Results 11 to 20 of about 571,282 (185)

Method for the Intraoperative Detection of IDH Mutation in Gliomas with Differential Mobility Spectrometry. [PDF]

Curr Oncol, 2022
Isocitrate dehydrogenase (IDH) mutation status is an important factor for surgical decision-making: patients with IDH-mutated tumors are more likely to have a good long-term prognosis, and thus favor aggressive resection with more survival benefit to ...
Haapala I, Kondratev A, Roine A, Mäkelä M, Kontunen A, Karjalainen M, Laakso A, Koroknay-Pál P, Nordfors K, Haapasalo H, Oksala N, Vehkaoja A, Haapasalo J.   +12 more
europepmc   +5 more sources

Detection of IDH mutation in glioma by desorption electrospray ionization (DESI) tandem mass spectrometry. [PDF]

Sci Rep
Desorption electrospray ionization (DESI) tandem mass spectrometry (MS) is used to assess mutation status of isocitrate dehydrogenase (IDH) in human gliomas.
Shahi M, Pringle S, Morris M, Garcia DM, Quiñones-Hinojosa A, Cooks RG.   +5 more
europepmc   +3 more sources

Preoperative MRI enhancement grade for adult diffuse glioma affects IDH mutation and WHO grade

陆军军医大学学报
Objective To analyze the clinical features and magnetic resonance imaging (MRI) features of adult diffuse glioma, define the preoperative MRI enhancement grade (ET grade) of the disease, and explore the relationship of ET grade with isocitrate ...
CAO Yujuan, YAO Xiaohong
core   +2 more sources

idh-1 neomorphic mutation confers sensitivity to vitamin B12 in Caenorhabditis elegans

Life Science Alliance
In humans, a neomorphic isocitrate dehydrogenase mutation (idh-1neo) causes increased levels of cellular D-2-hydroxyglutarate (D-2HG), a proposed oncometabolite.
Ponomarova, Olga, Sundaram, Meera V, Belfi, Alexandra, Starbard, Alyxandra N, Anderson, Amanda V, Walhout, Albertha Jm   +5 more
core   +2 more sources

IDH mutation prediction in non-enhancing gliomas with relaxed T2-FLAIR mismatch and fractal dimension: a two-center study. [PDF]

BMC Med Imaging
Background To explore the relationship between relaxed T2-FLAIR mismatch (RT2FM) sign, fractal dimension (FD) of tumor contour and IDH mutation status, and construct models for IDH mutation prediction in non-enhancing gliomas.
Han Y, Zhang J, Xi YB, Xiu SJ, Yang Y, Wang YY.   +5 more
europepmc   +2 more sources

Comparison of MRI Sequences to Predict IDH Mutation Status in Gliomas Using Radiomics-Based Machine Learning

Biomedicines
Objectives: Regarding the 2021 World Health Organization (WHO) classification of central nervous system (CNS) tumors, the isocitrate dehydrogenase (IDH) mutation status is one of the most important factors for CNS tumor classification.
Manoj Mannil, Dilek N. G. Kasap, Nabila Gala Nacul Mora, Burak Han Akkurt, David A. Blömer, Manfred Musigmann, Walter Leonhard Heindel   +6 more
core   +2 more sources

Landscape of IDH1/2 mutations in Chinese patients with solid tumors: A pan‐cancer analysis

Molecular Genetics & Genomic Medicine, 2021
Background Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. However, the landscape of IDH mutations in pan‐cancer has not been fully characterized.
Dong Shen, Junling Zhang, Kai Yuan, Jing Zhao, Zhengyi Zhao, Longgang Cui, Yuzi Zhang, Guoqiang Wang, Shangli Cai, Yuezong Bai, Wei Li, Xiang Huang   +11 more
doaj   +1 more source

TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma

Frontiers in Cell and Developmental Biology, 2021
Mutation of the telomerase reverse transcriptase (TERT) promoter has been demonstrated as an unfavorable prognostic marker in patients with isocitrate dehydrogenase wild-type (IDHwt) glioma.
Mengqi Gao, Yi Lin, Xing Liu, Zheng Zhao, Zheng Zhao, Zhiyuan Zhu, Zhiyuan Zhu, Hongbo Zhang, Yunchao Ban, Yanan Bie, Xiaozheng He, Xiang Sun, Shizhong Zhang   +12 more
doaj   +1 more source

Value of contrast-enhanced CT texture analysis in predicting IDH mutation status of intrahepatic cholangiocarcinoma

Scientific Reports, 2021
To explore the value of contrast-enhanced CT texture analysis in predicting isocitrate dehydrogenase (IDH) mutation status of intrahepatic cholangiocarcinomas (ICCs). Institutional review board approved this study.
Yong Zhu, Yingfan Mao, Jun Chen, Yudong Qiu, Yue Guan, Zhongqiu Wang, Jian He   +6 more
doaj   +1 more source

Contralesional Structural Plasticity in Different Molecular Pathologic Subtypes of Insular Glioma

Frontiers in Neurology, 2021
Neuroplasticity may preserve neurologic function in insular glioma, thereby improving prognosis following resection. However, the anatomic and molecular bases of this phenomenon are not known.
Zhenxing Huang, Zhenxing Huang, Gen Li, Gen Li, Zhenye Li, Zhenye Li, Shengjun Sun, Shengjun Sun, Yazhuo Zhang, Yazhuo Zhang, Zonggang Hou, Zonggang Hou, Jian Xie, Jian Xie   +13 more
doaj   +1 more source