Results 21 to 30 of about 571,282 (185)

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Is the IDH Mutation a Good Target for Chondrosarcoma Treatment? [PDF]

, 2020
Chondrosarcomas are rare cancers of bone that arise from the malignant transformation of cells of chondrocytic lineage. They are known to be resistant to systemic cytotoxic chemotherapy and radiotherapy. The mainstay of management of localised disease is
Engelman, B, Wilding, C, Cojocaru, E, Huang, P, Jones, RL   +4 more
core   +1 more source

Characteristics of the isocitrate dehydrogenase gene and telomerase reverse transcriptase promoter mutations in gliomas in Chinese patients

Brain and Behavior, 2020
Objectives To explore the characteristics of IDH and TERT promoter mutations in gliomas in Chinese patients. Methods A total of 124 Chinese patients with gliomas were enrolled to study the frequencies of mutations in isocitrate dehydrogenase (IDH) and ...
Chong‐Xiao Qu, Hong‐Ming Ji, Xiang‐Cheng Shi, Hong Bi, Li‐Qin Zhai, De‐Wu Han   +5 more
doaj   +1 more source

Mutation testing on an object-oriented framework: An experience report [PDF]

, 2011
This is the preprint version of the article - Copyright @ 2011 ElsevierContext The increasing presence of Object-Oriented (OO) programs in industrial systems is progressively drawing the attention of mutation researchers toward this paradigm.
Sergio Segura, Segura, S, Benavides, D, Antonio Ruiz-Cortés, Ruiz Cortés, Antonio, Segura Rueda, Sergio, Robert M. Hierons, Benavides Cuevas, David Felipe, Hierons, Robert M., David Benavides, Hierons, RM, Ruiz-Cortes, A   +11 more
core   +1 more source

Deep learning can differentiate idh-mutant from idh-wild gbm [PDF]

, 2021
Isocitrate dehydrogenase (IDH) mutant and wildtype glioblastoma multiforme (GBM) often show overlapping features on magnetic resonance imaging (MRI), representing a diagnostic challenge.
Dellepiane F., Stoppacciaro A., Napolitano A., Romano A., Ranazzi G., Bozzao A., Tagliente E., Vidiri A., Pasquini L., Nicolai M., Moltoni G., Lucignani M., Di Napoli A.   +12 more
core   +2 more sources

O6-methylguanine-DNA methyltransferase promoter methylation and isocitrate dehydrogenase mutation as prognostic factors in a cohort of Saudi patients with glioblastoma

Annals of Saudi Medicine, 2019
BACKGROUND: Treatment of glioblastoma (GB), the most common malignant primary brain tumor in adults, can include alkylating chemo-therapeutic agents.
Ali H. Alassiri, Ali Alkhaibary, Saud Al-Sarheed, Fahd Alsufani, Mohammed Alharbi, Ahmed Alkhani, Ahmed Aloraidi   +6 more
doaj   +1 more source

Hub gene identification and prognostic model construction for isocitrate dehydrogenase mutation in glioma

Translational Oncology, 2021
Our study attempted to identify hub genes related to isocitrate dehydrogenase (IDH) mutation in glioma and develop a prognostic model for IDH-mutant glioma patients.
Yanfei Jia, Wenzhen Yang, Bo Tang, Qian Feng, Zhiqiang Dong   +4 more
doaj   +1 more source

Comprehensive Metabolomic Analysis of IDH1 R132H Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency

Scientific Reports, 2019
Gliomas with Isocitrate dehydrogenase 1 (IDH1) mutation have alterations in several enzyme activities, resulting in various metabolic changes. The aim of this study was to determine a mechanism for the better prognosis of gliomas with IDH mutation by ...
Satsuki Miyata, Kaoru Tominaga, Eiji Sakashita, Masashi Urabe, Yoshiyuki Onuki, Akira Gomi, Takashi Yamaguchi, Makiko Mieno, Hiroaki Mizukami, Akihiro Kume, Keiya Ozawa, Eiju Watanabe, Kensuke Kawai, Hitoshi Endo   +13 more
doaj   +1 more source

The prognostic role of IDH mutations in homogeneously treated patients with anaplastic astrocytomas and glioblastomas

Acta Neuropathologica Communications, 2019
The detection of IDH mutations in patients with diffusely infiltrating malignant astrocytomas resulted in substantial modifications in the concept of WHO classification of these tumors.
Arne Christians, Antonia Adel-Horowski, Rouzbeh Banan, Ulrich Lehmann, Stephan Bartels, Felix Behling, Alonso Barrantes-Freer, Christine Stadelmann, Veit Rohde, Florian Stockhammer, Christian Hartmann   +10 more
doaj   +1 more source

Impact of CDKN2A/B Homozygous Deletion on the Prognosis and Biology of IDH-Mutant Glioma

Biomedicines, 2022
Although hotspot mutations in isocitrate dehydrogenase (IDH) genes are associated with favorable clinical outcomes in glioma, CDKN2A/B homozygous deletion has been identified as an independent predicator of poor prognosis.
L. Eric Huang
doaj   +1 more source