendazole (TBZ) was tested for teratogenicity using Jcl:ICR mice. TBZ suspended in olive oil was given orally to pregnant mice at different stages of organogenesis. All foetuses were removed from the uterus on day 18 of gestation, and were examined for external and skeletal anomalies.
A, Ogata, H, Ando, Y, Kubo, K, Hiraga
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Carcinogenicity of Halothane in Swiss/ICR Mice
Survey of Anesthesiology, 1979A simplified in-vivo bioassay system was used to test the carcinogenic potential of halothane in Swiss/ICR mice. Halothane was tested only at its maximum tolerated dose, and histologic examination was performed only on tumor masses and other grossly abnormal tissues found at necropsy.
J M, Baden +4 more
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Effects of thiabendazole on the kidneys of ICR mice
Food and Chemical Toxicology, 1989The effects of thiabendazole (TBZ) on the kidneys of male and female Crj:CD-1 (ICR) mice were investigated. The mice were given 0, 250 or 500 mg TBZ/kg body weight/day by gavage (using olive oil as a vehicle) for 1, 3, 5 or 7 days. The 24-hr urine volumes of treated mice were increased, significantly so in male mice given the high dose of TBZ.
Y, Tada +4 more
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Patulin mycotoxicosis in Swiss ICR mice
Food and Cosmetics Toxicology, 1980Abstract Patulin is a toxic metabolite of several species of the genera Aspergillus and Penicillium. When administered to 10–15-g Swiss ICR mice by the oral, sc and ip routes, the 72-hr LD50 values were: oral 48·0, sc 10·0 and ip 7·5 mg/kg body weight.
E R, McKinley, W W, Carlton
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Reproductive toxicity of brazilein in ICR mice
Chinese Journal of Natural Medicines, 2016Brazilein is an active small molecular compound extracted from Caesalpinia sappan L. with favorable pharmacological properties on immune system, cardiovascular system, and nervous system. C. sappan has been used as a traditional medicine in China for hundreds of years for various diseases.
Zhi-Yi, Yuan +11 more
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A teratogenicity study of Phloxine B in ICR mice
Food and Chemical Toxicology, 1984Pregnant Jcl:ICR mice were given Phloxine B in the diet at concentrations of 0, 1, 3 and 5% from the morning of day 6 through day 16 of gestation. The mice were killed on day 18 and foetuses were examined for external, visceral and skeletal anomalies. A significant decrease in body-weight gain was observed in all of the treated groups.
M, Seno, S, Fukuda, H, Umisa
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Studies of the teratogenicity of xanthomegnin and viridicatumtoxin in ICR mice
Toxicology Letters, 1991The myotoxins xanthomegnin and viridicatumtoxin were not teratogenic when administered orally to pregnant ICR mice during the 8-12th and 8-13th days of gestation, respectively. Viridicatumtoxin produced high mortality in mice given 200, 250 or 350 mg/kg of body weight.
D C, Bolin +3 more
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